Alpha amplitude and phase locking in obsessive-compulsive disorder during working memory

Jin Young Park, Jaewon Lee, Hae Jeong Park, Jae Jin Kim, Kee Namkoong, Se Joo Kim

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Alpha event-related desynchronization (ERD) and synchronization are known to reflect brain activation and inhibition, respectively. Alpha phase locking seems to reflect the timing in the cortical process. In a previous study, lower alpha ERD was related to working memory in obsessive-compulsive disorder (OCD) patients than in controls during the retention and retrival phases, but not in the encoding phase. However, memory deficits in OCD patients are known to be related to executive failure during the encoding phase. Thus, focusing on the encoding phase, we tested the level of alpha amplitude and phase locking in OCD patients according to memory load. The EEGs of fifteen OCD patients and fifteen controls were recorded during a Sternberg working memory task. The behavioral performance of the OCD patients was normal. However, the OCD group yielded significantly lower ERD and stronger phase locking. As memory load rose, ERD and phase locking significantly increased in both groups. A difference in event-related alpha oscillation was observed in the encoding phase. Lower alpha modulation in the OCD patient simplied abnormality of the excitatory/inhibitory process in the brain, and increased phase locking might reflect excessive attentional excitability.

Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalInternational Journal of Psychophysiology
Volume83
Issue number1
DOIs
Publication statusPublished - 2012 Jan 1

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Neuropsychology and Physiological Psychology
  • Physiology (medical)

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