Abstract
Cancer-cell-targeted gene silencing was observed with a magnetic-nanoparticle platform (MEIO, magnetism-engineered iron oxide) on which a fluorescent dye, siRNA, and a RGDpeptide targeting moiety were attached (see picture). The different functionalities enable the macroscopic (magnetic resonance) and microscopic (fluorescence) imaging of target cells. This system may be suitable for concurrent diagnostic and therapeutic applications.
| Original language | English |
|---|---|
| Pages (from-to) | 4174-4179 |
| Number of pages | 6 |
| Journal | Angewandte Chemie - International Edition |
| Volume | 48 |
| Issue number | 23 |
| DOIs | |
| Publication status | Published - 2009 May 25 |
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All Science Journal Classification (ASJC) codes
- Catalysis
- Chemistry(all)
Cite this
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All-in-One target-cell-specific magnetic nanoparticles for simultaneous molecular imaging and siRNA delivery. / Lee, Jae Hyun; Lee, Kyuri; Moon, Seung Ho; Lee, Yuhan; Park, Tae Gwan; Cheon, Jinwoo.
In: Angewandte Chemie - International Edition, Vol. 48, No. 23, 25.05.2009, p. 4174-4179.Research output: Contribution to journal › Article
TY - JOUR
T1 - All-in-One target-cell-specific magnetic nanoparticles for simultaneous molecular imaging and siRNA delivery
AU - Lee, Jae Hyun
AU - Lee, Kyuri
AU - Moon, Seung Ho
AU - Lee, Yuhan
AU - Park, Tae Gwan
AU - Cheon, Jinwoo
PY - 2009/5/25
Y1 - 2009/5/25
N2 - Cancer-cell-targeted gene silencing was observed with a magnetic-nanoparticle platform (MEIO, magnetism-engineered iron oxide) on which a fluorescent dye, siRNA, and a RGDpeptide targeting moiety were attached (see picture). The different functionalities enable the macroscopic (magnetic resonance) and microscopic (fluorescence) imaging of target cells. This system may be suitable for concurrent diagnostic and therapeutic applications.
AB - Cancer-cell-targeted gene silencing was observed with a magnetic-nanoparticle platform (MEIO, magnetism-engineered iron oxide) on which a fluorescent dye, siRNA, and a RGDpeptide targeting moiety were attached (see picture). The different functionalities enable the macroscopic (magnetic resonance) and microscopic (fluorescence) imaging of target cells. This system may be suitable for concurrent diagnostic and therapeutic applications.
UR - http://www.scopus.com/inward/record.url?scp=70349964558&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=70349964558&partnerID=8YFLogxK
U2 - 10.1002/anie.200805998
DO - 10.1002/anie.200805998
M3 - Article
C2 - 19408274
AN - SCOPUS:70349964558
VL - 48
SP - 4174
EP - 4179
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
SN - 1433-7851
IS - 23
ER -