All-in-One target-cell-specific magnetic nanoparticles for simultaneous molecular imaging and siRNA delivery

Jae Hyun Lee; Kyuri Lee; Seung Ho Moon; Yuhan Lee; Tae Gwan Park; Jinwoo Cheon

doi:10.1002/anie.200805998

All-in-One target-cell-specific magnetic nanoparticles for simultaneous molecular imaging and siRNA delivery

Jae Hyun Lee, Kyuri Lee, Seung Ho Moon, Yuhan Lee, Tae Gwan Park, Jinwoo Cheon

Research output: Contribution to journal › Article

288 Citations (Scopus)

Abstract

Cancer-cell-targeted gene silencing was observed with a magnetic-nanoparticle platform (MEIO, magnetism-engineered iron oxide) on which a fluorescent dye, siRNA, and a RGDpeptide targeting moiety were attached (see picture). The different functionalities enable the macroscopic (magnetic resonance) and microscopic (fluorescence) imaging of target cells. This system may be suitable for concurrent diagnostic and therapeutic applications.

Original language	English
Pages (from-to)	4174-4179
Number of pages	6
Journal	Angewandte Chemie - International Edition
Volume	48
Issue number	23
DOIs	https://doi.org/10.1002/anie.200805998
Publication status	Published - 2009 May 25

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All Science Journal Classification (ASJC) codes

Catalysis
Chemistry(all)

Cite this

Lee, J. H., Lee, K., Moon, S. H., Lee, Y., Park, T. G., & Cheon, J. (2009). All-in-One target-cell-specific magnetic nanoparticles for simultaneous molecular imaging and siRNA delivery. Angewandte Chemie - International Edition, 48(23), 4174-4179. https://doi.org/10.1002/anie.200805998

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10.1002/anie.200805998