Aminoacyl-tRNA synthetases and tumorigenesis: More than housekeeping

Sunghoon Kim, Sungyong You, Daehee Hwang

Research output: Contribution to journalArticlepeer-review

186 Citations (Scopus)

Abstract

Over the past decade, the identification of cancer-associated factors has been a subject of primary interest not only for understanding the basic mechanisms of tumorigenesis but also for discovering the associated therapeutic targets. However, aminoacyl-tRNA synthetases (ARSs) have been overlooked, mostly because many assumed that they were simply 'housekeepers' that were involved in protein synthesis. Mammalian ARSs have evolved many additional domains that are not necessarily linked to their catalytic activities. With these domains, they interact with diverse regulatory factors. In addition, the expression of some ARSs is dynamically changed depending on various cellular types and stresses. This Analysis article addresses the potential pathophysiological implications of ARSs in tumorigenesis.

Original languageEnglish
Pages (from-to)708-718
Number of pages11
JournalNature Reviews Cancer
Volume11
Issue number10
DOIs
Publication statusPublished - 2011 Oct

Bibliographical note

Funding Information:
This work was supported by the National Research Foundation of Korea Grant funded by the Korean Government (NRF-2008-359-C00024), the Global Frontier Project grant (NRF-M1AXA002-2010-0029785) and by [R31-2008-000-10103-0] and [R31-2008-000-10105-0] from the World Class University project of the Ministry of Education, Science and Technology.

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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