An immunoassay utilizing the DNA-coated polydiacetylene micelles as a signal generator

Hoa Thi Hoang; Taemin Lee; Byeong Su Kim; Ki Cheol Han; Dae Ro Ahn

doi:10.1016/j.bmcl.2013.02.087

An immunoassay utilizing the DNA-coated polydiacetylene micelles as a signal generator

Hoa Thi Hoang, Taemin Lee, Byeong Su Kim, Ki Cheol Han, Dae Ro Ahn

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Immunoassay is an important technique to detect the disease biomarkers and pathogenic biological agents which often present at low levels in clinical samples. To improve sensitivity of the immunoassay, here we described the DNA-coated, nano-sized micelles in which the DNA strands play a role as signal generators in an immunoassay. This micelle-based immunoassay was evaluated for quantitation of a liver cancer biomarker and the sensitivity of the method was compared with those of the conventional methods.

Original language	English
Pages (from-to)	2675-2678
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	23
Issue number	9
DOIs	https://doi.org/10.1016/j.bmcl.2013.02.087
Publication status	Published - 2013 May 1

Bibliographical note

Funding Information:
This study was supported by a grant funded by Korea Institute of Science and Technology , a grant of the Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Education ( 2011-0009172 ), grants of the Korea Health technology R&D project, Ministry of Health & Welfare, Republic of Korea ( A090147 and A121191 ), and a grant the Proteogenomic Research Program through the National Research Foundation of Korea funded by the Korean Ministry of Education, Science and Technology .

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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abstract = "Immunoassay is an important technique to detect the disease biomarkers and pathogenic biological agents which often present at low levels in clinical samples. To improve sensitivity of the immunoassay, here we described the DNA-coated, nano-sized micelles in which the DNA strands play a role as signal generators in an immunoassay. This micelle-based immunoassay was evaluated for quantitation of a liver cancer biomarker and the sensitivity of the method was compared with those of the conventional methods.",

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AU - Ahn, Dae Ro

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An immunoassay utilizing the DNA-coated polydiacetylene micelles as a signal generator

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

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