An anti-adhesion technique in microfluidic channel using dielectrophoresis for particle processing microfluidic chip applications

Dong Hyun Kang, Min Gu Kim, Hye Kyoung Seo, Yong Jun Kim

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Particle adhesion to the walls of microfluidic channels is a prominent cause of deteriorating performance and reliability in miniaturized analytical devices; it can also cause unexpected changes in their structures and operating conditions. Therefore, the demand of anti-adhesion for wall loss reduction on particle processing chips is high. This paper demonstrates an anti-adhesion technique using dielectrophoresis. The proposed technique is applied to a distribution microchannel for a feasibility test and is then applied to a blood plasma filter, which is a human blood cell and plasma separation device. In the distribution microchannel, the application of electric potentials of 0-20 VPP at 3 MHz caused the wall loss of polystyrene latex (PSL) particles to decrease with decreasing particle diameter. When an electric potential of 20 VPP was applied in a distribution microchannel experiment using PSL particles, the wall loss decreased by 52.7±3% for 10-μm-diameter particles. On the other hand, when a 20 VPP electric potential was applied in a distribution microchannel experiment using human blood cells, the wall loss decreased by 66.4±6%. In the blood plasma filter, the wall loss decreased by 54.89±5% at 20 VPP and 1 MHz. The purity efficiency of the blood plasma filter was 69.56% without the wall loss reduction technique and 95.14% when the applied electric potential was 20 VPP.

Original languageEnglish
Pages (from-to)1524-1534
Number of pages11
JournalJournal of Biomedical Nanotechnology
Volume11
Issue number9
DOIs
Publication statusPublished - 2015 Sep 1

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All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomedical Engineering
  • Materials Science(all)
  • Pharmaceutical Science

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