An efficient synthesis of risperidone via stille reaction: Antipsychotic, 5-HT2, and dopamine-D2-antagonist

Dong Myung Kim; Min Seok Kang; Jeong Sook Kim; Jin Hyun Jeong

doi:10.1007/BF02977394

An efficient synthesis of risperidone via stille reaction: Antipsychotic, 5-HT₂, and dopamine-D₂-antagonist

Dong Myung Kim, Min Seok Kang, Jeong Sook Kim, Jin Hyun Jeong

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Risperidone has been reported to have neuroleptic activity. In this study, risperidone was synthesized using a new method involving a stille reaction, in which 2-methyl-3-vinyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one was synthesized (5). The chemical synthesis process was found to be simple and produced risperidone in a high yield. In addition, can be easily scaled up for large scale synthesis.

Original language	English
Pages (from-to)	1019-1022
Number of pages	4
Journal	Archives of pharmacal research
Volume	28
Issue number	9
DOIs	https://doi.org/10.1007/BF02977394
Publication status	Published - 2005 Sept 30

Bibliographical note

Funding Information:
This research was supported by the Kyung Hee University, 2005 Research Funding and and Korea Science and Engineering Foundation (M1-0310-22-0002).

All Science Journal Classification (ASJC) codes

Molecular Medicine
Drug Discovery
Organic Chemistry

Access to Document

10.1007/BF02977394

Cite this

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title = "An efficient synthesis of risperidone via stille reaction: Antipsychotic, 5-HT2, and dopamine-D2-antagonist",

abstract = "Risperidone has been reported to have neuroleptic activity. In this study, risperidone was synthesized using a new method involving a stille reaction, in which 2-methyl-3-vinyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one was synthesized (5). The chemical synthesis process was found to be simple and produced risperidone in a high yield. In addition, can be easily scaled up for large scale synthesis.",

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note = "Funding Information: This research was supported by the Kyung Hee University, 2005 Research Funding and and Korea Science and Engineering Foundation (M1-0310-22-0002).",

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AU - Jeong, Jin Hyun

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