Air atmospheric pressure plasma jet pretreatment for drop-wise loading of dexamethasone on hydroxyapatite scaffold for increase of osteoblast attachment

Jung Hwan Lee, Jae Sung Kwon, Yong Hee Kim, Eun Ha Choi, Kwangmahn Kim, Kyoung Nam Kim

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Periodontal disease affects alveolar bone resorption around the involved teeth. To gain bone height, bone graft materials have been widely used with drug carriers. Application of an atmospheric pressure plasma jet (APPJ) treatment is widely studied due to its ability to change surface characteristics without topographical change. The aim of this study is to identify whether the air APPJ (AAPPJ) treatment before drop-wise loading performance could change loaded amount of dexamethasone, and induce increase of cell attachment and proliferation. The results suggested that AAPPJ treatment decreased the contact angle down to about 13°, which increased gradually but significantly lowered at least 4 days compared to no-treated group. After AAPPJ treatment, hydrocarbon was removed with change of zeta potential into positive charge. However, the AAPPJ treatment did not change the quantity or releasing profile of dexamethasone (p > 0.05). Confocal analysis combined with DNA proliferation analysis showed increase of osteoblast attachment and proliferation. Hence, AAPPJ could be a useful pretreatment method before drop-wise loading on HA scaffold with dexamethasone for increase of osteoblast attachment.

Original languageEnglish
Pages (from-to)7654-7661
Number of pages8
JournalJournal of Nanoscience and Nanotechnology
Volume14
Issue number10
DOIs
Publication statusPublished - 2014 Oct 1

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Air Pressure
osteoblasts
Plasma jets
Atmospheric Pressure
Osteoblasts
Durapatite
Hydroxyapatite
Scaffolds
pretreatment
plasma jets
Dexamethasone
Atmospheric pressure
attachment
atmospheric pressure
Air
air
bones
Bone
Alveolar Bone Loss
Therapeutics

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

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title = "Air atmospheric pressure plasma jet pretreatment for drop-wise loading of dexamethasone on hydroxyapatite scaffold for increase of osteoblast attachment",
abstract = "Periodontal disease affects alveolar bone resorption around the involved teeth. To gain bone height, bone graft materials have been widely used with drug carriers. Application of an atmospheric pressure plasma jet (APPJ) treatment is widely studied due to its ability to change surface characteristics without topographical change. The aim of this study is to identify whether the air APPJ (AAPPJ) treatment before drop-wise loading performance could change loaded amount of dexamethasone, and induce increase of cell attachment and proliferation. The results suggested that AAPPJ treatment decreased the contact angle down to about 13°, which increased gradually but significantly lowered at least 4 days compared to no-treated group. After AAPPJ treatment, hydrocarbon was removed with change of zeta potential into positive charge. However, the AAPPJ treatment did not change the quantity or releasing profile of dexamethasone (p > 0.05). Confocal analysis combined with DNA proliferation analysis showed increase of osteoblast attachment and proliferation. Hence, AAPPJ could be a useful pretreatment method before drop-wise loading on HA scaffold with dexamethasone for increase of osteoblast attachment.",
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Air atmospheric pressure plasma jet pretreatment for drop-wise loading of dexamethasone on hydroxyapatite scaffold for increase of osteoblast attachment. / Lee, Jung Hwan; Kwon, Jae Sung; Kim, Yong Hee; Choi, Eun Ha; Kim, Kwangmahn; Kim, Kyoung Nam.

In: Journal of Nanoscience and Nanotechnology, Vol. 14, No. 10, 01.10.2014, p. 7654-7661.

Research output: Contribution to journalArticle

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AU - Lee, Jung Hwan

AU - Kwon, Jae Sung

AU - Kim, Yong Hee

AU - Choi, Eun Ha

AU - Kim, Kwangmahn

AU - Kim, Kyoung Nam

PY - 2014/10/1

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