All-in-One target-cell-specific magnetic nanoparticles for simultaneous molecular imaging and siRNA delivery

Jae Hyun Lee, Kyuri Lee, Seung Ho Moon, Yuhan Lee, Tae Gwan Park, Jinwoo Cheon

Research output: Contribution to journalArticle

281 Citations (Scopus)

Abstract

Cancer-cell-targeted gene silencing was observed with a magnetic-nanoparticle platform (MEIO, magnetism-engineered iron oxide) on which a fluorescent dye, siRNA, and a RGDpeptide targeting moiety were attached (see picture). The different functionalities enable the macroscopic (magnetic resonance) and microscopic (fluorescence) imaging of target cells. This system may be suitable for concurrent diagnostic and therapeutic applications.

Original languageEnglish
Pages (from-to)4174-4179
Number of pages6
JournalAngewandte Chemie - International Edition
Volume48
Issue number23
DOIs
Publication statusPublished - 2009 May 25

Fingerprint

Molecular imaging
Magnetism
Magnetic resonance
Iron oxides
Fluorescent Dyes
Small Interfering RNA
Dyes
Genes
Fluorescence
Nanoparticles
Imaging techniques
ferric oxide

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)

Cite this

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All-in-One target-cell-specific magnetic nanoparticles for simultaneous molecular imaging and siRNA delivery. / Lee, Jae Hyun; Lee, Kyuri; Moon, Seung Ho; Lee, Yuhan; Park, Tae Gwan; Cheon, Jinwoo.

In: Angewandte Chemie - International Edition, Vol. 48, No. 23, 25.05.2009, p. 4174-4179.

Research output: Contribution to journalArticle

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