Aminoacyl-tRNA synthetases and amino acid signaling

Ya Chun Yu, Jung Min Han, Sunghoon Kim

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)

Abstract

Aminoacyl-tRNA synthetases (ARSs) are a family of evolutionarily conserved housekeeping enzymes used for protein synthesis that have pivotal roles in the ligation of tRNA with their cognate amino acids. Recent advances in the structural and functional studies of ARSs have revealed many previously unknown biological functions beyond the classical catalytic roles. Sensing the sufficiency of intracellular nutrients such as amino acids, ATP, and fatty acids is a crucial aspect for every living organism, and it is closely connected to the regulation of diverse cellular physiologies. Notably, among ARSs, leucyl-tRNA synthetase 1 (LARS1) has been identified to perform specifically as a leucine sensor upstream of the amino acid-sensing pathway and thus participates in the coordinated control of protein synthesis and autophagy for cell growth. In addition to LARS1, other types of ARSs are also likely involved in the sensing and signaling of their cognate amino acids inside cells. Collectively, this review focuses on the mechanisms of ARSs interacting within amino acid signaling and proposes the possible role of ARSs as general intracellular amino acid sensors.

Original languageEnglish
Article number118889
JournalBiochimica et Biophysica Acta - Molecular Cell Research
Volume1868
Issue number1
DOIs
Publication statusPublished - 2021 Jan

Bibliographical note

Funding Information:
This work was supported by the Basic Science Research Program through the National Research Foundation (NRF) of Korea funded by the Ministry of Education [ 2018R1A6A1A03023718 ] and the NRF grant funded by the Korea government ( MSIT ) [ 2020R1A2C209958611 ] and by the Bio & Medical Technology Development Program of the NRF funded by the Ministry of Science & ICT [ 2020M3E5E2040282 ].

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cell Biology

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