An Exploratory In Vivo Study on the Effect of Annurca Apple Extract on Hair Growth in Mice

Young In Lee, Seoyoon Ham, Sang Gyu Lee, Inhee Jung, Jangmi Suk, Jinhee Yoo, Su Young Choi, Ju Hee Lee

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Hair loss is an important problem affecting the quality of life in modern society. Recent studies show that Annurca apple extract (AAE), enriched in procyanidin B2 and nutraceuticals, promotes hair growth and induces keratin production. In this study, we investigated the effects of AAE by orally administering AAE in six-week-old C57BL/6 mice once a day for 21 d. We observed improvement in hair length, thickness, weight, and density. The gene expression of two growth factors related to hair growth, vascular endothelial growth factor A (VEGFA) and fibroblast growth factor 7 (FGF-7), were measured using the quantitative reverse transcription polymerase chain reaction (qRT-PCR). The gene expression of both VEGFA and FGF-7 increased significantly in the AAE-treated group. Additionally, treatment with AAE suppressed the gene expression of type 1 5α-reductase. Histological analysis showed that protein levels of cytokeratin 5 and 10 were increased in the skin tissues of the AAE-treated group. These results suggest that AAE might be a potential therapeutic natural product that prevents hair loss by promoting the expression of hair growth-related factors.

Original languageEnglish
Pages (from-to)6280-6289
Number of pages10
JournalCurrent Issues in Molecular Biology
Issue number12
Publication statusPublished - 2022 Dec

Bibliographical note

Funding Information:
This work was supported by the Korea Medical Device Development Fund grant funded by the Republic of Korea government (the Ministry of Science and ICT, the Ministry of Trade, Industry and Energy, the Ministry of Health & Welfare, the Ministry of Food and Drug Safety) (Project Number: 1711174324, RS-2022-KD141479).

Publisher Copyright:
© 2022 by the authors.

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Molecular Biology
  • Microbiology (medical)


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