An Arched Micro-Injector (ARCMI) for innocuous subretinal injection

Yong Sung You, Chang Yeol Lee, Chengguo Li, Sung Ho Lee, Kibom Kim, Hyungil Jung

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Several critical ocular diseases that can lead to blindness are due to retinal disorders. Subretinal drug delivery has been developed recently for the treatment of retinal disorders such as hemorrhage because of the specific ocular structure, namely, the blood retinal barrier (BRB). In the present study, we developed an Arched Micro-injector (ARCMI) for subretinal drug delivery with minimal retinal tissue damage. ARCMIs were fabricated using three major techniques: reverse drawing lithography, controlled air flow, and electroplating. In order to achieve minimal retinal tissue damage, ARCMIs were fabricated with specific features such as a 0.15 mm-1 curvature, 45° tip bevel, 5 mm length, inner diameter of 40 μm, and an outer diameter of 100 μm. These specific features were optimized via in-vitro experiments in artificial ocular hemispherical structures and subretinal injection of indocyanine green in porcine eye ex-vivo. We confirmed that the ARCMI was capable of delivering ocular drugs by subretinal injection without unusual subretinal tissue damage, including hemorrhage.

Original languageEnglish
Article numbere104145
JournalPloS one
Volume9
Issue number8
DOIs
Publication statusPublished - 2014 Aug 11

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

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