A highly convergent synthetic approach to rotenoid natural products is described. Successful pairing of two building blocks for Sonogashira cross-coupling and intramolecular alkyne carbonyl metathesis allows ready access to 4-acylchromene, a key substructure of these natural products, leading to syntheses of (±)-deguelin and (±)-munduserone in high overall yields.
Bibliographical notePublisher Copyright:
© 2015 American Chemical Society.
All Science Journal Classification (ASJC) codes
- Organic Chemistry