Agmatine reduces nitric oxide synthase expression and peroxynitrite formation in the cerebral cortex in a rat model of transient global cerebral ischemia

Chin Hee Mun, Won Taek Lee, Kyung Ah Park, Jongeun Lee

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Agmatine, an analog of L-arginine, is an endogenous substance synthesized by arginine decarboxylase, which has been shown to possess neuroprotective effects following brain ischemia. Nitric oxide is generated by sequential oxidation of the guanidinium group in L-arginine, and agmatine might protect the brain from ischemic injury by interfering with nitric oxide signaling. This study investigated the effects of agmatine on cerebral cortex neuronal injury following transient global cerebral ischemia and also detected nitric oxide synthase expression and peroxynitrite formation. Results demonstrated that intraperitoneal injection of agmatine in global cerebral ischemia/reperfusion alleviated ischemia/reperfusion-induced cerebral cortical cortex neuronal injury and cellular apoptosis, decreased neuronal and inducible nitric oxide synthase expression at 24, 48, and 72 hours following global cerebral ischemia and reperfusion, and greatly inhibited nitrotyrosine levels, which reflect the amount of peroxynitrite formed. These findings indicated that agmatine alleviates cerebral cortex neuronal injury following global cerebral ischemia and decreases nitric oxide synthase expression and peroxynitrite formation following ischemia/reperfusion.

Original languageEnglish
Pages (from-to)1773-1781
Number of pages9
JournalNeural Regeneration Research
Volume5
Issue number23
Publication statusPublished - 2010 Dec 1

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Agmatine
Peroxynitrous Acid
Transient Ischemic Attack
Nitric Oxide Synthase
Cerebral Cortex
Brain Ischemia
Reperfusion
Arginine
Wounds and Injuries
Nitric Oxide
Ischemia
Nitric Oxide Synthase Type I
Guanidine
Neuroprotective Agents
Nitric Oxide Synthase Type II
Intraperitoneal Injections
Brain Injuries
Apoptosis

All Science Journal Classification (ASJC) codes

  • Developmental Neuroscience

Cite this

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abstract = "Agmatine, an analog of L-arginine, is an endogenous substance synthesized by arginine decarboxylase, which has been shown to possess neuroprotective effects following brain ischemia. Nitric oxide is generated by sequential oxidation of the guanidinium group in L-arginine, and agmatine might protect the brain from ischemic injury by interfering with nitric oxide signaling. This study investigated the effects of agmatine on cerebral cortex neuronal injury following transient global cerebral ischemia and also detected nitric oxide synthase expression and peroxynitrite formation. Results demonstrated that intraperitoneal injection of agmatine in global cerebral ischemia/reperfusion alleviated ischemia/reperfusion-induced cerebral cortical cortex neuronal injury and cellular apoptosis, decreased neuronal and inducible nitric oxide synthase expression at 24, 48, and 72 hours following global cerebral ischemia and reperfusion, and greatly inhibited nitrotyrosine levels, which reflect the amount of peroxynitrite formed. These findings indicated that agmatine alleviates cerebral cortex neuronal injury following global cerebral ischemia and decreases nitric oxide synthase expression and peroxynitrite formation following ischemia/reperfusion.",
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Agmatine reduces nitric oxide synthase expression and peroxynitrite formation in the cerebral cortex in a rat model of transient global cerebral ischemia. / Mun, Chin Hee; Lee, Won Taek; Park, Kyung Ah; Lee, Jongeun.

In: Neural Regeneration Research, Vol. 5, No. 23, 01.12.2010, p. 1773-1781.

Research output: Contribution to journalArticle

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AU - Lee, Won Taek

AU - Park, Kyung Ah

AU - Lee, Jongeun

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