Alpha-fetoprotein-producing gastric cancer

Ruth Lee, SunYoung Rha, Joong Bae Ahn, Kwang Yong Shim, Jin Hyuk Choi, H. O. Young Lim, Nae Choon Yoo, Sung Hoon Noh, Joo Hang Kim, Jae Kyung Roh, Jin Sik Min, Byung Soo Kim, Hyuncheol Chung

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

We measured the sero-positivity rate of serum α-fetoprotein (αFP) of gastric cancer patients by ELISA assay; forty-two curatively resected patients, 14 palliatively resected patients, 8 who received explo-laparotomy or bypass surgery and 18 patients with systemic metastasis. The sero-positive rate was 9.8% (8/82) and the positivity increased with cancer progression. Sex, age and pathological type were similar between αFP-positive and - negative patients. The overall synchronous hepatic metastasis rates in αFP- positive and αFP-negative groups were 37.5% (3/8) and 12.2% (9/74), respectively (p=0.08). The predictability of synchronous liver metastasis in eight αFP-positive patients were as follows: 37.5% of total patients (3/8), 50.0% (3/6) of unresectable patients, and 60.0% (3/5) of patients with systemic metastasis. In three αFP-positive patient with liver metastasis, all the hepatic lesions were intrahepatic and multiple, while in αFP- negative patients, 67% (6/9) of the hepatic lesions was single intrahepatic lesion or surface nodule. The predictability of both synchronous and metachronous liver metastasis in αFP-positive gastric cancer patients was 75%. These findings suggested that, in advanced stomach cancer patients, especially in stage IV, αFP can be used in predicting liver metastasis during follow-up.

Original languageEnglish
Pages (from-to)1179-1184
Number of pages6
JournalOncology Reports
Volume5
Issue number5
Publication statusPublished - 1998 Aug 24

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alpha-Fetoproteins
Fetal Proteins
Stomach Neoplasms
Neoplasm Metastasis
Liver
Laparotomy
Enzyme-Linked Immunosorbent Assay

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Lee, R., Rha, S., Ahn, J. B., Shim, K. Y., Choi, J. H., Young Lim, H. O., ... Chung, H. (1998). Alpha-fetoprotein-producing gastric cancer. Oncology Reports, 5(5), 1179-1184.
Lee, Ruth ; Rha, SunYoung ; Ahn, Joong Bae ; Shim, Kwang Yong ; Choi, Jin Hyuk ; Young Lim, H. O. ; Yoo, Nae Choon ; Noh, Sung Hoon ; Kim, Joo Hang ; Roh, Jae Kyung ; Min, Jin Sik ; Kim, Byung Soo ; Chung, Hyuncheol. / Alpha-fetoprotein-producing gastric cancer. In: Oncology Reports. 1998 ; Vol. 5, No. 5. pp. 1179-1184.
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title = "Alpha-fetoprotein-producing gastric cancer",
abstract = "We measured the sero-positivity rate of serum α-fetoprotein (αFP) of gastric cancer patients by ELISA assay; forty-two curatively resected patients, 14 palliatively resected patients, 8 who received explo-laparotomy or bypass surgery and 18 patients with systemic metastasis. The sero-positive rate was 9.8{\%} (8/82) and the positivity increased with cancer progression. Sex, age and pathological type were similar between αFP-positive and - negative patients. The overall synchronous hepatic metastasis rates in αFP- positive and αFP-negative groups were 37.5{\%} (3/8) and 12.2{\%} (9/74), respectively (p=0.08). The predictability of synchronous liver metastasis in eight αFP-positive patients were as follows: 37.5{\%} of total patients (3/8), 50.0{\%} (3/6) of unresectable patients, and 60.0{\%} (3/5) of patients with systemic metastasis. In three αFP-positive patient with liver metastasis, all the hepatic lesions were intrahepatic and multiple, while in αFP- negative patients, 67{\%} (6/9) of the hepatic lesions was single intrahepatic lesion or surface nodule. The predictability of both synchronous and metachronous liver metastasis in αFP-positive gastric cancer patients was 75{\%}. These findings suggested that, in advanced stomach cancer patients, especially in stage IV, αFP can be used in predicting liver metastasis during follow-up.",
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Lee, R, Rha, S, Ahn, JB, Shim, KY, Choi, JH, Young Lim, HO, Yoo, NC, Noh, SH, Kim, JH, Roh, JK, Min, JS, Kim, BS & Chung, H 1998, 'Alpha-fetoprotein-producing gastric cancer', Oncology Reports, vol. 5, no. 5, pp. 1179-1184.

Alpha-fetoprotein-producing gastric cancer. / Lee, Ruth; Rha, SunYoung; Ahn, Joong Bae; Shim, Kwang Yong; Choi, Jin Hyuk; Young Lim, H. O.; Yoo, Nae Choon; Noh, Sung Hoon; Kim, Joo Hang; Roh, Jae Kyung; Min, Jin Sik; Kim, Byung Soo; Chung, Hyuncheol.

In: Oncology Reports, Vol. 5, No. 5, 24.08.1998, p. 1179-1184.

Research output: Contribution to journalArticle

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AU - Lee, Ruth

AU - Rha, SunYoung

AU - Ahn, Joong Bae

AU - Shim, Kwang Yong

AU - Choi, Jin Hyuk

AU - Young Lim, H. O.

AU - Yoo, Nae Choon

AU - Noh, Sung Hoon

AU - Kim, Joo Hang

AU - Roh, Jae Kyung

AU - Min, Jin Sik

AU - Kim, Byung Soo

AU - Chung, Hyuncheol

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AB - We measured the sero-positivity rate of serum α-fetoprotein (αFP) of gastric cancer patients by ELISA assay; forty-two curatively resected patients, 14 palliatively resected patients, 8 who received explo-laparotomy or bypass surgery and 18 patients with systemic metastasis. The sero-positive rate was 9.8% (8/82) and the positivity increased with cancer progression. Sex, age and pathological type were similar between αFP-positive and - negative patients. The overall synchronous hepatic metastasis rates in αFP- positive and αFP-negative groups were 37.5% (3/8) and 12.2% (9/74), respectively (p=0.08). The predictability of synchronous liver metastasis in eight αFP-positive patients were as follows: 37.5% of total patients (3/8), 50.0% (3/6) of unresectable patients, and 60.0% (3/5) of patients with systemic metastasis. In three αFP-positive patient with liver metastasis, all the hepatic lesions were intrahepatic and multiple, while in αFP- negative patients, 67% (6/9) of the hepatic lesions was single intrahepatic lesion or surface nodule. The predictability of both synchronous and metachronous liver metastasis in αFP-positive gastric cancer patients was 75%. These findings suggested that, in advanced stomach cancer patients, especially in stage IV, αFP can be used in predicting liver metastasis during follow-up.

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Lee R, Rha S, Ahn JB, Shim KY, Choi JH, Young Lim HO et al. Alpha-fetoprotein-producing gastric cancer. Oncology Reports. 1998 Aug 24;5(5):1179-1184.