Abstract
Immunoassay is an important technique to detect the disease biomarkers and pathogenic biological agents which often present at low levels in clinical samples. To improve sensitivity of the immunoassay, here we described the DNA-coated, nano-sized micelles in which the DNA strands play a role as signal generators in an immunoassay. This micelle-based immunoassay was evaluated for quantitation of a liver cancer biomarker and the sensitivity of the method was compared with those of the conventional methods.
| Original language | English |
|---|---|
| Pages (from-to) | 2675-2678 |
| Number of pages | 4 |
| Journal | Bioorganic and Medicinal Chemistry Letters |
| Volume | 23 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - 2013 May 1 |
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All Science Journal Classification (ASJC) codes
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Pharmaceutical Science
- Drug Discovery
- Clinical Biochemistry
- Organic Chemistry
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An immunoassay utilizing the DNA-coated polydiacetylene micelles as a signal generator. / Hoang, Hoa Thi; Lee, Taemin; Kim, Byeong Su; Han, Ki Cheol; Ahn, Dae Ro.
In: Bioorganic and Medicinal Chemistry Letters, Vol. 23, No. 9, 01.05.2013, p. 2675-2678.Research output: Contribution to journal › Article
TY - JOUR
T1 - An immunoassay utilizing the DNA-coated polydiacetylene micelles as a signal generator
AU - Hoang, Hoa Thi
AU - Lee, Taemin
AU - Kim, Byeong Su
AU - Han, Ki Cheol
AU - Ahn, Dae Ro
PY - 2013/5/1
Y1 - 2013/5/1
N2 - Immunoassay is an important technique to detect the disease biomarkers and pathogenic biological agents which often present at low levels in clinical samples. To improve sensitivity of the immunoassay, here we described the DNA-coated, nano-sized micelles in which the DNA strands play a role as signal generators in an immunoassay. This micelle-based immunoassay was evaluated for quantitation of a liver cancer biomarker and the sensitivity of the method was compared with those of the conventional methods.
AB - Immunoassay is an important technique to detect the disease biomarkers and pathogenic biological agents which often present at low levels in clinical samples. To improve sensitivity of the immunoassay, here we described the DNA-coated, nano-sized micelles in which the DNA strands play a role as signal generators in an immunoassay. This micelle-based immunoassay was evaluated for quantitation of a liver cancer biomarker and the sensitivity of the method was compared with those of the conventional methods.
UR - http://www.scopus.com/inward/record.url?scp=84876099069&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84876099069&partnerID=8YFLogxK
U2 - 10.1016/j.bmcl.2013.02.087
DO - 10.1016/j.bmcl.2013.02.087
M3 - Article
C2 - 23518279
AN - SCOPUS:84876099069
VL - 23
SP - 2675
EP - 2678
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
SN - 0960-894X
IS - 9
ER -