Ambidextrous magnetic nanovectors for synchronous gene transfection and labeling of human MSCs

Jaemoon Yang, Eun Sook Lee, Min Young Noh, Seong Ho Koh, Eun Kyung Lim, A. Rum Yoo, Kwangyeol Lee, Jin Suck Suh, Seung Hyun Kim, Seungjoo Haam, Yong Min Huh

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

The synchronization of gene expression and cell trafficking in transfected stem cells is crucial for augmentation of stem cell functions (differentiation and neurotropic factor secretion) and real time in vivo monitoring. We report a magnetic nanoparticle-based gene delivery system that can ensure simultaneous gene delivery and in vivo cell trafficking by high resolution MR imaging. The polar aprotic solvent soluble MnFe 2O 4 nanoparticles were enveloped using cationic polymers (branched polyethyleneimine, PEI) by the solvent shifting method for a gene loading. Using our magnetic nanovector system (PEI-coated MnFe 2O 4 nanoparticles), thus, we synchronized stem cell migration and its gene expression in a rat stroke model.

Original languageEnglish
Pages (from-to)6174-6182
Number of pages9
JournalBiomaterials
Volume32
Issue number26
DOIs
Publication statusPublished - 2011 Sep 1

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Ceramics and Composites
  • Biophysics
  • Biomaterials
  • Mechanics of Materials

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