Abstract
We developed new calcium phosphate bone substitute material, amorphous calcium polyphosphate. The new material is synthesized by a cement-like slif-setting reaction with calcium phosphate glass, basic materials and water. In this study, we prepared with CPG, Na2CO3 and NaOH solution. When they are mixed together, amorphous phase was precipitated. The precipitated amorphous phase consisted of polyphosphate chains condensed with Na ions released from Na2CO3 and NaOH. When the amorphous calcium polyphosphate dissolves, inorganic polyphosphates are released into the medium. The inorganic polyphosphates as the dissolution product inducted the calcification of the osteoblast cells. Therefore, in animal test, the new bone formation in rat calvarial defects treated with the new material was significantly higher than sham-surgery control group, especially in the initial stage. The amorphous calcium polyphosphate was biocompatible and bioresorbable and promoted the new bone formation.
| Original language | English |
|---|---|
| Pages (from-to) | 209-212 |
| Number of pages | 4 |
| Journal | Key Engineering Materials |
| Volume | 396-398 |
| DOIs | |
| Publication status | Published - 2009 Feb 2 |
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All Science Journal Classification (ASJC) codes
- Materials Science(all)
- Mechanics of Materials
- Mechanical Engineering
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Amorphous calcium polyphosphate bone regenerative materials based on calcium phosphate glass. / Lee, Byung Hyun; Kim, Min Chul; Choi, Seong Ho; Lee, Young Keun.
In: Key Engineering Materials, Vol. 396-398, 02.02.2009, p. 209-212.Research output: Contribution to journal › Article
TY - JOUR
T1 - Amorphous calcium polyphosphate bone regenerative materials based on calcium phosphate glass
AU - Lee, Byung Hyun
AU - Kim, Min Chul
AU - Choi, Seong Ho
AU - Lee, Young Keun
PY - 2009/2/2
Y1 - 2009/2/2
N2 - We developed new calcium phosphate bone substitute material, amorphous calcium polyphosphate. The new material is synthesized by a cement-like slif-setting reaction with calcium phosphate glass, basic materials and water. In this study, we prepared with CPG, Na2CO3 and NaOH solution. When they are mixed together, amorphous phase was precipitated. The precipitated amorphous phase consisted of polyphosphate chains condensed with Na ions released from Na2CO3 and NaOH. When the amorphous calcium polyphosphate dissolves, inorganic polyphosphates are released into the medium. The inorganic polyphosphates as the dissolution product inducted the calcification of the osteoblast cells. Therefore, in animal test, the new bone formation in rat calvarial defects treated with the new material was significantly higher than sham-surgery control group, especially in the initial stage. The amorphous calcium polyphosphate was biocompatible and bioresorbable and promoted the new bone formation.
AB - We developed new calcium phosphate bone substitute material, amorphous calcium polyphosphate. The new material is synthesized by a cement-like slif-setting reaction with calcium phosphate glass, basic materials and water. In this study, we prepared with CPG, Na2CO3 and NaOH solution. When they are mixed together, amorphous phase was precipitated. The precipitated amorphous phase consisted of polyphosphate chains condensed with Na ions released from Na2CO3 and NaOH. When the amorphous calcium polyphosphate dissolves, inorganic polyphosphates are released into the medium. The inorganic polyphosphates as the dissolution product inducted the calcification of the osteoblast cells. Therefore, in animal test, the new bone formation in rat calvarial defects treated with the new material was significantly higher than sham-surgery control group, especially in the initial stage. The amorphous calcium polyphosphate was biocompatible and bioresorbable and promoted the new bone formation.
UR - http://www.scopus.com/inward/record.url?scp=58849092455&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=58849092455&partnerID=8YFLogxK
U2 - 10.4028/0-87849-353-0.209
DO - 10.4028/0-87849-353-0.209
M3 - Article
AN - SCOPUS:58849092455
VL - 396-398
SP - 209
EP - 212
JO - Key Engineering Materials
JF - Key Engineering Materials
SN - 1013-9826
ER -