Altered neural basis of the reality processing and its relation to cognitive insight in schizophrenia

Jung Suk Lee, Ji Won Chun, Sang Hoon Lee, Eosu Kim, Seung Koo Lee, Jae Jin Kim

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

It has been reported that reality evaluation and recognition are impaired in patients with schizophrenia and these impairments are related to the severity of psychotic symptoms. The current study aimed to investigate the neural basis of impairments in reality evaluation and recognition and their relationships with cognitive insight in schizophrenia. During functional magnetic resonance imaging, 20 patients with schizophrenia and 20 healthy controls performed a set of reality evaluation and recognition tasks, in which subjects judged whether scenes in a series of drawings were real or unreal and whether they were familiar or novel. During reality evaluation, patients showed decreased activity in various regions including the inferior parietal lobule, retrosplenial cortex and parahippocampal gyrus, compared with controls. Particularly, parahippocampal gyrus activity was correlated with the severity of positive symptoms in patients. During recognition, patients also exhibited decreased activity in various regions, including the dorsolateral prefrontal cortex, inferior parietal lobule and posterior cingulate cortex. Particularly, inferior parietal lobule activity and posterior cingulate cortex activity were correlated with cognitive insight in patients. These findings provide evidence that neural impairments in reality evaluation and recognition are related to psychotic symptoms. Anomalous appraisal of context by dysfunctions in the context network may contribute to impairments in the reality processing in schizophrenia, and abnormal declarative memory processes may be involved in cognitive insight in patients with schizophrenia.

Original languageEnglish
Article numbere0120478
JournalPloS one
Volume10
Issue number3
DOIs
Publication statusPublished - 2015 Mar 20

Fingerprint

Schizophrenia
Parietal Lobe
Processing
signs and symptoms (animals and humans)
Parahippocampal Gyrus
cortex
Data storage equipment
Gyrus Cinguli
schizophrenia
Prefrontal Cortex
magnetic resonance imaging
Magnetic Resonance Imaging
Recognition (Psychology)

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

Cite this

Lee, Jung Suk ; Chun, Ji Won ; Lee, Sang Hoon ; Kim, Eosu ; Lee, Seung Koo ; Kim, Jae Jin. / Altered neural basis of the reality processing and its relation to cognitive insight in schizophrenia. In: PloS one. 2015 ; Vol. 10, No. 3.
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Altered neural basis of the reality processing and its relation to cognitive insight in schizophrenia. / Lee, Jung Suk; Chun, Ji Won; Lee, Sang Hoon; Kim, Eosu; Lee, Seung Koo; Kim, Jae Jin.

In: PloS one, Vol. 10, No. 3, e0120478, 20.03.2015.

Research output: Contribution to journalArticle

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