Abstract
The synthesis of a novel series of aminostyrylbenzofuran derivatives 1a-w and their inhibitory activities for Aβ fibril formation were described. All the synthesized compounds were evaluated by thioflavin T (ThT) assay and displayed potent inhibitory activities for Aβ fibril formation. Among them, compounds 1i and 1q exhibited excellent inhibitory activities (IC50 = 0.07 and 0.08 μM, respectively) than those of Curcumin (IC50 = 0.80 μM) and IMSB (IC50 = 8.00 μM) as reference compounds. Both compounds were selected as promising candidates for further biological evaluation.
| Original language | English |
|---|---|
| Pages (from-to) | 5591-5593 |
| Number of pages | 3 |
| Journal | Bioorganic and Medicinal Chemistry Letters |
| Volume | 18 |
| Issue number | 20 |
| DOIs | |
| Publication status | Published - 2008 Oct 15 |
Fingerprint
All Science Journal Classification (ASJC) codes
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Pharmaceutical Science
- Drug Discovery
- Clinical Biochemistry
- Organic Chemistry
Cite this
}
Aminostyrylbenzofuran derivatives as potent inhibitors for Aβ fibril formation. / Byun, Ji Hun; Kim, Hye Yun; Kim, Young Soo; Mook-Jung, Inhee; Kim, Dong Jin; Lee, Won Koo; Yoo, Kyung Ho.
In: Bioorganic and Medicinal Chemistry Letters, Vol. 18, No. 20, 15.10.2008, p. 5591-5593.Research output: Contribution to journal › Article
TY - JOUR
T1 - Aminostyrylbenzofuran derivatives as potent inhibitors for Aβ fibril formation
AU - Byun, Ji Hun
AU - Kim, Hye Yun
AU - Kim, Young Soo
AU - Mook-Jung, Inhee
AU - Kim, Dong Jin
AU - Lee, Won Koo
AU - Yoo, Kyung Ho
PY - 2008/10/15
Y1 - 2008/10/15
N2 - The synthesis of a novel series of aminostyrylbenzofuran derivatives 1a-w and their inhibitory activities for Aβ fibril formation were described. All the synthesized compounds were evaluated by thioflavin T (ThT) assay and displayed potent inhibitory activities for Aβ fibril formation. Among them, compounds 1i and 1q exhibited excellent inhibitory activities (IC50 = 0.07 and 0.08 μM, respectively) than those of Curcumin (IC50 = 0.80 μM) and IMSB (IC50 = 8.00 μM) as reference compounds. Both compounds were selected as promising candidates for further biological evaluation.
AB - The synthesis of a novel series of aminostyrylbenzofuran derivatives 1a-w and their inhibitory activities for Aβ fibril formation were described. All the synthesized compounds were evaluated by thioflavin T (ThT) assay and displayed potent inhibitory activities for Aβ fibril formation. Among them, compounds 1i and 1q exhibited excellent inhibitory activities (IC50 = 0.07 and 0.08 μM, respectively) than those of Curcumin (IC50 = 0.80 μM) and IMSB (IC50 = 8.00 μM) as reference compounds. Both compounds were selected as promising candidates for further biological evaluation.
UR - http://www.scopus.com/inward/record.url?scp=53349147027&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=53349147027&partnerID=8YFLogxK
U2 - 10.1016/j.bmcl.2008.08.111
DO - 10.1016/j.bmcl.2008.08.111
M3 - Article
C2 - 18793854
AN - SCOPUS:53349147027
VL - 18
SP - 5591
EP - 5593
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
SN - 0960-894X
IS - 20
ER -