Altered compliance and residual strain precede angiographically detectable early atherosclerosis in low-density lipoprotein receptor deficiency

Myeongki Hong, J. Vossoughi, G. S. Mintz, R. D. Kauffman, Jr Hoyt, J. F. Cornhill, E. E. Herderick, M. B. Leon, J. M. Hoeg

Research output: Contribution to journalArticle

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Abstract

Background: This study was performed to detect changes in vascular biomechanical properties early in atherogenesis. Methods and Results: Age- and weight-matched LDL-receptor deficient Watanabe hypercholesterolemic male rabbits (Group I: n=11) and normal rabbits (Group II: n=11) were studied. Fasting plasma lipoprotein concentrations, aortic angiography and intravascular ultrasound, in vivo aortic compliance evaluation, ex vivo aortic residual strain measurements, aortic lipid content and histopathology were determined. Plasma cholesterol was increased 9.8 fold and aortic cholesterol content was increased from 20 to 43 fold in Group I compared to Group II, respectively (P<.00005). Angiography revealed no stenoses in either group, whereas intravascular ultrasound and histological studies of Group I showed small circumferential plaques with <10% cross-sectional area involvement. The residual strain in Group I was significantly increased in the ascending thoracic aorta (22.1±6.9% versus 10.4±3.2% in Group II, P<.0001), descending thoracic aorta (15.7±7.2% versus 4.8±1.3% in Group II, P<.0001), and abdominal aorta (18.0±4.8% versus 8.3± 6.3% in Group II, P<.005). Changes in residual strain were inversely correlated with the aortic cholesterol content in the ascending thoracic aorta (r=72; P=-.001), descending thoracic aorta (r=-.95; P<.001), and abdominal aorta (r=-.51; P=.019). Conclusions: Early atherosclerosis in LDL-receptor deficient rabbits, undetectable by angiography yet observed by intravascular ultrasound imaging and histology, is associated with marked changes in ex vivo residual strain. Alterations in vascular biomechanical properties, associated with changes in cholesterol content, may have physiologic consequences and may be useful in detecting and quantitating early atherosclerosis.

Original languageEnglish
Pages (from-to)2209-2217
Number of pages9
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Volume17
Issue number10
DOIs
Publication statusPublished - 1997 Jan 1

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LDL Receptors
Thoracic Aorta
Compliance
Atherosclerosis
Cholesterol
Angiography
Abdominal Aorta
Rabbits
Blood Vessels
Aorta
Lipoproteins
Fasting
Ultrasonography
Histology
Pathologic Constriction
Lipids
Weights and Measures

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Hong, Myeongki ; Vossoughi, J. ; Mintz, G. S. ; Kauffman, R. D. ; Hoyt, Jr ; Cornhill, J. F. ; Herderick, E. E. ; Leon, M. B. ; Hoeg, J. M. / Altered compliance and residual strain precede angiographically detectable early atherosclerosis in low-density lipoprotein receptor deficiency. In: Arteriosclerosis, Thrombosis, and Vascular Biology. 1997 ; Vol. 17, No. 10. pp. 2209-2217.
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title = "Altered compliance and residual strain precede angiographically detectable early atherosclerosis in low-density lipoprotein receptor deficiency",
abstract = "Background: This study was performed to detect changes in vascular biomechanical properties early in atherogenesis. Methods and Results: Age- and weight-matched LDL-receptor deficient Watanabe hypercholesterolemic male rabbits (Group I: n=11) and normal rabbits (Group II: n=11) were studied. Fasting plasma lipoprotein concentrations, aortic angiography and intravascular ultrasound, in vivo aortic compliance evaluation, ex vivo aortic residual strain measurements, aortic lipid content and histopathology were determined. Plasma cholesterol was increased 9.8 fold and aortic cholesterol content was increased from 20 to 43 fold in Group I compared to Group II, respectively (P<.00005). Angiography revealed no stenoses in either group, whereas intravascular ultrasound and histological studies of Group I showed small circumferential plaques with <10{\%} cross-sectional area involvement. The residual strain in Group I was significantly increased in the ascending thoracic aorta (22.1±6.9{\%} versus 10.4±3.2{\%} in Group II, P<.0001), descending thoracic aorta (15.7±7.2{\%} versus 4.8±1.3{\%} in Group II, P<.0001), and abdominal aorta (18.0±4.8{\%} versus 8.3± 6.3{\%} in Group II, P<.005). Changes in residual strain were inversely correlated with the aortic cholesterol content in the ascending thoracic aorta (r=72; P=-.001), descending thoracic aorta (r=-.95; P<.001), and abdominal aorta (r=-.51; P=.019). Conclusions: Early atherosclerosis in LDL-receptor deficient rabbits, undetectable by angiography yet observed by intravascular ultrasound imaging and histology, is associated with marked changes in ex vivo residual strain. Alterations in vascular biomechanical properties, associated with changes in cholesterol content, may have physiologic consequences and may be useful in detecting and quantitating early atherosclerosis.",
author = "Myeongki Hong and J. Vossoughi and Mintz, {G. S.} and Kauffman, {R. D.} and Jr Hoyt and Cornhill, {J. F.} and Herderick, {E. E.} and Leon, {M. B.} and Hoeg, {J. M.}",
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Altered compliance and residual strain precede angiographically detectable early atherosclerosis in low-density lipoprotein receptor deficiency. / Hong, Myeongki; Vossoughi, J.; Mintz, G. S.; Kauffman, R. D.; Hoyt, Jr; Cornhill, J. F.; Herderick, E. E.; Leon, M. B.; Hoeg, J. M.

In: Arteriosclerosis, Thrombosis, and Vascular Biology, Vol. 17, No. 10, 01.01.1997, p. 2209-2217.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Altered compliance and residual strain precede angiographically detectable early atherosclerosis in low-density lipoprotein receptor deficiency

AU - Hong, Myeongki

AU - Vossoughi, J.

AU - Mintz, G. S.

AU - Kauffman, R. D.

AU - Hoyt, Jr

AU - Cornhill, J. F.

AU - Herderick, E. E.

AU - Leon, M. B.

AU - Hoeg, J. M.

PY - 1997/1/1

Y1 - 1997/1/1

N2 - Background: This study was performed to detect changes in vascular biomechanical properties early in atherogenesis. Methods and Results: Age- and weight-matched LDL-receptor deficient Watanabe hypercholesterolemic male rabbits (Group I: n=11) and normal rabbits (Group II: n=11) were studied. Fasting plasma lipoprotein concentrations, aortic angiography and intravascular ultrasound, in vivo aortic compliance evaluation, ex vivo aortic residual strain measurements, aortic lipid content and histopathology were determined. Plasma cholesterol was increased 9.8 fold and aortic cholesterol content was increased from 20 to 43 fold in Group I compared to Group II, respectively (P<.00005). Angiography revealed no stenoses in either group, whereas intravascular ultrasound and histological studies of Group I showed small circumferential plaques with <10% cross-sectional area involvement. The residual strain in Group I was significantly increased in the ascending thoracic aorta (22.1±6.9% versus 10.4±3.2% in Group II, P<.0001), descending thoracic aorta (15.7±7.2% versus 4.8±1.3% in Group II, P<.0001), and abdominal aorta (18.0±4.8% versus 8.3± 6.3% in Group II, P<.005). Changes in residual strain were inversely correlated with the aortic cholesterol content in the ascending thoracic aorta (r=72; P=-.001), descending thoracic aorta (r=-.95; P<.001), and abdominal aorta (r=-.51; P=.019). Conclusions: Early atherosclerosis in LDL-receptor deficient rabbits, undetectable by angiography yet observed by intravascular ultrasound imaging and histology, is associated with marked changes in ex vivo residual strain. Alterations in vascular biomechanical properties, associated with changes in cholesterol content, may have physiologic consequences and may be useful in detecting and quantitating early atherosclerosis.

AB - Background: This study was performed to detect changes in vascular biomechanical properties early in atherogenesis. Methods and Results: Age- and weight-matched LDL-receptor deficient Watanabe hypercholesterolemic male rabbits (Group I: n=11) and normal rabbits (Group II: n=11) were studied. Fasting plasma lipoprotein concentrations, aortic angiography and intravascular ultrasound, in vivo aortic compliance evaluation, ex vivo aortic residual strain measurements, aortic lipid content and histopathology were determined. Plasma cholesterol was increased 9.8 fold and aortic cholesterol content was increased from 20 to 43 fold in Group I compared to Group II, respectively (P<.00005). Angiography revealed no stenoses in either group, whereas intravascular ultrasound and histological studies of Group I showed small circumferential plaques with <10% cross-sectional area involvement. The residual strain in Group I was significantly increased in the ascending thoracic aorta (22.1±6.9% versus 10.4±3.2% in Group II, P<.0001), descending thoracic aorta (15.7±7.2% versus 4.8±1.3% in Group II, P<.0001), and abdominal aorta (18.0±4.8% versus 8.3± 6.3% in Group II, P<.005). Changes in residual strain were inversely correlated with the aortic cholesterol content in the ascending thoracic aorta (r=72; P=-.001), descending thoracic aorta (r=-.95; P<.001), and abdominal aorta (r=-.51; P=.019). Conclusions: Early atherosclerosis in LDL-receptor deficient rabbits, undetectable by angiography yet observed by intravascular ultrasound imaging and histology, is associated with marked changes in ex vivo residual strain. Alterations in vascular biomechanical properties, associated with changes in cholesterol content, may have physiologic consequences and may be useful in detecting and quantitating early atherosclerosis.

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U2 - 10.1161/01.ATV.17.10.2209

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