Ambient carbon monoxide exposure and elevated risk of mortality in the glioblastoma patients: A double-cohort retrospective observational study

Seon Jin Yoon, Juhwan Noh, Hye Young Son, Ju Hyung Moon, Eui Hyun Kim, Sahng Wook Park, Se Hoon Kim, Jong Hee Chang, Yong Min Huh, Seok Gu Kang

Research output: Contribution to journalArticlepeer-review

Abstract

An increasing number of studies indicate air pollutants infiltrate into the brain. We aimed to find the association of cumulative air pollution exposure in the main body of primary brain tumor: glioblastoma (GBM). In this double-cohort, retrospective analysis study with a protocol, we compared the health effect of air pollution on the GBM patients from the SEER (Surveillance, Epidemiology, and End Results Program) in 27 U.S. counties from 10 states and GBM patients of Severance cohort of Korea. From 2000 to 2015, 10621 GBM patients of the SEER were individually evaluated for the cumulative average exposure for each pollutant, and 9444 (88.9%) mortality events were reported. From 2011 to 2018, 398 GBM patients of the Severance with the same protocol showed 259 (65.1%) mortality events. The multi-pollutant models show that the association level of risk with CO is increased in the SEER (HR 1.252; 95% CI 1.141-1.373) with an increasing linear trend of relative death rate in the spline curve. The Severance GBM data showed such a statistically significant result of the health impact of CO on GBM patients. The overall survival gain of the less exposure group against CO was 2 and 3 months in the two cohorts. Perioperative exposure to CO may increase the risk of shorter survival of GBM patients of the SEER and the Severance cohort.

Original languageEnglish
Pages (from-to)9018-9026
Number of pages9
JournalCancer medicine
Volume9
Issue number23
DOIs
Publication statusPublished - 2020 Dec

Bibliographical note

Funding Information:
This work was supported by the grants to S‐JY from the Health Fellowship Foundation of Yuhan Foundation (2019), and supported by the grants to S‐GK from the Korean Health Technology R&D Project, Ministry of Health & Welfare, Republic of Korea (HI17C2586), the NRF grant funded by the Korea government (MEST) (NRF‐2019R1A2C3004155), and the NRF grant funded by the MSIP: Ministry of Science, ICT and Future Planning, Republic of Korea (NRF‐2017M2A2A7A01071036), and by the grants to Y‐MH from the NRF funded by the MSIP (NRF‐2017M3A9G5083322, NRF‐2015M3A9D7029878).

Publisher Copyright:
© 2020 The Authors. Cancer Medicine published by John Wiley & Sons Ltd

All Science Journal Classification (ASJC) codes

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

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