Agmatine attenuates brain edema and apoptotic cell death after traumatic brain injury

Jae Young Kim, Yong Woo Lee, Jae Hwan Kim, Won Taek Lee, Kyung Ah Park, Jong Eun Lee

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Traumatic brain injury (TBI) is associated with poor neurological outcome, including necrosis and brain edema. In this study, we investigated whether agmatine treatment reduces edema and apoptotic cell death after TBI. TBI was produced by cold injury to the cerebral primary motor cortex of rats. Agmatine was administered 30 min after injury and once daily until the end of the experiment. Animals were sacrificed for analysis at 1, 2, or 7 days after the injury. Various neurological analyses were performed to investigate disruption of the blood-brain barrier (BBB) and neurological dysfunction after TBI. To examine the extent of brain edema after TBI, the expression of aquaporins (AQPs), phosphorylation of mitogen-activated protein kinases (MAPKs), and nuclear translocation of nuclear factor-κB (NF-κB) were investigated. Our findings demonstrated that agmatine treatment significantly reduces brain edema after TBI by suppressing the expression of AQP1, 4, and 9. In addition, agmatine treatment significantly reduced apoptotic cell death by suppressing the phosphorylation of MAPKs and by increasing the nuclear translocation of NF-κB after TBI. These results suggest that agmatine treatment may have therapeutic potential for brain edema and neural cell death in various central nervous system diseases.

Original languageEnglish
Pages (from-to)943-952
Number of pages10
JournalJournal of Korean medical science
Volume30
Issue number7
DOIs
Publication statusPublished - 2015 Jan 1

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Agmatine
Brain Edema
Cell Death
Mitogen-Activated Protein Kinases
Phosphorylation
Aquaporins
Central Nervous System Diseases
Wounds and Injuries
Motor Cortex
Traumatic Brain Injury
Blood-Brain Barrier
Edema
Necrosis

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Kim, Jae Young ; Lee, Yong Woo ; Kim, Jae Hwan ; Lee, Won Taek ; Park, Kyung Ah ; Lee, Jong Eun. / Agmatine attenuates brain edema and apoptotic cell death after traumatic brain injury. In: Journal of Korean medical science. 2015 ; Vol. 30, No. 7. pp. 943-952.
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Agmatine attenuates brain edema and apoptotic cell death after traumatic brain injury. / Kim, Jae Young; Lee, Yong Woo; Kim, Jae Hwan; Lee, Won Taek; Park, Kyung Ah; Lee, Jong Eun.

In: Journal of Korean medical science, Vol. 30, No. 7, 01.01.2015, p. 943-952.

Research output: Contribution to journalArticle

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