Altered tooth morphogenesis after silencing the planar cell polarity core component, Vangl2

Zhaoming Wu, Don Jeevanie Epasinghe, Jinquan He, Liwen Li, David W. Green, Min Jung Lee, Han Sung Jung

Research output: Contribution to journalArticle

5 Citations (Scopus)


Vangl2, one of the core components of the planar cell polarity (PCP) pathway, has an important role in the regulation of morphogenesis in several tissues. Although the expression of Vangl2 has been detected in the developing tooth, its role in tooth morphogenesis is not known. In this study, we show that Vangl2 is expressed in the inner dental epithelium (IDE) and in the secondary enamel knots (SEKs) of bell stage tooth germs. Inhibition of Vangl2 expression by siRNA treatment in in vitro-cultured tooth germs resulted in retarded tooth germ growth with deregulated cell proliferation and apoptosis. After kidney transplantation of Vangl2 siRNA-treated tooth germs, teeth were observed to be small and malformed. We also show that Vangl2 is required to maintain the proper pattern of cell alignment in SEKs, which maybe important for the function of SEKs as signaling centers. These results suggest that Vangl2 plays an important role in the morphogenesis of teeth.

Original languageEnglish
Pages (from-to)617-621
Number of pages5
JournalCell and Tissue Research
Issue number3
Publication statusPublished - 2016 Dec 1

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Histology
  • Cell Biology

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