An experimental approach to study the function of mitochondria in cardiomyopathy

Youn Wook Chung, seokmin kang

Research output: Contribution to journalShort survey

2 Citations (Scopus)

Abstract

Cardiomyopathy is an inherited or acquired disease of the myocardium, which can result in severe ventricular dysfunction. Mitochondrial dysfunction is involved in the pathological process of cardiomyopathy. Many dysfunctions in cardiac mitochondria are consequences of mutations in nuclear or mitochondrial DNA followed by alterations in transcriptional regulation, mitochondrial protein function, and mitochondrial dynamics and energetics, presenting with associated multisystem mitochondrial disorders. To ensure correct diagnosis and optimal management of mitochondrial dysfunction in cardiomyopathy caused by multiple pathogenesis, multidisciplinary approaches are required, and to integrate between clinical and basic sciences, ideal translational models are needed. In this review, we will focus on experimental models to provide insights into basic mitochondrial physiology and detailed underlying mechanisms of cardiomyopathy and current mitochondria-targeted therapies for cardiomyopathy.

Original languageEnglish
Pages (from-to)541-548
Number of pages8
JournalBMB reports
Volume48
Issue number10
DOIs
Publication statusPublished - 2015 Jan 1

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Mitochondria
Cardiomyopathies
Mitochondrial Proteins
Physiology
Mitochondrial DNA
Mitochondrial Dynamics
Ventricular Dysfunction
Mitochondrial Diseases
Pathologic Processes
Myocardium
Theoretical Models
Mutation

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology

Cite this

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abstract = "Cardiomyopathy is an inherited or acquired disease of the myocardium, which can result in severe ventricular dysfunction. Mitochondrial dysfunction is involved in the pathological process of cardiomyopathy. Many dysfunctions in cardiac mitochondria are consequences of mutations in nuclear or mitochondrial DNA followed by alterations in transcriptional regulation, mitochondrial protein function, and mitochondrial dynamics and energetics, presenting with associated multisystem mitochondrial disorders. To ensure correct diagnosis and optimal management of mitochondrial dysfunction in cardiomyopathy caused by multiple pathogenesis, multidisciplinary approaches are required, and to integrate between clinical and basic sciences, ideal translational models are needed. In this review, we will focus on experimental models to provide insights into basic mitochondrial physiology and detailed underlying mechanisms of cardiomyopathy and current mitochondria-targeted therapies for cardiomyopathy.",
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An experimental approach to study the function of mitochondria in cardiomyopathy. / Chung, Youn Wook; kang, seokmin.

In: BMB reports, Vol. 48, No. 10, 01.01.2015, p. 541-548.

Research output: Contribution to journalShort survey

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