Abstract
Immunoassay is an important technique to detect the disease biomarkers and pathogenic biological agents which often present at low levels in clinical samples. To improve sensitivity of the immunoassay, here we described the DNA-coated, nano-sized micelles in which the DNA strands play a role as signal generators in an immunoassay. This micelle-based immunoassay was evaluated for quantitation of a liver cancer biomarker and the sensitivity of the method was compared with those of the conventional methods.
| Original language | English |
|---|---|
| Pages (from-to) | 2675-2678 |
| Number of pages | 4 |
| Journal | Bioorganic and Medicinal Chemistry Letters |
| Volume | 23 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - 2013 May 1 |
All Science Journal Classification (ASJC) codes
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Pharmaceutical Science
- Drug Discovery
- Clinical Biochemistry
- Organic Chemistry
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Hoang, H. T., Lee, T., Kim, B. S., Han, K. C., & Ahn, D. R. (2013). An immunoassay utilizing the DNA-coated polydiacetylene micelles as a signal generator. Bioorganic and Medicinal Chemistry Letters, 23(9), 2675-2678. https://doi.org/10.1016/j.bmcl.2013.02.087