An immunoassay utilizing the DNA-coated polydiacetylene micelles as a signal generator

Hoa Thi Hoang, Taemin Lee, Byeong Su Kim, Ki Cheol Han, Dae Ro Ahn

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Immunoassay is an important technique to detect the disease biomarkers and pathogenic biological agents which often present at low levels in clinical samples. To improve sensitivity of the immunoassay, here we described the DNA-coated, nano-sized micelles in which the DNA strands play a role as signal generators in an immunoassay. This micelle-based immunoassay was evaluated for quantitation of a liver cancer biomarker and the sensitivity of the method was compared with those of the conventional methods.

Original languageEnglish
Pages (from-to)2675-2678
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume23
Issue number9
DOIs
Publication statusPublished - 2013 May 1

Fingerprint

Signal generators
Micelles
Immunoassay
DNA
Biological Factors
Biomarkers
Tumor Biomarkers
Liver
Liver Neoplasms
polydiacetylene

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

Hoang, Hoa Thi ; Lee, Taemin ; Kim, Byeong Su ; Han, Ki Cheol ; Ahn, Dae Ro. / An immunoassay utilizing the DNA-coated polydiacetylene micelles as a signal generator. In: Bioorganic and Medicinal Chemistry Letters. 2013 ; Vol. 23, No. 9. pp. 2675-2678.
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An immunoassay utilizing the DNA-coated polydiacetylene micelles as a signal generator. / Hoang, Hoa Thi; Lee, Taemin; Kim, Byeong Su; Han, Ki Cheol; Ahn, Dae Ro.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 23, No. 9, 01.05.2013, p. 2675-2678.

Research output: Contribution to journalArticle

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