Abstract
Coexisting Alzheimer's disease (AD) pathology is common in patients with dementia with Lewy bodies (DLB). To evaluate the cortical thinning in patients with DLB considering the effect of amyloid-β (Aβ), we compared the regional cortical thickness between control subjects and patients with DLB with abnormal dopamine transporter imaging. Seventeen (43.6%) of 39 patients with DLB and no control subjects had significant Aβ deposition on 18F-florbetaben positron emission tomography. Compared to control (n = 15), Aβ-negative DLB group (n = 21) had cortical thinning in the bilateral insula, entorhinal, basal frontal, and occipito-parietal cortices. Compared to Aβ-negative DLB, Aβ-positive DLB group (n = 15) had a lower cortical thickness in the AD-prone brain regions in addition to the bilateral occipital, basal frontal, and somatomotor cortices. After controlling for the amount of Aβ deposition, DLB group had cortical thinning in the same regions affected in the Aβ-negative DLB group. In summary, patients with DLB had an Aβ-independent cortical thinning, while Aβ was associated with additional cortical thinning in the AD-prone brain regions and the aggravation of DLB-specific cortical thinning.
| Original language | English |
|---|---|
| Pages (from-to) | 32-39 |
| Number of pages | 8 |
| Journal | Neurobiology of Aging |
| Volume | 72 |
| DOIs | |
| Publication status | Published - 2018 Dec |
Fingerprint
All Science Journal Classification (ASJC) codes
- Neuroscience(all)
- Ageing
- Clinical Neurology
- Developmental Biology
- Geriatrics and Gerontology
Cite this
}
Amyloid-β-related and unrelated cortical thinning in dementia with Lewy bodies. / Lee, Young gun; Jeon, Seun; Yoo, Han Soo; Chung, Seok Jong; Lee, Seung Koo; Lee, Phil Hyu; Sohn, Young Ho; Yun, Mijin; Evans, Alan C.; Ye, Byoung Seok.
In: Neurobiology of Aging, Vol. 72, 12.2018, p. 32-39.Research output: Contribution to journal › Article
TY - JOUR
T1 - Amyloid-β-related and unrelated cortical thinning in dementia with Lewy bodies
AU - Lee, Young gun
AU - Jeon, Seun
AU - Yoo, Han Soo
AU - Chung, Seok Jong
AU - Lee, Seung Koo
AU - Lee, Phil Hyu
AU - Sohn, Young Ho
AU - Yun, Mijin
AU - Evans, Alan C.
AU - Ye, Byoung Seok
PY - 2018/12
Y1 - 2018/12
N2 - Coexisting Alzheimer's disease (AD) pathology is common in patients with dementia with Lewy bodies (DLB). To evaluate the cortical thinning in patients with DLB considering the effect of amyloid-β (Aβ), we compared the regional cortical thickness between control subjects and patients with DLB with abnormal dopamine transporter imaging. Seventeen (43.6%) of 39 patients with DLB and no control subjects had significant Aβ deposition on 18F-florbetaben positron emission tomography. Compared to control (n = 15), Aβ-negative DLB group (n = 21) had cortical thinning in the bilateral insula, entorhinal, basal frontal, and occipito-parietal cortices. Compared to Aβ-negative DLB, Aβ-positive DLB group (n = 15) had a lower cortical thickness in the AD-prone brain regions in addition to the bilateral occipital, basal frontal, and somatomotor cortices. After controlling for the amount of Aβ deposition, DLB group had cortical thinning in the same regions affected in the Aβ-negative DLB group. In summary, patients with DLB had an Aβ-independent cortical thinning, while Aβ was associated with additional cortical thinning in the AD-prone brain regions and the aggravation of DLB-specific cortical thinning.
AB - Coexisting Alzheimer's disease (AD) pathology is common in patients with dementia with Lewy bodies (DLB). To evaluate the cortical thinning in patients with DLB considering the effect of amyloid-β (Aβ), we compared the regional cortical thickness between control subjects and patients with DLB with abnormal dopamine transporter imaging. Seventeen (43.6%) of 39 patients with DLB and no control subjects had significant Aβ deposition on 18F-florbetaben positron emission tomography. Compared to control (n = 15), Aβ-negative DLB group (n = 21) had cortical thinning in the bilateral insula, entorhinal, basal frontal, and occipito-parietal cortices. Compared to Aβ-negative DLB, Aβ-positive DLB group (n = 15) had a lower cortical thickness in the AD-prone brain regions in addition to the bilateral occipital, basal frontal, and somatomotor cortices. After controlling for the amount of Aβ deposition, DLB group had cortical thinning in the same regions affected in the Aβ-negative DLB group. In summary, patients with DLB had an Aβ-independent cortical thinning, while Aβ was associated with additional cortical thinning in the AD-prone brain regions and the aggravation of DLB-specific cortical thinning.
UR - http://www.scopus.com/inward/record.url?scp=85052970115&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85052970115&partnerID=8YFLogxK
U2 - 10.1016/j.neurobiolaging.2018.08.007
DO - 10.1016/j.neurobiolaging.2018.08.007
M3 - Article
C2 - 30205358
AN - SCOPUS:85052970115
VL - 72
SP - 32
EP - 39
JO - Neurobiology of Aging
JF - Neurobiology of Aging
SN - 0197-4580
ER -