Abstract
Cancer-cell-targeted gene silencing was observed with a magnetic-nanoparticle platform (MEIO, magnetism-engineered iron oxide) on which a fluorescent dye, siRNA, and a RGDpeptide targeting moiety were attached (see picture). The different functionalities enable the macroscopic (magnetic resonance) and microscopic (fluorescence) imaging of target cells. This system may be suitable for concurrent diagnostic and therapeutic applications.
| Original language | English |
|---|---|
| Pages (from-to) | 4174-4179 |
| Number of pages | 6 |
| Journal | Angewandte Chemie - International Edition |
| Volume | 48 |
| Issue number | 23 |
| DOIs | |
| Publication status | Published - 2009 May 25 |
All Science Journal Classification (ASJC) codes
- Catalysis
- Chemistry(all)
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Lee, J. H., Lee, K., Moon, S. H., Lee, Y., Park, T. G., & Cheon, J. (2009). All-in-One target-cell-specific magnetic nanoparticles for simultaneous molecular imaging and siRNA delivery. Angewandte Chemie - International Edition, 48(23), 4174-4179. https://doi.org/10.1002/anie.200805998