Amplitude modulation-based electrical stimulation for encoding multipixel spatiotemporal visual information in retinal neural activities

Sang Baek Ryu, Jeong Woo Choi, Kun No Ahn, Yong Sook Goo, Kyung Hwan Kim

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Retinal implants have been developed as a promising way to restore partial vision for the blind. The observation and analysis of neural activities can offer valuable insights for successful prosthetic electrical stimulation. Retinal ganglion cell (RGC) activities have been investigated to provide knowledge on the requirements for electrical stimulation, such as threshold current and the effect of stimulation waveforms. To develop a detailed 'stimulation strategy' for faithful delivery of spatiotemporal visual information to the brain, it is essential to examine both the temporal and spatial characteristics of RGC responses, whereas previous studies were mainly focused on one or the other. In this study, we investigate whether the spatiotemporal visual information can be decoded from the RGC network activity evoked by patterned electrical stimulation. Along with a thorough characterization of spatial spreading of stimulation current and temporal information encoding, we demonstrated that multipixel spatiotemporal visual information can be accurately decoded from the population activities of RGCs stimulated by amplitudemodulated pulse trains. We also found that the details of stimulation, such as pulse amplitude range and pulse rate, were crucial for accurate decoding. Overall, the results suggest that useful visual function may be restored by amplitude modulation-based retinal stimulation.

Original languageEnglish
Pages (from-to)900-907
Number of pages8
JournalJournal of Korean medical science
Volume32
Issue number6
DOIs
Publication statusPublished - 2017 Jan 1

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Retinal Ganglion Cells
Electric Stimulation
Heart Rate
Observation
Brain
Population

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

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abstract = "Retinal implants have been developed as a promising way to restore partial vision for the blind. The observation and analysis of neural activities can offer valuable insights for successful prosthetic electrical stimulation. Retinal ganglion cell (RGC) activities have been investigated to provide knowledge on the requirements for electrical stimulation, such as threshold current and the effect of stimulation waveforms. To develop a detailed 'stimulation strategy' for faithful delivery of spatiotemporal visual information to the brain, it is essential to examine both the temporal and spatial characteristics of RGC responses, whereas previous studies were mainly focused on one or the other. In this study, we investigate whether the spatiotemporal visual information can be decoded from the RGC network activity evoked by patterned electrical stimulation. Along with a thorough characterization of spatial spreading of stimulation current and temporal information encoding, we demonstrated that multipixel spatiotemporal visual information can be accurately decoded from the population activities of RGCs stimulated by amplitudemodulated pulse trains. We also found that the details of stimulation, such as pulse amplitude range and pulse rate, were crucial for accurate decoding. Overall, the results suggest that useful visual function may be restored by amplitude modulation-based retinal stimulation.",
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Amplitude modulation-based electrical stimulation for encoding multipixel spatiotemporal visual information in retinal neural activities. / Ryu, Sang Baek; Choi, Jeong Woo; Ahn, Kun No; Goo, Yong Sook; Kim, Kyung Hwan.

In: Journal of Korean medical science, Vol. 32, No. 6, 01.01.2017, p. 900-907.

Research output: Contribution to journalArticle

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