Amyloid-β-related and unrelated cortical thinning in dementia with Lewy bodies

Young gun Lee, Seun Jeon, Han Soo Yoo, Seok Jong Chung, Seung Koo Lee, Phil Hyu Lee, Young Ho Sohn, Mijin Yun, Alan C. Evans, Byoung Seok Ye

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Coexisting Alzheimer's disease (AD) pathology is common in patients with dementia with Lewy bodies (DLB). To evaluate the cortical thinning in patients with DLB considering the effect of amyloid-β (Aβ), we compared the regional cortical thickness between control subjects and patients with DLB with abnormal dopamine transporter imaging. Seventeen (43.6%) of 39 patients with DLB and no control subjects had significant Aβ deposition on 18F-florbetaben positron emission tomography. Compared to control (n = 15), Aβ-negative DLB group (n = 21) had cortical thinning in the bilateral insula, entorhinal, basal frontal, and occipito-parietal cortices. Compared to Aβ-negative DLB, Aβ-positive DLB group (n = 15) had a lower cortical thickness in the AD-prone brain regions in addition to the bilateral occipital, basal frontal, and somatomotor cortices. After controlling for the amount of Aβ deposition, DLB group had cortical thinning in the same regions affected in the Aβ-negative DLB group. In summary, patients with DLB had an Aβ-independent cortical thinning, while Aβ was associated with additional cortical thinning in the AD-prone brain regions and the aggravation of DLB-specific cortical thinning.

Original languageEnglish
Pages (from-to)32-39
Number of pages8
JournalNeurobiology of Aging
Volume72
DOIs
Publication statusPublished - 2018 Dec

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Lewy Body Disease
Amyloid
Alzheimer Disease
Parietal Lobe
Dopamine Plasma Membrane Transport Proteins
Brain
Frontal Lobe
Positron-Emission Tomography

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Ageing
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology

Cite this

Lee, Young gun ; Jeon, Seun ; Yoo, Han Soo ; Chung, Seok Jong ; Lee, Seung Koo ; Lee, Phil Hyu ; Sohn, Young Ho ; Yun, Mijin ; Evans, Alan C. ; Ye, Byoung Seok. / Amyloid-β-related and unrelated cortical thinning in dementia with Lewy bodies. In: Neurobiology of Aging. 2018 ; Vol. 72. pp. 32-39.
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abstract = "Coexisting Alzheimer's disease (AD) pathology is common in patients with dementia with Lewy bodies (DLB). To evaluate the cortical thinning in patients with DLB considering the effect of amyloid-β (Aβ), we compared the regional cortical thickness between control subjects and patients with DLB with abnormal dopamine transporter imaging. Seventeen (43.6{\%}) of 39 patients with DLB and no control subjects had significant Aβ deposition on 18F-florbetaben positron emission tomography. Compared to control (n = 15), Aβ-negative DLB group (n = 21) had cortical thinning in the bilateral insula, entorhinal, basal frontal, and occipito-parietal cortices. Compared to Aβ-negative DLB, Aβ-positive DLB group (n = 15) had a lower cortical thickness in the AD-prone brain regions in addition to the bilateral occipital, basal frontal, and somatomotor cortices. After controlling for the amount of Aβ deposition, DLB group had cortical thinning in the same regions affected in the Aβ-negative DLB group. In summary, patients with DLB had an Aβ-independent cortical thinning, while Aβ was associated with additional cortical thinning in the AD-prone brain regions and the aggravation of DLB-specific cortical thinning.",
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Lee, YG, Jeon, S, Yoo, HS, Chung, SJ, Lee, SK, Lee, PH, Sohn, YH, Yun, M, Evans, AC & Ye, BS 2018, 'Amyloid-β-related and unrelated cortical thinning in dementia with Lewy bodies', Neurobiology of Aging, vol. 72, pp. 32-39. https://doi.org/10.1016/j.neurobiolaging.2018.08.007

Amyloid-β-related and unrelated cortical thinning in dementia with Lewy bodies. / Lee, Young gun; Jeon, Seun; Yoo, Han Soo; Chung, Seok Jong; Lee, Seung Koo; Lee, Phil Hyu; Sohn, Young Ho; Yun, Mijin; Evans, Alan C.; Ye, Byoung Seok.

In: Neurobiology of Aging, Vol. 72, 12.2018, p. 32-39.

Research output: Contribution to journalArticle

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AU - Lee, Young gun

AU - Jeon, Seun

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AU - Chung, Seok Jong

AU - Lee, Seung Koo

AU - Lee, Phil Hyu

AU - Sohn, Young Ho

AU - Yun, Mijin

AU - Evans, Alan C.

AU - Ye, Byoung Seok

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AB - Coexisting Alzheimer's disease (AD) pathology is common in patients with dementia with Lewy bodies (DLB). To evaluate the cortical thinning in patients with DLB considering the effect of amyloid-β (Aβ), we compared the regional cortical thickness between control subjects and patients with DLB with abnormal dopamine transporter imaging. Seventeen (43.6%) of 39 patients with DLB and no control subjects had significant Aβ deposition on 18F-florbetaben positron emission tomography. Compared to control (n = 15), Aβ-negative DLB group (n = 21) had cortical thinning in the bilateral insula, entorhinal, basal frontal, and occipito-parietal cortices. Compared to Aβ-negative DLB, Aβ-positive DLB group (n = 15) had a lower cortical thickness in the AD-prone brain regions in addition to the bilateral occipital, basal frontal, and somatomotor cortices. After controlling for the amount of Aβ deposition, DLB group had cortical thinning in the same regions affected in the Aβ-negative DLB group. In summary, patients with DLB had an Aβ-independent cortical thinning, while Aβ was associated with additional cortical thinning in the AD-prone brain regions and the aggravation of DLB-specific cortical thinning.

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