Abstract
Four new alkaloid glycosides, zanthonitisides A–D (1-4), together with five known compounds (5–9) were isolated from the aqueous fraction of stems and twigs of Zanthoxylum nitidum (Roxb.) DC. Their structures were determined on the basis of extensive spectroscopic methods, including 1D-, 2D-NMR, MS, and CD data. All isolated compounds were evaluated for their cytotoxic activity against three human cancer cell lines, CT-26, MCF-7, and MKN-45. As results, compound 4 showed significant cytotoxic activity on MKN-45 cancer cell line with IC50 value of 7.4 ± 1.0 μM. Compound 9 exhibited moderate cytotoxic activity on all tested cancer cell lines with an IC50 values ranging from 34.7 to 44.7 μM.
| Original language | English |
|---|---|
| Pages (from-to) | 47-51 |
| Number of pages | 5 |
| Journal | Phytochemistry Letters |
| Volume | 32 |
| DOIs | |
| Publication status | Published - 2019 Aug |
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All Science Journal Classification (ASJC) codes
- Biotechnology
- Biochemistry
- Agronomy and Crop Science
- Plant Science
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Alkaloid glycosides and their cytotoxic constituents from Zanthoxylum nitidum. / Van, Nguyen Thi Hong; Tuyen, Tran Thi; Quan, Pham Minh; Long, Pham Quoc; Nhiem, Nguyen Xuan; Tai, Bui Huu; Inh, Cam Thi; Hoang, Vu Dinh; Van Kiem, Phan; Van Minh, Chau; Park, Seon Ju; Kim, Seung Hyun.
In: Phytochemistry Letters, Vol. 32, 08.2019, p. 47-51.Research output: Contribution to journal › Article
TY - JOUR
T1 - Alkaloid glycosides and their cytotoxic constituents from Zanthoxylum nitidum
AU - Van, Nguyen Thi Hong
AU - Tuyen, Tran Thi
AU - Quan, Pham Minh
AU - Long, Pham Quoc
AU - Nhiem, Nguyen Xuan
AU - Tai, Bui Huu
AU - Inh, Cam Thi
AU - Hoang, Vu Dinh
AU - Van Kiem, Phan
AU - Van Minh, Chau
AU - Park, Seon Ju
AU - Kim, Seung Hyun
PY - 2019/8
Y1 - 2019/8
N2 - Four new alkaloid glycosides, zanthonitisides A–D (1-4), together with five known compounds (5–9) were isolated from the aqueous fraction of stems and twigs of Zanthoxylum nitidum (Roxb.) DC. Their structures were determined on the basis of extensive spectroscopic methods, including 1D-, 2D-NMR, MS, and CD data. All isolated compounds were evaluated for their cytotoxic activity against three human cancer cell lines, CT-26, MCF-7, and MKN-45. As results, compound 4 showed significant cytotoxic activity on MKN-45 cancer cell line with IC50 value of 7.4 ± 1.0 μM. Compound 9 exhibited moderate cytotoxic activity on all tested cancer cell lines with an IC50 values ranging from 34.7 to 44.7 μM.
AB - Four new alkaloid glycosides, zanthonitisides A–D (1-4), together with five known compounds (5–9) were isolated from the aqueous fraction of stems and twigs of Zanthoxylum nitidum (Roxb.) DC. Their structures were determined on the basis of extensive spectroscopic methods, including 1D-, 2D-NMR, MS, and CD data. All isolated compounds were evaluated for their cytotoxic activity against three human cancer cell lines, CT-26, MCF-7, and MKN-45. As results, compound 4 showed significant cytotoxic activity on MKN-45 cancer cell line with IC50 value of 7.4 ± 1.0 μM. Compound 9 exhibited moderate cytotoxic activity on all tested cancer cell lines with an IC50 values ranging from 34.7 to 44.7 μM.
UR - http://www.scopus.com/inward/record.url?scp=85065418082&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85065418082&partnerID=8YFLogxK
U2 - 10.1016/j.phytol.2019.04.022
DO - 10.1016/j.phytol.2019.04.022
M3 - Article
AN - SCOPUS:85065418082
VL - 32
SP - 47
EP - 51
JO - Phytochemistry Letters
JF - Phytochemistry Letters
SN - 1874-3900
ER -