Altered hemispheric asymmetry and positive symptoms in schizophrenia: Equivalent current dipole of auditory mismatch negativity

Tak Youn, Hae Jeong Park, Jae-Jin Kim, Myung Sun Kim, Jun Soo Kwon

Research output: Contribution to journalArticle

83 Citations (Scopus)

Abstract

The abnormality of mismatch negativity (MMN) in schizophrenia is thought to be associated with perceptional disturbance and cognitive dysfunction. The purpose of the present study was to investigate the change of the normal functional hemispheric lateralization in schizophrenia by employing the equivalent current dipole (ECD) model of auditory MMN with individual MRI and high-density electroencephalography (EEG). The MMNs resulting from auditory stimuli with passive oddball paradigm in a group of schizophrenics (n=15), and also a group of age-, sex-, and handedness-matched normal controls, were recorded by 128 channel EEG. The location and power of ECD sources at the peak point were calculated. Individual 3-D brain magnetic resonance images (MRI) were used for realistic head modeling and for source localization. For both groups, the MMN source was determined to be located in the superior temporal gyrus (STG). However, the normal functional hemispheric asymmetry of ECD power was significantly altered in the schizophrenics (χ2 test=16.13, p<0.001). Left MMN ECD power and the asymmetry coefficient (AC) were negatively correlated with the positive scores from Positive and Negative Syndrome Scale (PANSS) (r=-0.673, p=0.008), especially with the hallucinatory behavior subscale (r=-0.677, p=0.008). These findings support the deficits in preattentive automatic processing of auditory stimuli, especially in the left hemisphere, and indicate the correlation between positive symptoms, especially auditory hallucination, and left temporal lobe dysfunction in schizophrenia.

Original languageEnglish
Pages (from-to)253-260
Number of pages8
JournalSchizophrenia Research
Volume59
Issue number2-3
DOIs
Publication statusPublished - 2003 Feb 1

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Schizophrenia
Temporal Lobe
Electroencephalography
Magnetic Resonance Spectroscopy
Functional Laterality
Hallucinations
Age Groups
Head
Brain
Power (Psychology)
Cognitive Dysfunction

All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health
  • Behavioral Neuroscience
  • Biological Psychiatry
  • Neurology
  • Psychology(all)

Cite this

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abstract = "The abnormality of mismatch negativity (MMN) in schizophrenia is thought to be associated with perceptional disturbance and cognitive dysfunction. The purpose of the present study was to investigate the change of the normal functional hemispheric lateralization in schizophrenia by employing the equivalent current dipole (ECD) model of auditory MMN with individual MRI and high-density electroencephalography (EEG). The MMNs resulting from auditory stimuli with passive oddball paradigm in a group of schizophrenics (n=15), and also a group of age-, sex-, and handedness-matched normal controls, were recorded by 128 channel EEG. The location and power of ECD sources at the peak point were calculated. Individual 3-D brain magnetic resonance images (MRI) were used for realistic head modeling and for source localization. For both groups, the MMN source was determined to be located in the superior temporal gyrus (STG). However, the normal functional hemispheric asymmetry of ECD power was significantly altered in the schizophrenics (χ2 test=16.13, p<0.001). Left MMN ECD power and the asymmetry coefficient (AC) were negatively correlated with the positive scores from Positive and Negative Syndrome Scale (PANSS) (r=-0.673, p=0.008), especially with the hallucinatory behavior subscale (r=-0.677, p=0.008). These findings support the deficits in preattentive automatic processing of auditory stimuli, especially in the left hemisphere, and indicate the correlation between positive symptoms, especially auditory hallucination, and left temporal lobe dysfunction in schizophrenia.",
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Altered hemispheric asymmetry and positive symptoms in schizophrenia : Equivalent current dipole of auditory mismatch negativity. / Youn, Tak; Park, Hae Jeong; Kim, Jae-Jin; Kim, Myung Sun; Kwon, Jun Soo.

In: Schizophrenia Research, Vol. 59, No. 2-3, 01.02.2003, p. 253-260.

Research output: Contribution to journalArticle

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