An anti-adhesion technique in microfluidic channel using dielectrophoresis for particle processing microfluidic chip applications

Dong Hyun Kang, Min Gu Kim, Hye Kyoung Seo, Yong Jun Kim

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Particle adhesion to the walls of microfluidic channels is a prominent cause of deteriorating performance and reliability in miniaturized analytical devices; it can also cause unexpected changes in their structures and operating conditions. Therefore, the demand of anti-adhesion for wall loss reduction on particle processing chips is high. This paper demonstrates an anti-adhesion technique using dielectrophoresis. The proposed technique is applied to a distribution microchannel for a feasibility test and is then applied to a blood plasma filter, which is a human blood cell and plasma separation device. In the distribution microchannel, the application of electric potentials of 0-20 VPP at 3 MHz caused the wall loss of polystyrene latex (PSL) particles to decrease with decreasing particle diameter. When an electric potential of 20 VPP was applied in a distribution microchannel experiment using PSL particles, the wall loss decreased by 52.7±3% for 10-μm-diameter particles. On the other hand, when a 20 VPP electric potential was applied in a distribution microchannel experiment using human blood cells, the wall loss decreased by 66.4±6%. In the blood plasma filter, the wall loss decreased by 54.89±5% at 20 VPP and 1 MHz. The purity efficiency of the blood plasma filter was 69.56% without the wall loss reduction technique and 95.14% when the applied electric potential was 20 VPP.

Original languageEnglish
Pages (from-to)1524-1534
Number of pages11
JournalJournal of Biomedical Nanotechnology
Volume11
Issue number9
DOIs
Publication statusPublished - 2015 Sep 1

Fingerprint

Microfluidics
Electrophoresis
Adhesion
Microchannels
Blood
Processing
Microspheres
Particles (particulate matter)
Plasmas
Blood Cells
Electric potential
Latexes
Equipment and Supplies
Cell Separation
Polystyrenes
Cells
Cell Wall
Experiments
styrofoam

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomedical Engineering
  • Materials Science(all)
  • Pharmaceutical Science

Cite this

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title = "An anti-adhesion technique in microfluidic channel using dielectrophoresis for particle processing microfluidic chip applications",
abstract = "Particle adhesion to the walls of microfluidic channels is a prominent cause of deteriorating performance and reliability in miniaturized analytical devices; it can also cause unexpected changes in their structures and operating conditions. Therefore, the demand of anti-adhesion for wall loss reduction on particle processing chips is high. This paper demonstrates an anti-adhesion technique using dielectrophoresis. The proposed technique is applied to a distribution microchannel for a feasibility test and is then applied to a blood plasma filter, which is a human blood cell and plasma separation device. In the distribution microchannel, the application of electric potentials of 0-20 VPP at 3 MHz caused the wall loss of polystyrene latex (PSL) particles to decrease with decreasing particle diameter. When an electric potential of 20 VPP was applied in a distribution microchannel experiment using PSL particles, the wall loss decreased by 52.7±3{\%} for 10-μm-diameter particles. On the other hand, when a 20 VPP electric potential was applied in a distribution microchannel experiment using human blood cells, the wall loss decreased by 66.4±6{\%}. In the blood plasma filter, the wall loss decreased by 54.89±5{\%} at 20 VPP and 1 MHz. The purity efficiency of the blood plasma filter was 69.56{\%} without the wall loss reduction technique and 95.14{\%} when the applied electric potential was 20 VPP.",
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An anti-adhesion technique in microfluidic channel using dielectrophoresis for particle processing microfluidic chip applications. / Kang, Dong Hyun; Kim, Min Gu; Seo, Hye Kyoung; Kim, Yong Jun.

In: Journal of Biomedical Nanotechnology, Vol. 11, No. 9, 01.09.2015, p. 1524-1534.

Research output: Contribution to journalArticle

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