Alkaloid glycosides and their cytotoxic constituents from Zanthoxylum nitidum

Nguyen Thi Hong Van; Tran Thi Tuyen; Pham Minh Quan; Pham Quoc Long; Nguyen Xuan Nhiem; Bui Huu Tai; Cam Thi Inh; Vu Dinh Hoang; Phan Van Kiem; Chau Van Minh; Seon Ju Park; Seung Hyun Kim

doi:10.1016/j.phytol.2019.04.022

Alkaloid glycosides and their cytotoxic constituents from Zanthoxylum nitidum

Nguyen Thi Hong Van, Tran Thi Tuyen, Pham Minh Quan, Pham Quoc Long, Nguyen Xuan Nhiem, Bui Huu Tai, Cam Thi Inh, Vu Dinh Hoang, Phan Van Kiem, Chau Van Minh, Seon Ju Park, Seung Hyun Kim

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Four new alkaloid glycosides, zanthonitisides A–D (1-4), together with five known compounds (5–9) were isolated from the aqueous fraction of stems and twigs of Zanthoxylum nitidum (Roxb.) DC. Their structures were determined on the basis of extensive spectroscopic methods, including 1D-, 2D-NMR, MS, and CD data. All isolated compounds were evaluated for their cytotoxic activity against three human cancer cell lines, CT-26, MCF-7, and MKN-45. As results, compound 4 showed significant cytotoxic activity on MKN-45 cancer cell line with IC₅₀ value of 7.4 ± 1.0 μM. Compound 9 exhibited moderate cytotoxic activity on all tested cancer cell lines with an IC₅₀ values ranging from 34.7 to 44.7 μM.

Original language	English
Pages (from-to)	47-51
Number of pages	5
Journal	Phytochemistry Letters
Volume	32
DOIs	https://doi.org/10.1016/j.phytol.2019.04.022
Publication status	Published - 2019 Aug

Bibliographical note

Funding Information:
This research is funded by Vietnam National Foundation for Science and Technology Development (NAFOSTED) under grant number 104.01-2015.44 . This research was supported by the National Research Foundation of Korea (NRF) grant [NRF- 2016R1A2B4006742 ] funded by the Ministry of Education, Science and Technology, Republic of Korea.

All Science Journal Classification (ASJC) codes

Biotechnology
Biochemistry
Agronomy and Crop Science
Plant Science

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@article{544d88959059425ba1e359e4a84e9965,

title = "Alkaloid glycosides and their cytotoxic constituents from Zanthoxylum nitidum",

abstract = "Four new alkaloid glycosides, zanthonitisides A–D (1-4), together with five known compounds (5–9) were isolated from the aqueous fraction of stems and twigs of Zanthoxylum nitidum (Roxb.) DC. Their structures were determined on the basis of extensive spectroscopic methods, including 1D-, 2D-NMR, MS, and CD data. All isolated compounds were evaluated for their cytotoxic activity against three human cancer cell lines, CT-26, MCF-7, and MKN-45. As results, compound 4 showed significant cytotoxic activity on MKN-45 cancer cell line with IC50 value of 7.4 ± 1.0 μM. Compound 9 exhibited moderate cytotoxic activity on all tested cancer cell lines with an IC50 values ranging from 34.7 to 44.7 μM.",

author = "Van, {Nguyen Thi Hong} and Tuyen, {Tran Thi} and Quan, {Pham Minh} and Long, {Pham Quoc} and Nhiem, {Nguyen Xuan} and Tai, {Bui Huu} and Inh, {Cam Thi} and Hoang, {Vu Dinh} and {Van Kiem}, Phan and {Van Minh}, Chau and Park, {Seon Ju} and Kim, {Seung Hyun}",

note = "Funding Information: This research is funded by Vietnam National Foundation for Science and Technology Development (NAFOSTED) under grant number 104.01-2015.44 . This research was supported by the National Research Foundation of Korea (NRF) grant [NRF- 2016R1A2B4006742 ] funded by the Ministry of Education, Science and Technology, Republic of Korea. ",

year = "2019",

month = aug,

doi = "10.1016/j.phytol.2019.04.022",

language = "English",

volume = "32",

pages = "47--51",

journal = "Phytochemistry Letters",

issn = "1874-3900",

publisher = "Elsevier BV",

}

Alkaloid glycosides and their cytotoxic constituents from Zanthoxylum nitidum. / Van, Nguyen Thi Hong; Tuyen, Tran Thi; Quan, Pham Minh; Long, Pham Quoc; Nhiem, Nguyen Xuan; Tai, Bui Huu; Inh, Cam Thi; Hoang, Vu Dinh; Van Kiem, Phan; Van Minh, Chau; Park, Seon Ju; Kim, Seung Hyun.

In: Phytochemistry Letters, Vol. 32, 08.2019, p. 47-51.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Alkaloid glycosides and their cytotoxic constituents from Zanthoxylum nitidum

AU - Van, Nguyen Thi Hong

AU - Tuyen, Tran Thi

AU - Quan, Pham Minh

AU - Long, Pham Quoc

AU - Nhiem, Nguyen Xuan

AU - Tai, Bui Huu

AU - Inh, Cam Thi

AU - Hoang, Vu Dinh

AU - Van Kiem, Phan

AU - Van Minh, Chau

AU - Park, Seon Ju

AU - Kim, Seung Hyun

N1 - Funding Information: This research is funded by Vietnam National Foundation for Science and Technology Development (NAFOSTED) under grant number 104.01-2015.44 . This research was supported by the National Research Foundation of Korea (NRF) grant [NRF- 2016R1A2B4006742 ] funded by the Ministry of Education, Science and Technology, Republic of Korea.

PY - 2019/8

Y1 - 2019/8

N2 - Four new alkaloid glycosides, zanthonitisides A–D (1-4), together with five known compounds (5–9) were isolated from the aqueous fraction of stems and twigs of Zanthoxylum nitidum (Roxb.) DC. Their structures were determined on the basis of extensive spectroscopic methods, including 1D-, 2D-NMR, MS, and CD data. All isolated compounds were evaluated for their cytotoxic activity against three human cancer cell lines, CT-26, MCF-7, and MKN-45. As results, compound 4 showed significant cytotoxic activity on MKN-45 cancer cell line with IC50 value of 7.4 ± 1.0 μM. Compound 9 exhibited moderate cytotoxic activity on all tested cancer cell lines with an IC50 values ranging from 34.7 to 44.7 μM.

AB - Four new alkaloid glycosides, zanthonitisides A–D (1-4), together with five known compounds (5–9) were isolated from the aqueous fraction of stems and twigs of Zanthoxylum nitidum (Roxb.) DC. Their structures were determined on the basis of extensive spectroscopic methods, including 1D-, 2D-NMR, MS, and CD data. All isolated compounds were evaluated for their cytotoxic activity against three human cancer cell lines, CT-26, MCF-7, and MKN-45. As results, compound 4 showed significant cytotoxic activity on MKN-45 cancer cell line with IC50 value of 7.4 ± 1.0 μM. Compound 9 exhibited moderate cytotoxic activity on all tested cancer cell lines with an IC50 values ranging from 34.7 to 44.7 μM.

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