An area/power efficient electrode-matched neural-spike detector embedded in implantable 256-channel MEA

Myungjin Han; Go Eun Ha; Eunji Cheong; Gunhee Han; Youngcheol Chae

doi:10.1109/BIOCAS.2017.8325057

An area/power efficient electrode-matched neural-spike detector embedded in implantable 256-channel MEA

Myungjin Han, Go Eun Ha, Eunji Cheong, Gunhee Han, Youngcheol Chae

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

1 Citation (Scopus)

Abstract

A compact area/power efficient electrode-matched neural-spike detector (NSD) is proposed to provide an implantable multi-electrode array (MEA). A correlation scheme with only the input sampling capacitors makes an area reduction, and the recording of neural-spike events enables a power reduction, showing 0.0044 mm² and 0.55 μW. Together with proposed NSD, an implantable 256-channel MEA is fabricated. The electrical measurement results show that the NSD achieves an input-referred noise of 10.1 μV_rms with 1 kHz to 10 kHz bandwidth, providing NEF/PEF/AEF of 1.71/5.28/0.0044, respectively, and CMRR of 67.5 dB. It shows ×7.5/×1.6 area/power improvements, compared to previous state-of-the-art NSDs. The fabricated implantable MEA is demonstrated by cell-cultured and brain-sliced experiments.

Original language	English
Title of host publication	2017 IEEE Biomedical Circuits and Systems Conference, BioCAS 2017 - Proceedings
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	1-4
Number of pages	4
ISBN (Electronic)	9781509058037
DOIs	https://doi.org/10.1109/BIOCAS.2017.8325057
Publication status	Published - 2018 Mar 23
Event	2017 IEEE Biomedical Circuits and Systems Conference, BioCAS 2017 - Torino, Italy Duration: 2017 Oct 19 → 2017 Oct 21

Publication series

Name	2017 IEEE Biomedical Circuits and Systems Conference, BioCAS 2017 - Proceedings
Volume	2018-January

Other

Other	2017 IEEE Biomedical Circuits and Systems Conference, BioCAS 2017
Country	Italy
City	Torino
Period	17/10/19 → 17/10/21

Bibliographical note

Publisher Copyright:
© 2017 IEEE.

All Science Journal Classification (ASJC) codes

Biomedical Engineering
Electrical and Electronic Engineering
Instrumentation

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10.1109/BIOCAS.2017.8325057

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Han, M., Ha, G. E., Cheong, E., Han, G., & Chae, Y. (2018). An area/power efficient electrode-matched neural-spike detector embedded in implantable 256-channel MEA. In 2017 IEEE Biomedical Circuits and Systems Conference, BioCAS 2017 - Proceedings (pp. 1-4). (2017 IEEE Biomedical Circuits and Systems Conference, BioCAS 2017 - Proceedings; Vol. 2018-January). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/BIOCAS.2017.8325057

Han, Myungjin ; Ha, Go Eun ; Cheong, Eunji ; Han, Gunhee ; Chae, Youngcheol. / An area/power efficient electrode-matched neural-spike detector embedded in implantable 256-channel MEA. 2017 IEEE Biomedical Circuits and Systems Conference, BioCAS 2017 - Proceedings. Institute of Electrical and Electronics Engineers Inc., 2018. pp. 1-4 (2017 IEEE Biomedical Circuits and Systems Conference, BioCAS 2017 - Proceedings).

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title = "An area/power efficient electrode-matched neural-spike detector embedded in implantable 256-channel MEA",

abstract = "A compact area/power efficient electrode-matched neural-spike detector (NSD) is proposed to provide an implantable multi-electrode array (MEA). A correlation scheme with only the input sampling capacitors makes an area reduction, and the recording of neural-spike events enables a power reduction, showing 0.0044 mm2 and 0.55 μW. Together with proposed NSD, an implantable 256-channel MEA is fabricated. The electrical measurement results show that the NSD achieves an input-referred noise of 10.1 μVrms with 1 kHz to 10 kHz bandwidth, providing NEF/PEF/AEF of 1.71/5.28/0.0044, respectively, and CMRR of 67.5 dB. It shows ×7.5/×1.6 area/power improvements, compared to previous state-of-the-art NSDs. The fabricated implantable MEA is demonstrated by cell-cultured and brain-sliced experiments.",

author = "Myungjin Han and Ha, {Go Eun} and Eunji Cheong and Gunhee Han and Youngcheol Chae",

note = "Publisher Copyright: {\textcopyright} 2017 IEEE.; 2017 IEEE Biomedical Circuits and Systems Conference, BioCAS 2017 ; Conference date: 19-10-2017 Through 21-10-2017",

year = "2018",

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doi = "10.1109/BIOCAS.2017.8325057",

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Han, M, Ha, GE, Cheong, E , Han, G & Chae, Y 2018, An area/power efficient electrode-matched neural-spike detector embedded in implantable 256-channel MEA. in 2017 IEEE Biomedical Circuits and Systems Conference, BioCAS 2017 - Proceedings. 2017 IEEE Biomedical Circuits and Systems Conference, BioCAS 2017 - Proceedings, vol. 2018-January, Institute of Electrical and Electronics Engineers Inc., pp. 1-4, 2017 IEEE Biomedical Circuits and Systems Conference, BioCAS 2017, Torino, Italy, 17/10/19. https://doi.org/10.1109/BIOCAS.2017.8325057

An area/power efficient electrode-matched neural-spike detector embedded in implantable 256-channel MEA. / Han, Myungjin; Ha, Go Eun; Cheong, Eunji ; Han, Gunhee ; Chae, Youngcheol.

2017 IEEE Biomedical Circuits and Systems Conference, BioCAS 2017 - Proceedings. Institute of Electrical and Electronics Engineers Inc., 2018. p. 1-4 (2017 IEEE Biomedical Circuits and Systems Conference, BioCAS 2017 - Proceedings; Vol. 2018-January).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

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AU - Han, Myungjin

AU - Ha, Go Eun

AU - Cheong, Eunji

AU - Han, Gunhee

AU - Chae, Youngcheol

PY - 2018/3/23

Y1 - 2018/3/23

N2 - A compact area/power efficient electrode-matched neural-spike detector (NSD) is proposed to provide an implantable multi-electrode array (MEA). A correlation scheme with only the input sampling capacitors makes an area reduction, and the recording of neural-spike events enables a power reduction, showing 0.0044 mm2 and 0.55 μW. Together with proposed NSD, an implantable 256-channel MEA is fabricated. The electrical measurement results show that the NSD achieves an input-referred noise of 10.1 μVrms with 1 kHz to 10 kHz bandwidth, providing NEF/PEF/AEF of 1.71/5.28/0.0044, respectively, and CMRR of 67.5 dB. It shows ×7.5/×1.6 area/power improvements, compared to previous state-of-the-art NSDs. The fabricated implantable MEA is demonstrated by cell-cultured and brain-sliced experiments.

AB - A compact area/power efficient electrode-matched neural-spike detector (NSD) is proposed to provide an implantable multi-electrode array (MEA). A correlation scheme with only the input sampling capacitors makes an area reduction, and the recording of neural-spike events enables a power reduction, showing 0.0044 mm2 and 0.55 μW. Together with proposed NSD, an implantable 256-channel MEA is fabricated. The electrical measurement results show that the NSD achieves an input-referred noise of 10.1 μVrms with 1 kHz to 10 kHz bandwidth, providing NEF/PEF/AEF of 1.71/5.28/0.0044, respectively, and CMRR of 67.5 dB. It shows ×7.5/×1.6 area/power improvements, compared to previous state-of-the-art NSDs. The fabricated implantable MEA is demonstrated by cell-cultured and brain-sliced experiments.

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Han M, Ha GE, Cheong E , Han G , Chae Y. An area/power efficient electrode-matched neural-spike detector embedded in implantable 256-channel MEA. In 2017 IEEE Biomedical Circuits and Systems Conference, BioCAS 2017 - Proceedings. Institute of Electrical and Electronics Engineers Inc. 2018. p. 1-4. (2017 IEEE Biomedical Circuits and Systems Conference, BioCAS 2017 - Proceedings). https://doi.org/10.1109/BIOCAS.2017.8325057

An area/power efficient electrode-matched neural-spike detector embedded in implantable 256-channel MEA

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