Amelioration of Alzheimer's disease by neuroprotective effect of sulforaphane in animal model

Hyunjin Vincent Kim, Hye Yun Kim, Hanna Y. Ehrlich, Seon Young Choi, Dong Jin Kim, YoungSoo Kim

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

Pathophysiological evidences of AD have indicated that aggregation of Aβ is one of the principal causes of neuronal dysfunction, largely by way of inducing oxidative stresses such as free radical formation. We hypothesized that the known antioxidative attribute of SFN could be harnessed in Alzheimer's treatment. SFN is an indirect, potent antioxidant derived from broccoli that has previously been found to stimulate the Nrf2-ARE pathway and facilitate several other cytoprotective mechanisms. In this study, administration of SFN ameliorated cognitive function of Aβ-induced AD acute mouse models in Y-maze and passive avoidance behavior tests. Interestingly, we found that the therapeutic effect of SFN did not involve inhibition of Aβ aggregation. While the exact mechanism of interaction of SFN in AD has not yet been ascertained, our results suggest that SFN can aid in cognitive impairment and may protect the brain from amyloidogenic damages. Abbreviations: Aβ, amyloid-β; AD, Alzheimer's disease; PBS, phosphate buffered saline; DMSO, dimethyl sulfoxide; ROS, reactive oxygen species; SFN, sulforaphane; DMEM, Dulbecco's modified eagle medium; FBS, fetal bovine serum; ICR, imprinting control region; MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; DW, deionized water; ThT, thioflavin T; PA, passive avoidance; ARE, antioxidant response element.

Original languageEnglish
Pages (from-to)7-12
Number of pages6
JournalAmyloid
Volume20
Issue number1
DOIs
Publication statusPublished - 2013 Mar 1

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Neuroprotective Agents
Dimethyl Sulfoxide
Alzheimer Disease
Animal Models
Antioxidant Response Elements
Avoidance Learning
Eagles
Brassica
Therapeutic Uses
Amyloid
Cognition
Free Radicals
Reactive Oxygen Species
Oxidative Stress
Antioxidants
Phosphates
Water
Brain
Serum
sulforafan

All Science Journal Classification (ASJC) codes

  • Internal Medicine

Cite this

Kim, Hyunjin Vincent ; Kim, Hye Yun ; Ehrlich, Hanna Y. ; Choi, Seon Young ; Kim, Dong Jin ; Kim, YoungSoo. / Amelioration of Alzheimer's disease by neuroprotective effect of sulforaphane in animal model. In: Amyloid. 2013 ; Vol. 20, No. 1. pp. 7-12.
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Amelioration of Alzheimer's disease by neuroprotective effect of sulforaphane in animal model. / Kim, Hyunjin Vincent; Kim, Hye Yun; Ehrlich, Hanna Y.; Choi, Seon Young; Kim, Dong Jin; Kim, YoungSoo.

In: Amyloid, Vol. 20, No. 1, 01.03.2013, p. 7-12.

Research output: Contribution to journalArticle

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