Immunoassay is an important technique to detect the disease biomarkers and pathogenic biological agents which often present at low levels in clinical samples. To improve sensitivity of the immunoassay, here we described the DNA-coated, nano-sized micelles in which the DNA strands play a role as signal generators in an immunoassay. This micelle-based immunoassay was evaluated for quantitation of a liver cancer biomarker and the sensitivity of the method was compared with those of the conventional methods.
Bibliographical noteFunding Information:
This study was supported by a grant funded by Korea Institute of Science and Technology , a grant of the Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Education ( 2011-0009172 ), grants of the Korea Health technology R&D project, Ministry of Health & Welfare, Republic of Korea ( A090147 and A121191 ), and a grant the Proteogenomic Research Program through the National Research Foundation of Korea funded by the Korean Ministry of Education, Science and Technology .
All Science Journal Classification (ASJC) codes
- Molecular Medicine
- Molecular Biology
- Pharmaceutical Science
- Drug Discovery
- Clinical Biochemistry
- Organic Chemistry