Cyclo-(l-Pro-l-Met) was isolated from the fermentation broth of a marine-derived actinomycete Nocardiopsis sp. 03N67 by chromatographic analysis and showed anti-angiogenesis activity against human umbilical vein endothelial cells (HUVECs). The structure and absolute stereochemistry of this compound were determined based on extensive spectroscopic data analysis, and Marfey's method, respectively.
Bibliographical noteFunding Information:
The authors express gratitude to Y.H. Kim, Korea Basic Science Institute, Daejeon, Korea, for providing mass data. This research was supported in part by the Ministry of Land, Transport and Maritime Affairs, Korea , Korea Ocean Research and Development Institute (Grants PE98472 to D.H.K. and PE98494 to H.S.P.) and the Translational Research Center for Protein Function Control ( NRF 2009-0083522 to H.J.K.).
All Science Journal Classification (ASJC) codes
- Agronomy and Crop Science
- Plant Science