Amyloid-β-related and unrelated cortical thinning in dementia with Lewy bodies

Young gun Lee, Seun Jeon, Han Soo Yoo, Seok Jong Chung, Seung Koo Lee, Phil Hyu Lee, Young Ho Sohn, Mijin Yun, Alan C. Evans, Byoung Seok Ye

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Coexisting Alzheimer's disease (AD) pathology is common in patients with dementia with Lewy bodies (DLB). To evaluate the cortical thinning in patients with DLB considering the effect of amyloid-β (Aβ), we compared the regional cortical thickness between control subjects and patients with DLB with abnormal dopamine transporter imaging. Seventeen (43.6%) of 39 patients with DLB and no control subjects had significant Aβ deposition on 18F-florbetaben positron emission tomography. Compared to control (n = 15), Aβ-negative DLB group (n = 21) had cortical thinning in the bilateral insula, entorhinal, basal frontal, and occipito-parietal cortices. Compared to Aβ-negative DLB, Aβ-positive DLB group (n = 15) had a lower cortical thickness in the AD-prone brain regions in addition to the bilateral occipital, basal frontal, and somatomotor cortices. After controlling for the amount of Aβ deposition, DLB group had cortical thinning in the same regions affected in the Aβ-negative DLB group. In summary, patients with DLB had an Aβ-independent cortical thinning, while Aβ was associated with additional cortical thinning in the AD-prone brain regions and the aggravation of DLB-specific cortical thinning.

Original languageEnglish
Pages (from-to)32-39
Number of pages8
JournalNeurobiology of Aging
Publication statusPublished - 2018 Dec

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Ageing
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology

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    Lee, Y. G., Jeon, S., Yoo, H. S., Chung, S. J., Lee, S. K., Lee, P. H., Sohn, Y. H., Yun, M., Evans, A. C., & Ye, B. S. (2018). Amyloid-β-related and unrelated cortical thinning in dementia with Lewy bodies. Neurobiology of Aging, 72, 32-39.