Aminostyrylbenzofuran derivatives as potent inhibitors for Aβ fibril formation

Ji Hun Byun, Hye Yun Kim, Young Soo Kim, Inhee Mook-Jung, Dong Jin Kim, Won Koo Lee, Kyung Ho Yoo

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

The synthesis of a novel series of aminostyrylbenzofuran derivatives 1a-w and their inhibitory activities for Aβ fibril formation were described. All the synthesized compounds were evaluated by thioflavin T (ThT) assay and displayed potent inhibitory activities for Aβ fibril formation. Among them, compounds 1i and 1q exhibited excellent inhibitory activities (IC50 = 0.07 and 0.08 μM, respectively) than those of Curcumin (IC50 = 0.80 μM) and IMSB (IC50 = 8.00 μM) as reference compounds. Both compounds were selected as promising candidates for further biological evaluation.

Original languageEnglish
Pages (from-to)5591-5593
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume18
Issue number20
DOIs
Publication statusPublished - 2008 Oct 15

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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