Alveolar ridge regeneration in two-wall-damaged extraction sockets of an in vivo experimental model

Hsu Kuo Tien, Won Ho Lee, Chang Sung Kim, Seong Ho Choi, Reinhard Gruber, Jung Seok Lee

Research output: Contribution to journalArticlepeer-review

Abstract

Aim: To determine the healing outcome following grafting with deproteinized porcine bone mineral (DPBM) with or without collagen membrane coverage in two-wall (both buccal and lingual)-damaged extraction sockets. Materials and methods: Distal roots of three mandibular premolars in six beagle dogs were extracted, and the whole buccal and lingual bony walls were surgically removed. Three treatment protocols were then applied according to the following group allocation: no graft (None), grafting DPBM (BG), and grafting DPBM with coverage by a collagen membrane (BG + M). Two observational periods (2 and 8 weeks) were used with the split-mouth design, and quantitative and qualitative analyses were performed by microcomputed tomography and histology. Results: The dimensions of the alveolar ridge at both grafted sites (BG and BG + M) remained similar to those of the pristine ridge in the histologic and radiographic analyses, whereas the ungrafted sites (None) collapsed both vertically and horizontally. Both grafting protocols produced substantial bony regeneration, but the addition of a covering membrane enhanced the proportion of mineralized tissue within the augmented area, and the BG + M group also showed a significantly larger area of regenerated ridge than the None group (p <.05). Conclusions: Bone grafting with collagen membrane can maintain the alveolar ridge dimensions with substantial bone regeneration in a two-wall-damaged extraction socket.

Original languageEnglish
Pages (from-to)971-979
Number of pages9
JournalClinical Oral Implants Research
Volume32
Issue number8
DOIs
Publication statusPublished - 2021 Aug

Bibliographical note

Funding Information:
The Korea Medical Device Development Fund grant funded by the Korea Government (the Ministry of Science and ICT, the Ministry of Trade, Industry and Energy, the Ministry of Health & Welfare, the Ministry of Food and Drug Safety) (KMDF_PR_20200901_0238)

Funding Information:
This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (Ministry of Science, ICT & Future Planning) (NRF-2019R1A2C4069942) and a grant of the Korea government (the Ministry of Science and ICT, the Ministry of Trade, Industry and Energy, the Ministry of Health & Welfare, the Ministry of Food and Drug Safety) (KMDF_PR_20200901_0238).

Publisher Copyright:
© 2021 The Authors. Clinical Oral Implants Research published by John Wiley & Sons Ltd.

All Science Journal Classification (ASJC) codes

  • Oral Surgery

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