An efficient synthesis of risperidone via stille reaction: Antipsychotic, 5-HT2, and dopamine-D2-antagonist

Dong Myung Kim, Min Seok Kang, Jeong Sook Kim, Jin-Hyun Jeong

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Risperidone has been reported to have neuroleptic activity. In this study, risperidone was synthesized using a new method involving a stille reaction, in which 2-methyl-3-vinyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one was synthesized (5). The chemical synthesis process was found to be simple and produced risperidone in a high yield. In addition, can be easily scaled up for large scale synthesis.

Original languageEnglish
Pages (from-to)1019-1022
Number of pages4
JournalArchives of pharmacal research
Volume28
Issue number9
DOIs
Publication statusPublished - 2005 Sep 30

Fingerprint

Risperidone
Antipsychotic Agents
Chemical Phenomena
Dopamine D2 Receptor Antagonists

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Drug Discovery
  • Organic Chemistry

Cite this

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An efficient synthesis of risperidone via stille reaction : Antipsychotic, 5-HT2, and dopamine-D2-antagonist. / Kim, Dong Myung; Kang, Min Seok; Kim, Jeong Sook; Jeong, Jin-Hyun.

In: Archives of pharmacal research, Vol. 28, No. 9, 30.09.2005, p. 1019-1022.

Research output: Contribution to journalArticle

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