Abstract
The synthesis of a novel series of aminostyrylbenzofuran derivatives 1a-w and their inhibitory activities for Aβ fibril formation were described. All the synthesized compounds were evaluated by thioflavin T (ThT) assay and displayed potent inhibitory activities for Aβ fibril formation. Among them, compounds 1i and 1q exhibited excellent inhibitory activities (IC50 = 0.07 and 0.08 μM, respectively) than those of Curcumin (IC50 = 0.80 μM) and IMSB (IC50 = 8.00 μM) as reference compounds. Both compounds were selected as promising candidates for further biological evaluation.
| Original language | English |
|---|---|
| Pages (from-to) | 5591-5593 |
| Number of pages | 3 |
| Journal | Bioorganic and Medicinal Chemistry Letters |
| Volume | 18 |
| Issue number | 20 |
| DOIs | |
| Publication status | Published - 2008 Oct 15 |
All Science Journal Classification (ASJC) codes
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Pharmaceutical Science
- Drug Discovery
- Clinical Biochemistry
- Organic Chemistry
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Byun, J. H., Kim, H. Y., Kim, Y. S., Mook-Jung, I., Kim, D. J., Lee, W. K., & Yoo, K. H. (2008). Aminostyrylbenzofuran derivatives as potent inhibitors for Aβ fibril formation. Bioorganic and Medicinal Chemistry Letters, 18(20), 5591-5593. https://doi.org/10.1016/j.bmcl.2008.08.111