An apoptosis-inducing small molecule that binds to heat shock protein 70

Darren R. Williams, Sung Kyun Ko, Sungjin Park, Myung Ryul Lee, Injae Shin

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(Chemical Equation Presented) A cell-based screening approach in which annexin V was used as a staining agent identified apoptozole (Az; see scheme) as an imidazole-based molecule which induces apoptosis. Az binds to Hsc70 and Hsp70 (anti-apoptotic chaperone proteins), with dissociation constants of 0.21 and 0.14 μm, respectively, thereby inhibiting their function. Thus, Az possesses antitumor activity and is, therefore, a potential cancer therapeutic agent.

Original languageEnglish
Pages (from-to)7466-7469
Number of pages4
JournalAngewandte Chemie - International Edition
Issue number39
Publication statusPublished - 2008 Sep 15


All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)

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