Alkaloid glycosides and their cytotoxic constituents from Zanthoxylum nitidum

Nguyen Thi Hong Van, Tran Thi Tuyen, Pham Minh Quan, Pham Quoc Long, Nguyen Xuan Nhiem, Bui Huu Tai, Cam Thi Inh, Vu Dinh Hoang, Phan Van Kiem, Chau Van Minh, Seon Ju Park, Seung Hyun Kim

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3 Citations (Scopus)

Abstract

Four new alkaloid glycosides, zanthonitisides A–D (1-4), together with five known compounds (5–9) were isolated from the aqueous fraction of stems and twigs of Zanthoxylum nitidum (Roxb.) DC. Their structures were determined on the basis of extensive spectroscopic methods, including 1D-, 2D-NMR, MS, and CD data. All isolated compounds were evaluated for their cytotoxic activity against three human cancer cell lines, CT-26, MCF-7, and MKN-45. As results, compound 4 showed significant cytotoxic activity on MKN-45 cancer cell line with IC50 value of 7.4 ± 1.0 μM. Compound 9 exhibited moderate cytotoxic activity on all tested cancer cell lines with an IC50 values ranging from 34.7 to 44.7 μM.

Original languageEnglish
Pages (from-to)47-51
Number of pages5
JournalPhytochemistry Letters
Volume32
DOIs
Publication statusPublished - 2019 Aug

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Biochemistry
  • Agronomy and Crop Science
  • Plant Science

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    Van, N. T. H., Tuyen, T. T., Quan, P. M., Long, P. Q., Nhiem, N. X., Tai, B. H., Inh, C. T., Hoang, V. D., Van Kiem, P., Van Minh, C., Park, S. J., & Kim, S. H. (2019). Alkaloid glycosides and their cytotoxic constituents from Zanthoxylum nitidum. Phytochemistry Letters, 32, 47-51. https://doi.org/10.1016/j.phytol.2019.04.022