Coexisting Alzheimer's disease (AD) pathology is common in patients with dementia with Lewy bodies (DLB). To evaluate the cortical thinning in patients with DLB considering the effect of amyloid-β (Aβ), we compared the regional cortical thickness between control subjects and patients with DLB with abnormal dopamine transporter imaging. Seventeen (43.6%) of 39 patients with DLB and no control subjects had significant Aβ deposition on 18F-florbetaben positron emission tomography. Compared to control (n = 15), Aβ-negative DLB group (n = 21) had cortical thinning in the bilateral insula, entorhinal, basal frontal, and occipito-parietal cortices. Compared to Aβ-negative DLB, Aβ-positive DLB group (n = 15) had a lower cortical thickness in the AD-prone brain regions in addition to the bilateral occipital, basal frontal, and somatomotor cortices. After controlling for the amount of Aβ deposition, DLB group had cortical thinning in the same regions affected in the Aβ-negative DLB group. In summary, patients with DLB had an Aβ-independent cortical thinning, while Aβ was associated with additional cortical thinning in the AD-prone brain regions and the aggravation of DLB-specific cortical thinning.
|Number of pages||8|
|Journal||Neurobiology of Aging|
|Publication status||Published - 2018 Dec|
Bibliographical noteFunding Information:
This research was supported by a faculty research grant from Yonsei University College of Medicine (6-2016-0080), a grant from National Research Foundation of Korea Grant funded by the Korean Government (NRF-2016R1C1B1015044), and a grant from Canadian Institute of Health Research (CIHR) awarded to Professor Alan C. Evans (201085 and 247003). SJ is the recipient of following fellowships that contribute to his support: Bourse Fonds de Recherche Santé Québec (FRQS, dossier 34240 & 259605) and the Jeanne Timmins Costello Fellowship of the Montreal Neurological Institute (240522).
All Science Journal Classification (ASJC) codes
- Clinical Neurology
- Developmental Biology
- Geriatrics and Gerontology