Alkaloid glycosides and their cytotoxic constituents from Zanthoxylum nitidum

Nguyen Thi Hong Van, Tran Thi Tuyen, Pham Minh Quan, Pham Quoc Long, Nguyen Xuan Nhiem, Bui Huu Tai, Cam Thi Inh, Vu Dinh Hoang, Phan Van Kiem, Chau Van Minh, Seon Ju Park, Seung Hyun Kim

Research output: Contribution to journalArticle

Abstract

Four new alkaloid glycosides, zanthonitisides A–D (1-4), together with five known compounds (5–9) were isolated from the aqueous fraction of stems and twigs of Zanthoxylum nitidum (Roxb.) DC. Their structures were determined on the basis of extensive spectroscopic methods, including 1D-, 2D-NMR, MS, and CD data. All isolated compounds were evaluated for their cytotoxic activity against three human cancer cell lines, CT-26, MCF-7, and MKN-45. As results, compound 4 showed significant cytotoxic activity on MKN-45 cancer cell line with IC 50 value of 7.4 ± 1.0 μM. Compound 9 exhibited moderate cytotoxic activity on all tested cancer cell lines with an IC 50 values ranging from 34.7 to 44.7 μM.

Original languageEnglish
Pages (from-to)47-51
Number of pages5
JournalPhytochemistry Letters
Volume32
DOIs
Publication statusPublished - 2019 Aug 1

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Zanthoxylum
Glycosides
Alkaloids
glycosides
alkaloids
Cells
cell lines
Cell Line
inhibitory concentration 50
Neoplasms
Nuclear magnetic resonance
stems
Zanthoxylum nitidum
neoplasm cells
water
methodology

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Biochemistry
  • Agronomy and Crop Science
  • Plant Science

Cite this

Van, Nguyen Thi Hong ; Tuyen, Tran Thi ; Quan, Pham Minh ; Long, Pham Quoc ; Nhiem, Nguyen Xuan ; Tai, Bui Huu ; Inh, Cam Thi ; Hoang, Vu Dinh ; Van Kiem, Phan ; Van Minh, Chau ; Park, Seon Ju ; Kim, Seung Hyun. / Alkaloid glycosides and their cytotoxic constituents from Zanthoxylum nitidum. In: Phytochemistry Letters. 2019 ; Vol. 32. pp. 47-51.
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abstract = "Four new alkaloid glycosides, zanthonitisides A–D (1-4), together with five known compounds (5–9) were isolated from the aqueous fraction of stems and twigs of Zanthoxylum nitidum (Roxb.) DC. Their structures were determined on the basis of extensive spectroscopic methods, including 1D-, 2D-NMR, MS, and CD data. All isolated compounds were evaluated for their cytotoxic activity against three human cancer cell lines, CT-26, MCF-7, and MKN-45. As results, compound 4 showed significant cytotoxic activity on MKN-45 cancer cell line with IC 50 value of 7.4 ± 1.0 μM. Compound 9 exhibited moderate cytotoxic activity on all tested cancer cell lines with an IC 50 values ranging from 34.7 to 44.7 μM.",
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Van, NTH, Tuyen, TT, Quan, PM, Long, PQ, Nhiem, NX, Tai, BH, Inh, CT, Hoang, VD, Van Kiem, P, Van Minh, C, Park, SJ & Kim, SH 2019, 'Alkaloid glycosides and their cytotoxic constituents from Zanthoxylum nitidum', Phytochemistry Letters, vol. 32, pp. 47-51. https://doi.org/10.1016/j.phytol.2019.04.022

Alkaloid glycosides and their cytotoxic constituents from Zanthoxylum nitidum. / Van, Nguyen Thi Hong; Tuyen, Tran Thi; Quan, Pham Minh; Long, Pham Quoc; Nhiem, Nguyen Xuan; Tai, Bui Huu; Inh, Cam Thi; Hoang, Vu Dinh; Van Kiem, Phan; Van Minh, Chau; Park, Seon Ju; Kim, Seung Hyun.

In: Phytochemistry Letters, Vol. 32, 01.08.2019, p. 47-51.

Research output: Contribution to journalArticle

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T1 - Alkaloid glycosides and their cytotoxic constituents from Zanthoxylum nitidum

AU - Van, Nguyen Thi Hong

AU - Tuyen, Tran Thi

AU - Quan, Pham Minh

AU - Long, Pham Quoc

AU - Nhiem, Nguyen Xuan

AU - Tai, Bui Huu

AU - Inh, Cam Thi

AU - Hoang, Vu Dinh

AU - Van Kiem, Phan

AU - Van Minh, Chau

AU - Park, Seon Ju

AU - Kim, Seung Hyun

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