The Roux-en-Y gastric bypass (RYGB) is highly effective in the remission of obesity and associated diabetes. The mechanisms underlying obesity and type 2 diabetes mellitus remission after RYGB remain unclear. This study aimed to evaluate the changes in continuous dynamic FDG uptake patterns after RYGB and examine the correlation between glucose metabolism and its transporters in variable endocrine organs using 18F-fluoro-2-deoxyglucose positron emission tomography images. Increased glucose metabolism in specific organs, such as the small intestine and various fat tissues, is closely associated with improved glycemic control after RYGB. In Otsuka Long-Evans Tokushima Fatty rats fed with high-fat diets, RYGB operation increases intestine glucose transporter expression and various fat tissues’ glucose transporters, which are not affected by insulin. The fasting glucose decrement was significantly associated with RYGB, sustained weight loss, post-RYGB oral glucose tolerance test (OGTT) area under the curve (AUC), glucose transporter, or glycolytic enzymes in the small bowel and various fat tissues. High intestinal glucose metabolism and white adipose tissue-dependent glucose metabolism correlated with metabolic benefit after RYGB. These findings suggest that the newly developed glucose biodistribution accompanied by increased glucose transporters is a mechanism associated with the systemic effect of RYGB.
|Journal||Frontiers in Endocrinology|
|Publication status||Published - 2022 Jul 14|
Bibliographical noteFunding Information:
We would like to thank Byung Gon Kim and Jung-Hyun Ji, members of the laboratory animal research Centre of ABMRC at Yonsei University College of Medicine, for their technical support with animal experiments. We also thank the Editage (www. editage. co. kr) for English language editing.
This research was supported by a grant from the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, the Republic of Korea (grant number: HR18C0012).
Copyright © 2022 Oh, Kang, Wang, Nam, Lee, Park, Lee, Cho and Ku.
All Science Journal Classification (ASJC) codes
- Endocrinology, Diabetes and Metabolism