Albuminuria, Cerebrovascular Disease and Cortical Atrophy: Among Cognitively Normal Elderly Individuals

Eun Bin Cho, Hee Young Shin, Sang Eon Park, Phillip Chun, Hye Ryoun Jang, Jin Ju Yang, Hee Jin Kim, Yeo Jin Kim, Na Yeon Jung, Jin San Lee, Juyoun Lee, Young Kyoung Jang, Eun Young Jang, Mira Kang, Jong Min Lee, Changsoo Kim, Ju Hong Min, Seungho Ryu, Duk L. Na, Sang Won Seo

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

We tested the hypothesis that decreased glomerular filtration rate and albuminuria have different roles in brain structure alterations. We enrolled 1,215 cognitively normal individuals, all of whom underwent high-resolution T1-weighted volumetric magnetic resonance imaging scans. The cerebral small vessel disease burdens were assessed with white matter hyperintensities (WMH), lacunes, and microbleeds. Subjects were considered to have an abnormally elevated urine albumin creatinine ratio if the value was ≥17 mg/g for men and ≥25 mg/g for women. Albuminuria, but not estimated glomerular filtration rate (eGFR), was associated with increased WMH burdens (p = 0.002). The data was analyzed after adjusting for age, sex, education, history of hypertension, diabetes mellitus, hyperlipidemia, ischemic heart disease, stroke, total cholesterol level, body mass index, status of smoking and alcohol drinking, and intracranial volume. Albuminuria was also associated with cortical thinning, predominantly in the frontal and occipital regions (both p < 0.01) in multiple linear regression analysis. However, eGFR was not associated with cortical thickness. Furthermore, path analysis for cortical thickness showed that albuminuria was associated with frontal thinning partially mediated by WMH burdens. The assessment of albuminuria is needed to improve our ability to identify individuals with high risk for cognitive impairments, and further institute appropriate preventive measures.

Original languageEnglish
Article number20692
JournalScientific reports
Volume6
DOIs
Publication statusPublished - 2016 Feb 15

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Cerebrovascular Disorders
Albuminuria
Atrophy
Glomerular Filtration Rate
Cerebral Small Vessel Diseases
Occipital Lobe
Aptitude
Sex Education
Hyperlipidemias
Alcohol Drinking
Myocardial Ischemia
Albumins
Linear Models
Creatinine
Diabetes Mellitus
Body Mass Index
Smoking
Stroke
Cholesterol
Regression Analysis

All Science Journal Classification (ASJC) codes

  • General

Cite this

Cho, E. B., Shin, H. Y., Park, S. E., Chun, P., Jang, H. R., Yang, J. J., ... Seo, S. W. (2016). Albuminuria, Cerebrovascular Disease and Cortical Atrophy: Among Cognitively Normal Elderly Individuals. Scientific reports, 6, [20692]. https://doi.org/10.1038/srep20692
Cho, Eun Bin ; Shin, Hee Young ; Park, Sang Eon ; Chun, Phillip ; Jang, Hye Ryoun ; Yang, Jin Ju ; Kim, Hee Jin ; Kim, Yeo Jin ; Jung, Na Yeon ; Lee, Jin San ; Lee, Juyoun ; Jang, Young Kyoung ; Jang, Eun Young ; Kang, Mira ; Lee, Jong Min ; Kim, Changsoo ; Min, Ju Hong ; Ryu, Seungho ; Na, Duk L. ; Seo, Sang Won. / Albuminuria, Cerebrovascular Disease and Cortical Atrophy : Among Cognitively Normal Elderly Individuals. In: Scientific reports. 2016 ; Vol. 6.
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abstract = "We tested the hypothesis that decreased glomerular filtration rate and albuminuria have different roles in brain structure alterations. We enrolled 1,215 cognitively normal individuals, all of whom underwent high-resolution T1-weighted volumetric magnetic resonance imaging scans. The cerebral small vessel disease burdens were assessed with white matter hyperintensities (WMH), lacunes, and microbleeds. Subjects were considered to have an abnormally elevated urine albumin creatinine ratio if the value was ≥17 mg/g for men and ≥25 mg/g for women. Albuminuria, but not estimated glomerular filtration rate (eGFR), was associated with increased WMH burdens (p = 0.002). The data was analyzed after adjusting for age, sex, education, history of hypertension, diabetes mellitus, hyperlipidemia, ischemic heart disease, stroke, total cholesterol level, body mass index, status of smoking and alcohol drinking, and intracranial volume. Albuminuria was also associated with cortical thinning, predominantly in the frontal and occipital regions (both p < 0.01) in multiple linear regression analysis. However, eGFR was not associated with cortical thickness. Furthermore, path analysis for cortical thickness showed that albuminuria was associated with frontal thinning partially mediated by WMH burdens. The assessment of albuminuria is needed to improve our ability to identify individuals with high risk for cognitive impairments, and further institute appropriate preventive measures.",
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Cho, EB, Shin, HY, Park, SE, Chun, P, Jang, HR, Yang, JJ, Kim, HJ, Kim, YJ, Jung, NY, Lee, JS, Lee, J, Jang, YK, Jang, EY, Kang, M, Lee, JM, Kim, C, Min, JH, Ryu, S, Na, DL & Seo, SW 2016, 'Albuminuria, Cerebrovascular Disease and Cortical Atrophy: Among Cognitively Normal Elderly Individuals', Scientific reports, vol. 6, 20692. https://doi.org/10.1038/srep20692

Albuminuria, Cerebrovascular Disease and Cortical Atrophy : Among Cognitively Normal Elderly Individuals. / Cho, Eun Bin; Shin, Hee Young; Park, Sang Eon; Chun, Phillip; Jang, Hye Ryoun; Yang, Jin Ju; Kim, Hee Jin; Kim, Yeo Jin; Jung, Na Yeon; Lee, Jin San; Lee, Juyoun; Jang, Young Kyoung; Jang, Eun Young; Kang, Mira; Lee, Jong Min; Kim, Changsoo; Min, Ju Hong; Ryu, Seungho; Na, Duk L.; Seo, Sang Won.

In: Scientific reports, Vol. 6, 20692, 15.02.2016.

Research output: Contribution to journalArticle

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AU - Cho, Eun Bin

AU - Shin, Hee Young

AU - Park, Sang Eon

AU - Chun, Phillip

AU - Jang, Hye Ryoun

AU - Yang, Jin Ju

AU - Kim, Hee Jin

AU - Kim, Yeo Jin

AU - Jung, Na Yeon

AU - Lee, Jin San

AU - Lee, Juyoun

AU - Jang, Young Kyoung

AU - Jang, Eun Young

AU - Kang, Mira

AU - Lee, Jong Min

AU - Kim, Changsoo

AU - Min, Ju Hong

AU - Ryu, Seungho

AU - Na, Duk L.

AU - Seo, Sang Won

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N2 - We tested the hypothesis that decreased glomerular filtration rate and albuminuria have different roles in brain structure alterations. We enrolled 1,215 cognitively normal individuals, all of whom underwent high-resolution T1-weighted volumetric magnetic resonance imaging scans. The cerebral small vessel disease burdens were assessed with white matter hyperintensities (WMH), lacunes, and microbleeds. Subjects were considered to have an abnormally elevated urine albumin creatinine ratio if the value was ≥17 mg/g for men and ≥25 mg/g for women. Albuminuria, but not estimated glomerular filtration rate (eGFR), was associated with increased WMH burdens (p = 0.002). The data was analyzed after adjusting for age, sex, education, history of hypertension, diabetes mellitus, hyperlipidemia, ischemic heart disease, stroke, total cholesterol level, body mass index, status of smoking and alcohol drinking, and intracranial volume. Albuminuria was also associated with cortical thinning, predominantly in the frontal and occipital regions (both p < 0.01) in multiple linear regression analysis. However, eGFR was not associated with cortical thickness. Furthermore, path analysis for cortical thickness showed that albuminuria was associated with frontal thinning partially mediated by WMH burdens. The assessment of albuminuria is needed to improve our ability to identify individuals with high risk for cognitive impairments, and further institute appropriate preventive measures.

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