Alcoholic liver disease

focus on prodromal gut health

Byoungjin Park, Hye Ree Lee, Yongjae Lee

Research output: Contribution to journalReview article

8 Citations (Scopus)

Abstract

Alcoholic liver disease (ALD) is implicated in gut disturbances, both functionally and structurally. It has been noticed that the gut–liver interaction is an important feature in the prevention of systemic inflammation as well as liver health. The optimal functioning of the gut–liver axis depends on gut health. Therefore, gut problems may be important for estimating liver inflammation, while our knowledge of ALD could also provide an insight into gut health. Gut problems accompanied by ALD include gut motility and absorption problems, mucosal damage and the dysbiosis of gut microbiota and gastrointestinal carcinogenesis. Moreover, there is emerging evidence that besides direct inflammatory injury caused by alcohol, gut problems related to ALD play a crucial role in the pathogenesis of cardiovascular and immunological disorders. In this regard, we should consider ALD in relation to both gut health and chronic systemic low-grade inflammation. Accordingly, integrative therapeutic strategies are warranted for treating and preventing ALD and systemic inflammation as well as alcohol-related gut problems.

Original languageEnglish
Pages (from-to)493-500
Number of pages8
JournalJournal of Digestive Diseases
Volume17
Issue number8
DOIs
Publication statusPublished - 2016 Aug 1

Fingerprint

Alcoholic Liver Diseases
Health
Inflammation
Alcohols
Dysbiosis
Liver
Carcinogenesis
Wounds and Injuries

All Science Journal Classification (ASJC) codes

  • Gastroenterology

Cite this

Park, Byoungjin ; Lee, Hye Ree ; Lee, Yongjae. / Alcoholic liver disease : focus on prodromal gut health. In: Journal of Digestive Diseases. 2016 ; Vol. 17, No. 8. pp. 493-500.
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Alcoholic liver disease : focus on prodromal gut health. / Park, Byoungjin; Lee, Hye Ree; Lee, Yongjae.

In: Journal of Digestive Diseases, Vol. 17, No. 8, 01.08.2016, p. 493-500.

Research output: Contribution to journalReview article

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AU - Lee, Yongjae

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AB - Alcoholic liver disease (ALD) is implicated in gut disturbances, both functionally and structurally. It has been noticed that the gut–liver interaction is an important feature in the prevention of systemic inflammation as well as liver health. The optimal functioning of the gut–liver axis depends on gut health. Therefore, gut problems may be important for estimating liver inflammation, while our knowledge of ALD could also provide an insight into gut health. Gut problems accompanied by ALD include gut motility and absorption problems, mucosal damage and the dysbiosis of gut microbiota and gastrointestinal carcinogenesis. Moreover, there is emerging evidence that besides direct inflammatory injury caused by alcohol, gut problems related to ALD play a crucial role in the pathogenesis of cardiovascular and immunological disorders. In this regard, we should consider ALD in relation to both gut health and chronic systemic low-grade inflammation. Accordingly, integrative therapeutic strategies are warranted for treating and preventing ALD and systemic inflammation as well as alcohol-related gut problems.

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