Thiocarbonyl derivatives of secondary alcohols are readily reduced by diphenylsilane in a radical chain process at room temperature using triethylborane-air as an initiator. Primary alcohols react similarly at 80°. Comparison is made with the similar reactivity of tris(trimethylsilyl)silane.
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Acknowledgements. We thank the N.I.H. the support of this work.
All Science Journal Classification (ASJC) codes
- Drug Discovery
- Organic Chemistry