Altered secretory pattern of pancreatic enzymes and gastrointestinal hormones in streptozotocin-induced diabetic rats

Myung Jun Kim, Gyeong Ryul Ryu, Sae Young Yi, Do Sik Min, Duck Joo Rhie, Shin Hee Yoon, Sang June Hahn, Myung Suk Kim, Yang Hyeok Jo

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

This study was performed to investigate the pancreatic exocrine dysfunction in streptozotocin-induced diabetic rats. Changes in pancreatic enzymes secretion and in pancreatic enzymes content were observed. The output and the tissue content of amylase were significantly reduced in diabetic rats, while the output and the content of lipase were increased. Plasma secretin and cholecystokinin (CCK) concentrations of diabetic rats were significantly increased compared to those of normal rats. The altered pancreatic exocrine function was abolished by the exogenous insulin administration. The exogenous insulin also restored the increased plasma secretin and CCK concentrations. From the above results, it is suggested that, in streptozotocin-induced diabetic rats, anticoordinated changes in pancreatic enzymes secretion as well as pancreatic enzymes content are attributable to insulin deficiency and that the insulin deficiency is responsible for the increased plasma concentrations of both secretin and CCK. However, it is not clear whether the elevated plasma secretin and CCK concentrations played a direct role in changes of pancreatic exocrine function.

Original languageEnglish
Pages (from-to)311-317
Number of pages7
JournalKorean Journal of Physiology and Pharmacology
Volume6
Issue number6
Publication statusPublished - 2002 Dec 1

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Pancreatic Hormones
Gastrointestinal Hormones
Streptozocin
Secretin
Cholecystokinin
Insulin
Enzymes
Amylases
Lipase

All Science Journal Classification (ASJC) codes

  • Physiology
  • Pharmacology

Cite this

Kim, Myung Jun ; Ryu, Gyeong Ryul ; Yi, Sae Young ; Min, Do Sik ; Rhie, Duck Joo ; Yoon, Shin Hee ; Hahn, Sang June ; Kim, Myung Suk ; Jo, Yang Hyeok. / Altered secretory pattern of pancreatic enzymes and gastrointestinal hormones in streptozotocin-induced diabetic rats. In: Korean Journal of Physiology and Pharmacology. 2002 ; Vol. 6, No. 6. pp. 311-317.
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abstract = "This study was performed to investigate the pancreatic exocrine dysfunction in streptozotocin-induced diabetic rats. Changes in pancreatic enzymes secretion and in pancreatic enzymes content were observed. The output and the tissue content of amylase were significantly reduced in diabetic rats, while the output and the content of lipase were increased. Plasma secretin and cholecystokinin (CCK) concentrations of diabetic rats were significantly increased compared to those of normal rats. The altered pancreatic exocrine function was abolished by the exogenous insulin administration. The exogenous insulin also restored the increased plasma secretin and CCK concentrations. From the above results, it is suggested that, in streptozotocin-induced diabetic rats, anticoordinated changes in pancreatic enzymes secretion as well as pancreatic enzymes content are attributable to insulin deficiency and that the insulin deficiency is responsible for the increased plasma concentrations of both secretin and CCK. However, it is not clear whether the elevated plasma secretin and CCK concentrations played a direct role in changes of pancreatic exocrine function.",
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Altered secretory pattern of pancreatic enzymes and gastrointestinal hormones in streptozotocin-induced diabetic rats. / Kim, Myung Jun; Ryu, Gyeong Ryul; Yi, Sae Young; Min, Do Sik; Rhie, Duck Joo; Yoon, Shin Hee; Hahn, Sang June; Kim, Myung Suk; Jo, Yang Hyeok.

In: Korean Journal of Physiology and Pharmacology, Vol. 6, No. 6, 01.12.2002, p. 311-317.

Research output: Contribution to journalReview article

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T1 - Altered secretory pattern of pancreatic enzymes and gastrointestinal hormones in streptozotocin-induced diabetic rats

AU - Kim, Myung Jun

AU - Ryu, Gyeong Ryul

AU - Yi, Sae Young

AU - Min, Do Sik

AU - Rhie, Duck Joo

AU - Yoon, Shin Hee

AU - Hahn, Sang June

AU - Kim, Myung Suk

AU - Jo, Yang Hyeok

PY - 2002/12/1

Y1 - 2002/12/1

N2 - This study was performed to investigate the pancreatic exocrine dysfunction in streptozotocin-induced diabetic rats. Changes in pancreatic enzymes secretion and in pancreatic enzymes content were observed. The output and the tissue content of amylase were significantly reduced in diabetic rats, while the output and the content of lipase were increased. Plasma secretin and cholecystokinin (CCK) concentrations of diabetic rats were significantly increased compared to those of normal rats. The altered pancreatic exocrine function was abolished by the exogenous insulin administration. The exogenous insulin also restored the increased plasma secretin and CCK concentrations. From the above results, it is suggested that, in streptozotocin-induced diabetic rats, anticoordinated changes in pancreatic enzymes secretion as well as pancreatic enzymes content are attributable to insulin deficiency and that the insulin deficiency is responsible for the increased plasma concentrations of both secretin and CCK. However, it is not clear whether the elevated plasma secretin and CCK concentrations played a direct role in changes of pancreatic exocrine function.

AB - This study was performed to investigate the pancreatic exocrine dysfunction in streptozotocin-induced diabetic rats. Changes in pancreatic enzymes secretion and in pancreatic enzymes content were observed. The output and the tissue content of amylase were significantly reduced in diabetic rats, while the output and the content of lipase were increased. Plasma secretin and cholecystokinin (CCK) concentrations of diabetic rats were significantly increased compared to those of normal rats. The altered pancreatic exocrine function was abolished by the exogenous insulin administration. The exogenous insulin also restored the increased plasma secretin and CCK concentrations. From the above results, it is suggested that, in streptozotocin-induced diabetic rats, anticoordinated changes in pancreatic enzymes secretion as well as pancreatic enzymes content are attributable to insulin deficiency and that the insulin deficiency is responsible for the increased plasma concentrations of both secretin and CCK. However, it is not clear whether the elevated plasma secretin and CCK concentrations played a direct role in changes of pancreatic exocrine function.

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