Airway hyperresponsiveness is negatively associated with obesity or overweight status in patients with asthma

Jae Woo Kwon, Sae Hoon Kim, Tae Bum Kim, Sang Heon Kim, Heung Woo Park, Yoon Seok Chang, An Soo Jang, You Sook Cho, Dong Ho Nahm, Jung Won Park, Ho Joo Yoon, Young Joo Cho, Byoung Whui Choi, Hee Bom Moon, Sang Heon Cho

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19 Citations (Scopus)

Abstract

Background: Obesity is a risk factor for asthma in the general population, but the effect of obesity on airway hyperresponsiveness (AFHR) or airway inflammation in asthma is not clear. This study evaluated the relationship between obesity and asthma, assessing aspects of symptoms, AHR, and severity. Methods: In total, 852 patients with asthma diagnosed by asthma specialists based on AHR as confirmed by a methacholine bronchial provocation test, were enrolled from the Cohort for Reality and Evolution of Adult Asthma in Korea (COREA) adult asthma cohort. The intensity of AHR was assessed by the concentration of methacholine needed to cause a 20% decrease in FEV1 (PC20). Patients were classified into four categories based on body mass index (BMI): underweight (<18.5), normal weight (18.5-24.9), overweight (25.0-29.9), and obese (≥30). Results: BMI was negatively correlated with FEV1 (l), FVC (l), and FEV1/FVC (%) in lung function tests. The prevalence of wheezing increased with higher BMI after adjustment for age, sex, smoking, medication history, and PC20 (p < 0.0001). logPC20 was lower in the normal weight group compared with the overweight group (p = 0.003). The risk of moderate or severe AHR (PC 20 ≤ 4 mg/ml) decreased with increased BMI after adjustment for age, sex, smoking, and medication history (p = 0.035). Conclusions: Obesity is a risk factor for asthma in the general population, but obesity in asthmatic patients is negatively correlated with the intensity of AHR and is not related to asthma severity. Obesity is positively related with the prevalence of wheezing but negatively related to AHR in asthmatic patients.

Original languageEnglish
Pages (from-to)187-193
Number of pages7
JournalInternational Archives of Allergy and Immunology
Volume159
Issue number2
DOIs
Publication statusPublished - 2012 Sep 1

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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    Kwon, J. W., Kim, S. H., Kim, T. B., Kim, S. H., Park, H. W., Chang, Y. S., Jang, A. S., Cho, Y. S., Nahm, D. H., Park, J. W., Yoon, H. J., Cho, Y. J., Choi, B. W., Moon, H. B., & Cho, S. H. (2012). Airway hyperresponsiveness is negatively associated with obesity or overweight status in patients with asthma. International Archives of Allergy and Immunology, 159(2), 187-193. https://doi.org/10.1159/000335926