Four new alkaloid glycosides, zanthonitisides A–D (1-4), together with five known compounds (5–9) were isolated from the aqueous fraction of stems and twigs of Zanthoxylum nitidum (Roxb.) DC. Their structures were determined on the basis of extensive spectroscopic methods, including 1D-, 2D-NMR, MS, and CD data. All isolated compounds were evaluated for their cytotoxic activity against three human cancer cell lines, CT-26, MCF-7, and MKN-45. As results, compound 4 showed significant cytotoxic activity on MKN-45 cancer cell line with IC50 value of 7.4 ± 1.0 μM. Compound 9 exhibited moderate cytotoxic activity on all tested cancer cell lines with an IC50 values ranging from 34.7 to 44.7 μM.
Bibliographical noteFunding Information:
This research is funded by Vietnam National Foundation for Science and Technology Development (NAFOSTED) under grant number 104.01-2015.44 . This research was supported by the National Research Foundation of Korea (NRF) grant [NRF- 2016R1A2B4006742 ] funded by the Ministry of Education, Science and Technology, Republic of Korea.
All Science Journal Classification (ASJC) codes
- Agronomy and Crop Science
- Plant Science