An efficient synthesis of risperidone via stille reaction: Antipsychotic, 5-HT2, and dopamine-D2-antagonist

Dong Myung Kim, Min Seok Kang, Jeong Sook Kim, Jin Hyun Jeong

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


Risperidone has been reported to have neuroleptic activity. In this study, risperidone was synthesized using a new method involving a stille reaction, in which 2-methyl-3-vinyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one was synthesized (5). The chemical synthesis process was found to be simple and produced risperidone in a high yield. In addition, can be easily scaled up for large scale synthesis.

Original languageEnglish
Pages (from-to)1019-1022
Number of pages4
JournalArchives of pharmacal research
Issue number9
Publication statusPublished - 2005 Sep 30

Bibliographical note

Funding Information:
This research was supported by the Kyung Hee University, 2005 Research Funding and and Korea Science and Engineering Foundation (M1-0310-22-0002).

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Drug Discovery
  • Organic Chemistry


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