An age-related decline of CD62L and vaccine response: A role of microRNA 92a?

Jaeil Shin, Jagadeesh Bayry

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Aging process can affect T cell and antibody response to vaccination and an age-related decline in the expression of CD62L on CD8+ T-lymphocyte is one of the important factors that contribute. A recent report demonstrated that percentage of CD3+CD8+CD62L+ cells and CD8+ T-lymphocyte microRNA-92a levels significantly decline with the age and were positively correlated. These results suggested that the age-related attrition of human naïve T cells could be connected to a reduced microRNA-92a in T-lymphocytes and downregulation of the microRNA-92a level might indicate exhaustion of naïve T-cells due to alteration of the immunologic condition with aging. Further studies are necessary to evaluate whether targeting microRNA-92a as microRNA mimics could be one of the therapeutic strategies in improving vaccine response in elderly.

Original languageEnglish
Pages (from-to)1404-1405
Number of pages2
JournalHuman Vaccines and Immunotherapeutics
Volume10
Issue number5
DOIs
Publication statusPublished - 2014 Jan 1

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MicroRNAs
Vaccines
T-Lymphocytes
Antibody Formation
Vaccination
Down-Regulation

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Pharmacology

Cite this

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title = "An age-related decline of CD62L and vaccine response: A role of microRNA 92a?",
abstract = "Aging process can affect T cell and antibody response to vaccination and an age-related decline in the expression of CD62L on CD8+ T-lymphocyte is one of the important factors that contribute. A recent report demonstrated that percentage of CD3+CD8+CD62L+ cells and CD8+ T-lymphocyte microRNA-92a levels significantly decline with the age and were positively correlated. These results suggested that the age-related attrition of human na{\"i}ve T cells could be connected to a reduced microRNA-92a in T-lymphocytes and downregulation of the microRNA-92a level might indicate exhaustion of na{\"i}ve T-cells due to alteration of the immunologic condition with aging. Further studies are necessary to evaluate whether targeting microRNA-92a as microRNA mimics could be one of the therapeutic strategies in improving vaccine response in elderly.",
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An age-related decline of CD62L and vaccine response : A role of microRNA 92a? / Shin, Jaeil; Bayry, Jagadeesh.

In: Human Vaccines and Immunotherapeutics, Vol. 10, No. 5, 01.01.2014, p. 1404-1405.

Research output: Contribution to journalArticle

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