Aggressiveness of solid pseudopapillary neoplasm of the pancreas

Emmanuel Ii Uy Hao, Ho Kyung Hwang, Dong Sub Yoon, Woo Jung Lee, Chang Moo Kang

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

Background: Solid pseudopapillary neoplasms (SPNs) of the pancreas are rare tumors considered to be benign although 10% to 15% of SPNs have been reported to be aggressive. Due to its rarity, there have only been a few cases reported regarding the clinical course of patients with aggressive SPNs. The goal of this study is to describe the clinical course of patients diagnosed with aggressive SPNs. Methods: A PubMed search was done looking for articles describing the clinical course of patients diagnosed with SPN that locally invaded, recurred, or metastasized. Institutional experience was also added to the pooled data. Patient information was extracted from the articles. Survival and recurrence curves were plotted and factors associated with survival and recurrences were analyzed. Results: A total of 59 patients were identified to have aggressive SPN. Seven patients were males and 52 were females and the mean age was 37.44±2.21 years. Systemic metastasis constituted 81.4% while recurrence and deep tissue invasion were found in 11.9% and 6.8% of the patients, respectively. Disease-free survival was 45±6.28 months and disease-specific survival was 152.67 ±12.8 months. In survival analysis, age, gender, tumor size, tumor location, combined resection, type of recurrence, and stage IV on diagnosis were not significant factors in predicting survival. However, an unresectable tumor (hazards ratio [HR]=4.871, 95% confidence interval [CI] 1.480-16.03, P=.009), and metastasis within 36 months (HR=6.399, 95% CI: 1.390-29.452, P=.017) were identified as independent variables in predicting survival. Conclusion: SPNs of the pancreas carry a favorable course. Despite having aggressive properties, patients can still survive for more than 10 years as long as the tumor can be resected completely.

Original languageEnglish
Article numbere13147
JournalMedicine (United States)
Volume97
Issue number49
DOIs
Publication statusPublished - 2018 Dec 1

Fingerprint

Pancreatic Neoplasms
Neoplasms
Survival
Recurrence
Confidence Intervals
Neoplasm Metastasis
Survival Analysis
PubMed
Disease-Free Survival

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Hao, Emmanuel Ii Uy ; Hwang, Ho Kyung ; Yoon, Dong Sub ; Lee, Woo Jung ; Kang, Chang Moo. / Aggressiveness of solid pseudopapillary neoplasm of the pancreas. In: Medicine (United States). 2018 ; Vol. 97, No. 49.
@article{fe6ce4f25d1148539b85ffbf4d1cb44e,
title = "Aggressiveness of solid pseudopapillary neoplasm of the pancreas",
abstract = "Background: Solid pseudopapillary neoplasms (SPNs) of the pancreas are rare tumors considered to be benign although 10{\%} to 15{\%} of SPNs have been reported to be aggressive. Due to its rarity, there have only been a few cases reported regarding the clinical course of patients with aggressive SPNs. The goal of this study is to describe the clinical course of patients diagnosed with aggressive SPNs. Methods: A PubMed search was done looking for articles describing the clinical course of patients diagnosed with SPN that locally invaded, recurred, or metastasized. Institutional experience was also added to the pooled data. Patient information was extracted from the articles. Survival and recurrence curves were plotted and factors associated with survival and recurrences were analyzed. Results: A total of 59 patients were identified to have aggressive SPN. Seven patients were males and 52 were females and the mean age was 37.44±2.21 years. Systemic metastasis constituted 81.4{\%} while recurrence and deep tissue invasion were found in 11.9{\%} and 6.8{\%} of the patients, respectively. Disease-free survival was 45±6.28 months and disease-specific survival was 152.67 ±12.8 months. In survival analysis, age, gender, tumor size, tumor location, combined resection, type of recurrence, and stage IV on diagnosis were not significant factors in predicting survival. However, an unresectable tumor (hazards ratio [HR]=4.871, 95{\%} confidence interval [CI] 1.480-16.03, P=.009), and metastasis within 36 months (HR=6.399, 95{\%} CI: 1.390-29.452, P=.017) were identified as independent variables in predicting survival. Conclusion: SPNs of the pancreas carry a favorable course. Despite having aggressive properties, patients can still survive for more than 10 years as long as the tumor can be resected completely.",
author = "Hao, {Emmanuel Ii Uy} and Hwang, {Ho Kyung} and Yoon, {Dong Sub} and Lee, {Woo Jung} and Kang, {Chang Moo}",
year = "2018",
month = "12",
day = "1",
doi = "10.1097/MD.0000000000013147",
language = "English",
volume = "97",
journal = "Medicine (United States)",
issn = "0025-7974",
publisher = "Lippincott Williams and Wilkins",
number = "49",

}

Aggressiveness of solid pseudopapillary neoplasm of the pancreas. / Hao, Emmanuel Ii Uy; Hwang, Ho Kyung; Yoon, Dong Sub; Lee, Woo Jung; Kang, Chang Moo.

In: Medicine (United States), Vol. 97, No. 49, e13147, 01.12.2018.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Aggressiveness of solid pseudopapillary neoplasm of the pancreas

AU - Hao, Emmanuel Ii Uy

AU - Hwang, Ho Kyung

AU - Yoon, Dong Sub

AU - Lee, Woo Jung

AU - Kang, Chang Moo

PY - 2018/12/1

Y1 - 2018/12/1

N2 - Background: Solid pseudopapillary neoplasms (SPNs) of the pancreas are rare tumors considered to be benign although 10% to 15% of SPNs have been reported to be aggressive. Due to its rarity, there have only been a few cases reported regarding the clinical course of patients with aggressive SPNs. The goal of this study is to describe the clinical course of patients diagnosed with aggressive SPNs. Methods: A PubMed search was done looking for articles describing the clinical course of patients diagnosed with SPN that locally invaded, recurred, or metastasized. Institutional experience was also added to the pooled data. Patient information was extracted from the articles. Survival and recurrence curves were plotted and factors associated with survival and recurrences were analyzed. Results: A total of 59 patients were identified to have aggressive SPN. Seven patients were males and 52 were females and the mean age was 37.44±2.21 years. Systemic metastasis constituted 81.4% while recurrence and deep tissue invasion were found in 11.9% and 6.8% of the patients, respectively. Disease-free survival was 45±6.28 months and disease-specific survival was 152.67 ±12.8 months. In survival analysis, age, gender, tumor size, tumor location, combined resection, type of recurrence, and stage IV on diagnosis were not significant factors in predicting survival. However, an unresectable tumor (hazards ratio [HR]=4.871, 95% confidence interval [CI] 1.480-16.03, P=.009), and metastasis within 36 months (HR=6.399, 95% CI: 1.390-29.452, P=.017) were identified as independent variables in predicting survival. Conclusion: SPNs of the pancreas carry a favorable course. Despite having aggressive properties, patients can still survive for more than 10 years as long as the tumor can be resected completely.

AB - Background: Solid pseudopapillary neoplasms (SPNs) of the pancreas are rare tumors considered to be benign although 10% to 15% of SPNs have been reported to be aggressive. Due to its rarity, there have only been a few cases reported regarding the clinical course of patients with aggressive SPNs. The goal of this study is to describe the clinical course of patients diagnosed with aggressive SPNs. Methods: A PubMed search was done looking for articles describing the clinical course of patients diagnosed with SPN that locally invaded, recurred, or metastasized. Institutional experience was also added to the pooled data. Patient information was extracted from the articles. Survival and recurrence curves were plotted and factors associated with survival and recurrences were analyzed. Results: A total of 59 patients were identified to have aggressive SPN. Seven patients were males and 52 were females and the mean age was 37.44±2.21 years. Systemic metastasis constituted 81.4% while recurrence and deep tissue invasion were found in 11.9% and 6.8% of the patients, respectively. Disease-free survival was 45±6.28 months and disease-specific survival was 152.67 ±12.8 months. In survival analysis, age, gender, tumor size, tumor location, combined resection, type of recurrence, and stage IV on diagnosis were not significant factors in predicting survival. However, an unresectable tumor (hazards ratio [HR]=4.871, 95% confidence interval [CI] 1.480-16.03, P=.009), and metastasis within 36 months (HR=6.399, 95% CI: 1.390-29.452, P=.017) were identified as independent variables in predicting survival. Conclusion: SPNs of the pancreas carry a favorable course. Despite having aggressive properties, patients can still survive for more than 10 years as long as the tumor can be resected completely.

UR - http://www.scopus.com/inward/record.url?scp=85058742078&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85058742078&partnerID=8YFLogxK

U2 - 10.1097/MD.0000000000013147

DO - 10.1097/MD.0000000000013147

M3 - Review article

C2 - 30544374

AN - SCOPUS:85058742078

VL - 97

JO - Medicine (United States)

JF - Medicine (United States)

SN - 0025-7974

IS - 49

M1 - e13147

ER -