Amorolfine nail lacquer 5% once weekly in onychomycosis of fingers and/or toes

H. C. Eun, M. H. Lee, S. N. Kim, H. J. Yoo, K. S. Kwon, SooChan Kim, J. S. Lee, B. S. Kim, B. S. Chung, S. H. Chang, C. W. Park, K. J. Kim, J. H. Lee

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: Amorolfine is a new topical antifungal drug of the morpholine class which has broad spectrum fungicidal activity. Amorolfine nail lacquer 5% is a transungual delivery system which can penetrate well through the nail plate to the infected keratin and remain there for a prolonged period. Objective: The aim of this study is to assess the efficacy and tolerability of 5% amerolfine nail lacquer given once weekly to the patients with onychomycosis. Methods: 29 patients with onychomycosis affecting not more than 80% of the surface of nail were treated once weekly for up to 9 months with amorolfine nail lacquer 5%. Clinical and mycological examination were performed before treatment and 3, 6, 9 months after start of treatment. Final evaluation was done 3 months after the end of treatment. Results: Average affected area (%) and average score of clinical signs - thickening, splitting, discoloration - were significantly decreased 3 months after start of treatment. Mycological cure rate was continuously increased according to the treatment duration reaching 75.9% at 3 months after treatment. Overall efficacy assessed by the investgators were cure in 31.0% and improvement in 41.4%. Tolerability, mode and frequency of treatment, and formulation were evaluated as good or excellent by most of the patients. No systemic or local side effect was observed. Conclusion: Amorolfine nail lacquer 5% used once weekly up to 9 months was relatively effective and safe for the treatment of onychomycosis.

Original languageEnglish
Pages (from-to)314-321
Number of pages8
JournalKorean Journal of Dermatology
Volume33
Issue number2
Publication statusPublished - 1995 Jan 1

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Lacquer
Onychomycosis
Toes
Nails
Fingers
Therapeutics
amorolfine
Keratins

All Science Journal Classification (ASJC) codes

  • Dermatology

Cite this

Eun, H. C., Lee, M. H., Kim, S. N., Yoo, H. J., Kwon, K. S., Kim, S., ... Lee, J. H. (1995). Amorolfine nail lacquer 5% once weekly in onychomycosis of fingers and/or toes. Korean Journal of Dermatology, 33(2), 314-321.
Eun, H. C. ; Lee, M. H. ; Kim, S. N. ; Yoo, H. J. ; Kwon, K. S. ; Kim, SooChan ; Lee, J. S. ; Kim, B. S. ; Chung, B. S. ; Chang, S. H. ; Park, C. W. ; Kim, K. J. ; Lee, J. H. / Amorolfine nail lacquer 5% once weekly in onychomycosis of fingers and/or toes. In: Korean Journal of Dermatology. 1995 ; Vol. 33, No. 2. pp. 314-321.
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title = "Amorolfine nail lacquer 5{\%} once weekly in onychomycosis of fingers and/or toes",
abstract = "Background: Amorolfine is a new topical antifungal drug of the morpholine class which has broad spectrum fungicidal activity. Amorolfine nail lacquer 5{\%} is a transungual delivery system which can penetrate well through the nail plate to the infected keratin and remain there for a prolonged period. Objective: The aim of this study is to assess the efficacy and tolerability of 5{\%} amerolfine nail lacquer given once weekly to the patients with onychomycosis. Methods: 29 patients with onychomycosis affecting not more than 80{\%} of the surface of nail were treated once weekly for up to 9 months with amorolfine nail lacquer 5{\%}. Clinical and mycological examination were performed before treatment and 3, 6, 9 months after start of treatment. Final evaluation was done 3 months after the end of treatment. Results: Average affected area ({\%}) and average score of clinical signs - thickening, splitting, discoloration - were significantly decreased 3 months after start of treatment. Mycological cure rate was continuously increased according to the treatment duration reaching 75.9{\%} at 3 months after treatment. Overall efficacy assessed by the investgators were cure in 31.0{\%} and improvement in 41.4{\%}. Tolerability, mode and frequency of treatment, and formulation were evaluated as good or excellent by most of the patients. No systemic or local side effect was observed. Conclusion: Amorolfine nail lacquer 5{\%} used once weekly up to 9 months was relatively effective and safe for the treatment of onychomycosis.",
author = "Eun, {H. C.} and Lee, {M. H.} and Kim, {S. N.} and Yoo, {H. J.} and Kwon, {K. S.} and SooChan Kim and Lee, {J. S.} and Kim, {B. S.} and Chung, {B. S.} and Chang, {S. H.} and Park, {C. W.} and Kim, {K. J.} and Lee, {J. H.}",
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Eun, HC, Lee, MH, Kim, SN, Yoo, HJ, Kwon, KS, Kim, S, Lee, JS, Kim, BS, Chung, BS, Chang, SH, Park, CW, Kim, KJ & Lee, JH 1995, 'Amorolfine nail lacquer 5% once weekly in onychomycosis of fingers and/or toes', Korean Journal of Dermatology, vol. 33, no. 2, pp. 314-321.

Amorolfine nail lacquer 5% once weekly in onychomycosis of fingers and/or toes. / Eun, H. C.; Lee, M. H.; Kim, S. N.; Yoo, H. J.; Kwon, K. S.; Kim, SooChan; Lee, J. S.; Kim, B. S.; Chung, B. S.; Chang, S. H.; Park, C. W.; Kim, K. J.; Lee, J. H.

In: Korean Journal of Dermatology, Vol. 33, No. 2, 01.01.1995, p. 314-321.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Amorolfine nail lacquer 5% once weekly in onychomycosis of fingers and/or toes

AU - Eun, H. C.

AU - Lee, M. H.

AU - Kim, S. N.

AU - Yoo, H. J.

AU - Kwon, K. S.

AU - Kim, SooChan

AU - Lee, J. S.

AU - Kim, B. S.

AU - Chung, B. S.

AU - Chang, S. H.

AU - Park, C. W.

AU - Kim, K. J.

AU - Lee, J. H.

PY - 1995/1/1

Y1 - 1995/1/1

N2 - Background: Amorolfine is a new topical antifungal drug of the morpholine class which has broad spectrum fungicidal activity. Amorolfine nail lacquer 5% is a transungual delivery system which can penetrate well through the nail plate to the infected keratin and remain there for a prolonged period. Objective: The aim of this study is to assess the efficacy and tolerability of 5% amerolfine nail lacquer given once weekly to the patients with onychomycosis. Methods: 29 patients with onychomycosis affecting not more than 80% of the surface of nail were treated once weekly for up to 9 months with amorolfine nail lacquer 5%. Clinical and mycological examination were performed before treatment and 3, 6, 9 months after start of treatment. Final evaluation was done 3 months after the end of treatment. Results: Average affected area (%) and average score of clinical signs - thickening, splitting, discoloration - were significantly decreased 3 months after start of treatment. Mycological cure rate was continuously increased according to the treatment duration reaching 75.9% at 3 months after treatment. Overall efficacy assessed by the investgators were cure in 31.0% and improvement in 41.4%. Tolerability, mode and frequency of treatment, and formulation were evaluated as good or excellent by most of the patients. No systemic or local side effect was observed. Conclusion: Amorolfine nail lacquer 5% used once weekly up to 9 months was relatively effective and safe for the treatment of onychomycosis.

AB - Background: Amorolfine is a new topical antifungal drug of the morpholine class which has broad spectrum fungicidal activity. Amorolfine nail lacquer 5% is a transungual delivery system which can penetrate well through the nail plate to the infected keratin and remain there for a prolonged period. Objective: The aim of this study is to assess the efficacy and tolerability of 5% amerolfine nail lacquer given once weekly to the patients with onychomycosis. Methods: 29 patients with onychomycosis affecting not more than 80% of the surface of nail were treated once weekly for up to 9 months with amorolfine nail lacquer 5%. Clinical and mycological examination were performed before treatment and 3, 6, 9 months after start of treatment. Final evaluation was done 3 months after the end of treatment. Results: Average affected area (%) and average score of clinical signs - thickening, splitting, discoloration - were significantly decreased 3 months after start of treatment. Mycological cure rate was continuously increased according to the treatment duration reaching 75.9% at 3 months after treatment. Overall efficacy assessed by the investgators were cure in 31.0% and improvement in 41.4%. Tolerability, mode and frequency of treatment, and formulation were evaluated as good or excellent by most of the patients. No systemic or local side effect was observed. Conclusion: Amorolfine nail lacquer 5% used once weekly up to 9 months was relatively effective and safe for the treatment of onychomycosis.

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Eun HC, Lee MH, Kim SN, Yoo HJ, Kwon KS, Kim S et al. Amorolfine nail lacquer 5% once weekly in onychomycosis of fingers and/or toes. Korean Journal of Dermatology. 1995 Jan 1;33(2):314-321.