Alteration of BMP-4 and Runx2 expression patterns in mouse temporomandibular joint after ovariectomy

H. J. Min, M. J. Lee, J. Y. Kim, S. W. Cho, H. D. Park, S. I. Lee, H. J. Kim, H. S. Jung

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Objective: Temporomandibular disorder (TMD) includes a number of clinical conditions involving the masticatory musculature or the temporomandibular joint (TMJ) and associated structures. Previous studies have shown the presence of high-affinity estrogen receptors in the TMJ articular cartilage. The aim of this study was to evaluate the developmental changes in mouse TMJ under estrogen deficiency. Materials and methods: Four-month-old ovariectomized mice were killed after certain weeks. We examined the significant alterations of the expression patterns of bone morphogenetic protein (BMP)-4, Runx2, and bone sialoprotein (BSP) after ovariectomy. Results: In the control group, BMP-4, Runx2, and BSP expressions showed no definite difference at any stage. In the ovariectomy group, the intensity of BMP-4 and Runx2 expression increased after ovariectomy. BSP immunoreactivity, however, increased slightly at 2 weeks but then decreased gradually. Conclusions: Estrogen plays important roles in the metabolism and maintenance of TMJ via regulations of signaling molecules such as BMP-4, Runx2, and BSP. Our results suggest that estrogen deficiency is a candidate cause of TMD. This study revealed further osteogenetic properties of estrogen that may be useful in the clinical treatment and prevention of TMD.

Original languageEnglish
Pages (from-to)220-227
Number of pages8
JournalOral Diseases
Volume13
Issue number2
DOIs
Publication statusPublished - 2007 Mar 1

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Integrin-Binding Sialoprotein
Bone Morphogenetic Protein 4
Temporomandibular Joint
Ovariectomy
Temporomandibular Joint Disorders
Estrogens
Articular Cartilage
Estrogen Receptors
Maintenance
Control Groups

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology
  • Dentistry(all)

Cite this

Min, H. J. ; Lee, M. J. ; Kim, J. Y. ; Cho, S. W. ; Park, H. D. ; Lee, S. I. ; Kim, H. J. ; Jung, H. S. / Alteration of BMP-4 and Runx2 expression patterns in mouse temporomandibular joint after ovariectomy. In: Oral Diseases. 2007 ; Vol. 13, No. 2. pp. 220-227.
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Alteration of BMP-4 and Runx2 expression patterns in mouse temporomandibular joint after ovariectomy. / Min, H. J.; Lee, M. J.; Kim, J. Y.; Cho, S. W.; Park, H. D.; Lee, S. I.; Kim, H. J.; Jung, H. S.

In: Oral Diseases, Vol. 13, No. 2, 01.03.2007, p. 220-227.

Research output: Contribution to journalArticle

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AU - Min, H. J.

AU - Lee, M. J.

AU - Kim, J. Y.

AU - Cho, S. W.

AU - Park, H. D.

AU - Lee, S. I.

AU - Kim, H. J.

AU - Jung, H. S.

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N2 - Objective: Temporomandibular disorder (TMD) includes a number of clinical conditions involving the masticatory musculature or the temporomandibular joint (TMJ) and associated structures. Previous studies have shown the presence of high-affinity estrogen receptors in the TMJ articular cartilage. The aim of this study was to evaluate the developmental changes in mouse TMJ under estrogen deficiency. Materials and methods: Four-month-old ovariectomized mice were killed after certain weeks. We examined the significant alterations of the expression patterns of bone morphogenetic protein (BMP)-4, Runx2, and bone sialoprotein (BSP) after ovariectomy. Results: In the control group, BMP-4, Runx2, and BSP expressions showed no definite difference at any stage. In the ovariectomy group, the intensity of BMP-4 and Runx2 expression increased after ovariectomy. BSP immunoreactivity, however, increased slightly at 2 weeks but then decreased gradually. Conclusions: Estrogen plays important roles in the metabolism and maintenance of TMJ via regulations of signaling molecules such as BMP-4, Runx2, and BSP. Our results suggest that estrogen deficiency is a candidate cause of TMD. This study revealed further osteogenetic properties of estrogen that may be useful in the clinical treatment and prevention of TMD.

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