Abstract
We tested the hypothesis that decreased glomerular filtration rate and albuminuria have different roles in brain structure alterations. We enrolled 1,215 cognitively normal individuals, all of whom underwent high-resolution T1-weighted volumetric magnetic resonance imaging scans. The cerebral small vessel disease burdens were assessed with white matter hyperintensities (WMH), lacunes, and microbleeds. Subjects were considered to have an abnormally elevated urine albumin creatinine ratio if the value was ≥17 mg/g for men and ≥25 mg/g for women. Albuminuria, but not estimated glomerular filtration rate (eGFR), was associated with increased WMH burdens (p = 0.002). The data was analyzed after adjusting for age, sex, education, history of hypertension, diabetes mellitus, hyperlipidemia, ischemic heart disease, stroke, total cholesterol level, body mass index, status of smoking and alcohol drinking, and intracranial volume. Albuminuria was also associated with cortical thinning, predominantly in the frontal and occipital regions (both p < 0.01) in multiple linear regression analysis. However, eGFR was not associated with cortical thickness. Furthermore, path analysis for cortical thickness showed that albuminuria was associated with frontal thinning partially mediated by WMH burdens. The assessment of albuminuria is needed to improve our ability to identify individuals with high risk for cognitive impairments, and further institute appropriate preventive measures.
| Original language | English |
|---|---|
| Article number | 20692 |
| Journal | Scientific reports |
| Volume | 6 |
| DOIs | |
| Publication status | Published - 2016 Feb 15 |
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Albuminuria, Cerebrovascular Disease and Cortical Atrophy : Among Cognitively Normal Elderly Individuals. / Cho, Eun Bin; Shin, Hee Young; Park, Sang Eon; Chun, Phillip; Jang, Hye Ryoun; Yang, Jin Ju; Kim, Hee Jin; Kim, Yeo Jin; Jung, Na Yeon; Lee, Jin San; Lee, Juyoun; Jang, Young Kyoung; Jang, Eun Young; Kang, Mira; Lee, Jong Min; Kim, Changsoo; Min, Ju Hong; Ryu, Seungho; Na, Duk L.; Seo, Sang Won.
In: Scientific reports, Vol. 6, 20692, 15.02.2016.Research output: Contribution to journal › Article
TY - JOUR
T1 - Albuminuria, Cerebrovascular Disease and Cortical Atrophy
T2 - Among Cognitively Normal Elderly Individuals
AU - Cho, Eun Bin
AU - Shin, Hee Young
AU - Park, Sang Eon
AU - Chun, Phillip
AU - Jang, Hye Ryoun
AU - Yang, Jin Ju
AU - Kim, Hee Jin
AU - Kim, Yeo Jin
AU - Jung, Na Yeon
AU - Lee, Jin San
AU - Lee, Juyoun
AU - Jang, Young Kyoung
AU - Jang, Eun Young
AU - Kang, Mira
AU - Lee, Jong Min
AU - Kim, Changsoo
AU - Min, Ju Hong
AU - Ryu, Seungho
AU - Na, Duk L.
AU - Seo, Sang Won
PY - 2016/2/15
Y1 - 2016/2/15
N2 - We tested the hypothesis that decreased glomerular filtration rate and albuminuria have different roles in brain structure alterations. We enrolled 1,215 cognitively normal individuals, all of whom underwent high-resolution T1-weighted volumetric magnetic resonance imaging scans. The cerebral small vessel disease burdens were assessed with white matter hyperintensities (WMH), lacunes, and microbleeds. Subjects were considered to have an abnormally elevated urine albumin creatinine ratio if the value was ≥17 mg/g for men and ≥25 mg/g for women. Albuminuria, but not estimated glomerular filtration rate (eGFR), was associated with increased WMH burdens (p = 0.002). The data was analyzed after adjusting for age, sex, education, history of hypertension, diabetes mellitus, hyperlipidemia, ischemic heart disease, stroke, total cholesterol level, body mass index, status of smoking and alcohol drinking, and intracranial volume. Albuminuria was also associated with cortical thinning, predominantly in the frontal and occipital regions (both p < 0.01) in multiple linear regression analysis. However, eGFR was not associated with cortical thickness. Furthermore, path analysis for cortical thickness showed that albuminuria was associated with frontal thinning partially mediated by WMH burdens. The assessment of albuminuria is needed to improve our ability to identify individuals with high risk for cognitive impairments, and further institute appropriate preventive measures.
AB - We tested the hypothesis that decreased glomerular filtration rate and albuminuria have different roles in brain structure alterations. We enrolled 1,215 cognitively normal individuals, all of whom underwent high-resolution T1-weighted volumetric magnetic resonance imaging scans. The cerebral small vessel disease burdens were assessed with white matter hyperintensities (WMH), lacunes, and microbleeds. Subjects were considered to have an abnormally elevated urine albumin creatinine ratio if the value was ≥17 mg/g for men and ≥25 mg/g for women. Albuminuria, but not estimated glomerular filtration rate (eGFR), was associated with increased WMH burdens (p = 0.002). The data was analyzed after adjusting for age, sex, education, history of hypertension, diabetes mellitus, hyperlipidemia, ischemic heart disease, stroke, total cholesterol level, body mass index, status of smoking and alcohol drinking, and intracranial volume. Albuminuria was also associated with cortical thinning, predominantly in the frontal and occipital regions (both p < 0.01) in multiple linear regression analysis. However, eGFR was not associated with cortical thickness. Furthermore, path analysis for cortical thickness showed that albuminuria was associated with frontal thinning partially mediated by WMH burdens. The assessment of albuminuria is needed to improve our ability to identify individuals with high risk for cognitive impairments, and further institute appropriate preventive measures.
UR - http://www.scopus.com/inward/record.url?scp=84958260391&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84958260391&partnerID=8YFLogxK
U2 - 10.1038/srep20692
DO - 10.1038/srep20692
M3 - Article
C2 - 26878913
AN - SCOPUS:84958260391
VL - 6
JO - Scientific Reports
JF - Scientific Reports
SN - 2045-2322
M1 - 20692
ER -