Aminostyrylbenzofuran derivatives as potent inhibitors for Aβ fibril formation

Ji Hun Byun, Hye Yun Kim, Young Soo Kim, Inhee Mook-Jung, Dong Jin Kim, Won Koo Lee, Kyung Ho Yoo

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

The synthesis of a novel series of aminostyrylbenzofuran derivatives 1a-w and their inhibitory activities for Aβ fibril formation were described. All the synthesized compounds were evaluated by thioflavin T (ThT) assay and displayed potent inhibitory activities for Aβ fibril formation. Among them, compounds 1i and 1q exhibited excellent inhibitory activities (IC50 = 0.07 and 0.08 μM, respectively) than those of Curcumin (IC50 = 0.80 μM) and IMSB (IC50 = 8.00 μM) as reference compounds. Both compounds were selected as promising candidates for further biological evaluation.

Original languageEnglish
Pages (from-to)5591-5593
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume18
Issue number20
DOIs
Publication statusPublished - 2008 Oct 15

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Curcumin
Inhibitory Concentration 50
Assays
Derivatives
thioflavin T

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

Byun, Ji Hun ; Kim, Hye Yun ; Kim, Young Soo ; Mook-Jung, Inhee ; Kim, Dong Jin ; Lee, Won Koo ; Yoo, Kyung Ho. / Aminostyrylbenzofuran derivatives as potent inhibitors for Aβ fibril formation. In: Bioorganic and Medicinal Chemistry Letters. 2008 ; Vol. 18, No. 20. pp. 5591-5593.
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Aminostyrylbenzofuran derivatives as potent inhibitors for Aβ fibril formation. / Byun, Ji Hun; Kim, Hye Yun; Kim, Young Soo; Mook-Jung, Inhee; Kim, Dong Jin; Lee, Won Koo; Yoo, Kyung Ho.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 18, No. 20, 15.10.2008, p. 5591-5593.

Research output: Contribution to journalArticle

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