Altered functional connectivity in idiopathic rapid eye movement sleep behavior disorder: A resting-state EEG study

Jun Sang Sunwoo, Sanghun Lee, Jung Hoon Kim, Jung Ah Lim, Tae Joon Kim, Jung Ick Byun, Min Hee Jeong, Kwang Su Cha, Jeong Woo Choi, Kyung Hwan Kim, Soon Tae Lee, Keun Hwa Jung, Kyung Il Park, Kon Chu, Manho Kim, Sang Kun Lee, Ki Young Jung

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Study Objectives: Idiopathic rapid eye movement sleep behavior disorder (iRBD) is considered as a prodromal stage of synucleinopathy. Although loss of functional connectivity is implicated in neurodegenerative diseases, network characteristics of electroencephalography (EEG) in iRBD are unknown. Therefore, we evaluated resting-state EEG functional connectivity to identify the brain network changes in patients with iRBD. Methods: We prospectively enrolled 20 patients with polysomnography-confirmed iRBD and 16 controls. Four patients with mild cognitive impairment were excluded from the analysis after cognitive function tests. EEG was recorded during relaxed wakefulness. We computed the weighted phase lag index as a measure of functional connectivity from EEG recordings. Results: All patients with iRBD (mean age 64.3 years; men, 68.8%) had no overt manifestations of neurodegenerative diseases such as Parkinsonism or dementia. The mean duration from symptom onset was 4.8 years. Overall connectivity strength did not differ between the two groups in all frequency bands. However, comparisons of each functional connection with the nonparametric permutation test demonstrated iRBD had decreased delta-band functional connectivity in the frontal regions. There were no significantly increased functional connections in all frequencies. The altered connections had a significant correlation with RBD questionnaire scores. Notably, delta-band weighted phase lag index between left frontal and central regions was correlated with verbal fluency performance (r = 0.486, p = .007). Conclusions: Resting-state brain network of iRBD was characterized by a loss of delta-band functional connectivity. Therefore, functional networks in iRBD are altered at the early phase of disease.

Original languageEnglish
JournalSleep
Volume40
Issue number6
DOIs
Publication statusPublished - 2017 Jun

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REM Sleep Behavior Disorder
Electroencephalography
Neurodegenerative Diseases
Prodromal Symptoms
Polysomnography
Wakefulness
Brain
Parkinsonian Disorders
Cognition
Dementia

All Science Journal Classification (ASJC) codes

  • Clinical Neurology
  • Physiology (medical)

Cite this

Sunwoo, J. S., Lee, S., Kim, J. H., Lim, J. A., Kim, T. J., Byun, J. I., ... Jung, K. Y. (2017). Altered functional connectivity in idiopathic rapid eye movement sleep behavior disorder: A resting-state EEG study. Sleep, 40(6). https://doi.org/10.1093/sleep/zsx058
Sunwoo, Jun Sang ; Lee, Sanghun ; Kim, Jung Hoon ; Lim, Jung Ah ; Kim, Tae Joon ; Byun, Jung Ick ; Jeong, Min Hee ; Cha, Kwang Su ; Choi, Jeong Woo ; Kim, Kyung Hwan ; Lee, Soon Tae ; Jung, Keun Hwa ; Park, Kyung Il ; Chu, Kon ; Kim, Manho ; Lee, Sang Kun ; Jung, Ki Young. / Altered functional connectivity in idiopathic rapid eye movement sleep behavior disorder : A resting-state EEG study. In: Sleep. 2017 ; Vol. 40, No. 6.
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title = "Altered functional connectivity in idiopathic rapid eye movement sleep behavior disorder: A resting-state EEG study",
abstract = "Study Objectives: Idiopathic rapid eye movement sleep behavior disorder (iRBD) is considered as a prodromal stage of synucleinopathy. Although loss of functional connectivity is implicated in neurodegenerative diseases, network characteristics of electroencephalography (EEG) in iRBD are unknown. Therefore, we evaluated resting-state EEG functional connectivity to identify the brain network changes in patients with iRBD. Methods: We prospectively enrolled 20 patients with polysomnography-confirmed iRBD and 16 controls. Four patients with mild cognitive impairment were excluded from the analysis after cognitive function tests. EEG was recorded during relaxed wakefulness. We computed the weighted phase lag index as a measure of functional connectivity from EEG recordings. Results: All patients with iRBD (mean age 64.3 years; men, 68.8{\%}) had no overt manifestations of neurodegenerative diseases such as Parkinsonism or dementia. The mean duration from symptom onset was 4.8 years. Overall connectivity strength did not differ between the two groups in all frequency bands. However, comparisons of each functional connection with the nonparametric permutation test demonstrated iRBD had decreased delta-band functional connectivity in the frontal regions. There were no significantly increased functional connections in all frequencies. The altered connections had a significant correlation with RBD questionnaire scores. Notably, delta-band weighted phase lag index between left frontal and central regions was correlated with verbal fluency performance (r = 0.486, p = .007). Conclusions: Resting-state brain network of iRBD was characterized by a loss of delta-band functional connectivity. Therefore, functional networks in iRBD are altered at the early phase of disease.",
author = "Sunwoo, {Jun Sang} and Sanghun Lee and Kim, {Jung Hoon} and Lim, {Jung Ah} and Kim, {Tae Joon} and Byun, {Jung Ick} and Jeong, {Min Hee} and Cha, {Kwang Su} and Choi, {Jeong Woo} and Kim, {Kyung Hwan} and Lee, {Soon Tae} and Jung, {Keun Hwa} and Park, {Kyung Il} and Kon Chu and Manho Kim and Lee, {Sang Kun} and Jung, {Ki Young}",
year = "2017",
month = "6",
doi = "10.1093/sleep/zsx058",
language = "English",
volume = "40",
journal = "Sleep",
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Sunwoo, JS, Lee, S, Kim, JH, Lim, JA, Kim, TJ, Byun, JI, Jeong, MH, Cha, KS, Choi, JW, Kim, KH, Lee, ST, Jung, KH, Park, KI, Chu, K, Kim, M, Lee, SK & Jung, KY 2017, 'Altered functional connectivity in idiopathic rapid eye movement sleep behavior disorder: A resting-state EEG study', Sleep, vol. 40, no. 6. https://doi.org/10.1093/sleep/zsx058

Altered functional connectivity in idiopathic rapid eye movement sleep behavior disorder : A resting-state EEG study. / Sunwoo, Jun Sang; Lee, Sanghun; Kim, Jung Hoon; Lim, Jung Ah; Kim, Tae Joon; Byun, Jung Ick; Jeong, Min Hee; Cha, Kwang Su; Choi, Jeong Woo; Kim, Kyung Hwan; Lee, Soon Tae; Jung, Keun Hwa; Park, Kyung Il; Chu, Kon; Kim, Manho; Lee, Sang Kun; Jung, Ki Young.

In: Sleep, Vol. 40, No. 6, 06.2017.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Altered functional connectivity in idiopathic rapid eye movement sleep behavior disorder

T2 - A resting-state EEG study

AU - Sunwoo, Jun Sang

AU - Lee, Sanghun

AU - Kim, Jung Hoon

AU - Lim, Jung Ah

AU - Kim, Tae Joon

AU - Byun, Jung Ick

AU - Jeong, Min Hee

AU - Cha, Kwang Su

AU - Choi, Jeong Woo

AU - Kim, Kyung Hwan

AU - Lee, Soon Tae

AU - Jung, Keun Hwa

AU - Park, Kyung Il

AU - Chu, Kon

AU - Kim, Manho

AU - Lee, Sang Kun

AU - Jung, Ki Young

PY - 2017/6

Y1 - 2017/6

N2 - Study Objectives: Idiopathic rapid eye movement sleep behavior disorder (iRBD) is considered as a prodromal stage of synucleinopathy. Although loss of functional connectivity is implicated in neurodegenerative diseases, network characteristics of electroencephalography (EEG) in iRBD are unknown. Therefore, we evaluated resting-state EEG functional connectivity to identify the brain network changes in patients with iRBD. Methods: We prospectively enrolled 20 patients with polysomnography-confirmed iRBD and 16 controls. Four patients with mild cognitive impairment were excluded from the analysis after cognitive function tests. EEG was recorded during relaxed wakefulness. We computed the weighted phase lag index as a measure of functional connectivity from EEG recordings. Results: All patients with iRBD (mean age 64.3 years; men, 68.8%) had no overt manifestations of neurodegenerative diseases such as Parkinsonism or dementia. The mean duration from symptom onset was 4.8 years. Overall connectivity strength did not differ between the two groups in all frequency bands. However, comparisons of each functional connection with the nonparametric permutation test demonstrated iRBD had decreased delta-band functional connectivity in the frontal regions. There were no significantly increased functional connections in all frequencies. The altered connections had a significant correlation with RBD questionnaire scores. Notably, delta-band weighted phase lag index between left frontal and central regions was correlated with verbal fluency performance (r = 0.486, p = .007). Conclusions: Resting-state brain network of iRBD was characterized by a loss of delta-band functional connectivity. Therefore, functional networks in iRBD are altered at the early phase of disease.

AB - Study Objectives: Idiopathic rapid eye movement sleep behavior disorder (iRBD) is considered as a prodromal stage of synucleinopathy. Although loss of functional connectivity is implicated in neurodegenerative diseases, network characteristics of electroencephalography (EEG) in iRBD are unknown. Therefore, we evaluated resting-state EEG functional connectivity to identify the brain network changes in patients with iRBD. Methods: We prospectively enrolled 20 patients with polysomnography-confirmed iRBD and 16 controls. Four patients with mild cognitive impairment were excluded from the analysis after cognitive function tests. EEG was recorded during relaxed wakefulness. We computed the weighted phase lag index as a measure of functional connectivity from EEG recordings. Results: All patients with iRBD (mean age 64.3 years; men, 68.8%) had no overt manifestations of neurodegenerative diseases such as Parkinsonism or dementia. The mean duration from symptom onset was 4.8 years. Overall connectivity strength did not differ between the two groups in all frequency bands. However, comparisons of each functional connection with the nonparametric permutation test demonstrated iRBD had decreased delta-band functional connectivity in the frontal regions. There were no significantly increased functional connections in all frequencies. The altered connections had a significant correlation with RBD questionnaire scores. Notably, delta-band weighted phase lag index between left frontal and central regions was correlated with verbal fluency performance (r = 0.486, p = .007). Conclusions: Resting-state brain network of iRBD was characterized by a loss of delta-band functional connectivity. Therefore, functional networks in iRBD are altered at the early phase of disease.

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