An induced pluripotent stem cell line (YCMi006-A) generated from a patient with hypertrophic cardiomyopathy who carries the ACTA1 mutation p.Ile343Met

Hyoeun Kim; Hyeong Jin Kim; Jaewon Oh; Seung Tae Lee; Dongju Won; Hyo Kyoung Choi; Jong Rak Choi; Sangwoo Kim; Hyoung Pyo Kim; Seok Jun Kim; Sahng Wook Park; Seok Min Kang; Seung Hyun Lee

doi:10.1016/j.scr.2022.102874

An induced pluripotent stem cell line (YCMi006-A) generated from a patient with hypertrophic cardiomyopathy who carries the ACTA1 mutation p.Ile343Met

Hyoeun Kim, Hyeong Jin Kim, Jaewon Oh, Seung Tae Lee, Dongju Won, Hyo Kyoung Choi, Jong Rak Choi, Sangwoo Kim, Hyoung Pyo Kim, Seok Jun Kim, Sahng Wook Park, Seok Min Kang, Seung Hyun Lee

Department of Internal Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Hypertrophic cardiomyopathy (HCM) is a common inherited cardiovascular disease and is characterized by hypertrophy of the left ventricle. We reprogrammed peripheral blood mononuclear cells (PBMCs) from a HCM patient into pluripotent stem cells (iPSC) (YCMi006-A) carrying a heterozygous c.1029C > G mutation in ACTA1. The YCMi006-A cells expressed high levels of pluripotent markers, had a normal 46XX karyotype and demonstrated the capacity to differentiate into derivatives of all three germ layers. This cell line can be a valuable tool for investigating the pathogenesis of HCM.

Original language	English
Article number	102874
Journal	Stem Cell Research
Volume	63
DOIs	https://doi.org/10.1016/j.scr.2022.102874
Publication status	Published - 2022 Aug

Bibliographical note

Funding Information:
This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (No. NRF- 2021R1I1A1A01049625, 2022R1H1A2003919, 2019R1C1C1002334, 2022M3A9B6017424). This study also was supported by a grant from the Korea Food Research Institute funded by the Ministry of Science, ICT & Future Planning (E0210400). This research was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (HI22C0198). The human stem cell line, CMC-hiPSC-011 was provided by the National Stem Cell Bank of Korea (Korea National Institute of Health), originally provided by Catholic University.

Publisher Copyright:
© 2022 The Author(s)

All Science Journal Classification (ASJC) codes

Developmental Biology
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.scr.2022.102874

Cite this

Kim, H., Kim, H. J., Oh, J., Lee, S. T., Won, D., Choi, H. K., Choi, J. R., Kim, S., Kim, H. P., Kim, S. J., Park, S. W., Kang, S. M., & Lee, S. H. (2022). An induced pluripotent stem cell line (YCMi006-A) generated from a patient with hypertrophic cardiomyopathy who carries the ACTA1 mutation p.Ile343Met. Stem Cell Research, 63, [102874]. https://doi.org/10.1016/j.scr.2022.102874

@article{8652e5b51fe54592afb5202a622be965,

title = "An induced pluripotent stem cell line (YCMi006-A) generated from a patient with hypertrophic cardiomyopathy who carries the ACTA1 mutation p.Ile343Met",

abstract = "Hypertrophic cardiomyopathy (HCM) is a common inherited cardiovascular disease and is characterized by hypertrophy of the left ventricle. We reprogrammed peripheral blood mononuclear cells (PBMCs) from a HCM patient into pluripotent stem cells (iPSC) (YCMi006-A) carrying a heterozygous c.1029C > G mutation in ACTA1. The YCMi006-A cells expressed high levels of pluripotent markers, had a normal 46XX karyotype and demonstrated the capacity to differentiate into derivatives of all three germ layers. This cell line can be a valuable tool for investigating the pathogenesis of HCM.",

author = "Hyoeun Kim and Kim, {Hyeong Jin} and Jaewon Oh and Lee, {Seung Tae} and Dongju Won and Choi, {Hyo Kyoung} and Choi, {Jong Rak} and Sangwoo Kim and Kim, {Hyoung Pyo} and Kim, {Seok Jun} and Park, {Sahng Wook} and Kang, {Seok Min} and Lee, {Seung Hyun}",

note = "Funding Information: This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (No. NRF- 2021R1I1A1A01049625, 2022R1H1A2003919, 2019R1C1C1002334, 2022M3A9B6017424). This study also was supported by a grant from the Korea Food Research Institute funded by the Ministry of Science, ICT & Future Planning (E0210400). This research was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (HI22C0198). The human stem cell line, CMC-hiPSC-011 was provided by the National Stem Cell Bank of Korea (Korea National Institute of Health), originally provided by Catholic University. Publisher Copyright: {\textcopyright} 2022 The Author(s)",

year = "2022",

month = aug,

doi = "10.1016/j.scr.2022.102874",

language = "English",

volume = "63",

journal = "Stem Cell Research",

issn = "1873-5061",

publisher = "Elsevier",

}

TY - JOUR

T1 - An induced pluripotent stem cell line (YCMi006-A) generated from a patient with hypertrophic cardiomyopathy who carries the ACTA1 mutation p.Ile343Met

AU - Kim, Hyoeun

AU - Kim, Hyeong Jin

AU - Oh, Jaewon

AU - Lee, Seung Tae

AU - Won, Dongju

AU - Choi, Hyo Kyoung

AU - Choi, Jong Rak

AU - Kim, Sangwoo

AU - Kim, Hyoung Pyo

AU - Kim, Seok Jun

AU - Park, Sahng Wook

AU - Kang, Seok Min

AU - Lee, Seung Hyun

N1 - Funding Information: This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (No. NRF- 2021R1I1A1A01049625, 2022R1H1A2003919, 2019R1C1C1002334, 2022M3A9B6017424). This study also was supported by a grant from the Korea Food Research Institute funded by the Ministry of Science, ICT & Future Planning (E0210400). This research was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (HI22C0198). The human stem cell line, CMC-hiPSC-011 was provided by the National Stem Cell Bank of Korea (Korea National Institute of Health), originally provided by Catholic University. Publisher Copyright: © 2022 The Author(s)

PY - 2022/8

Y1 - 2022/8

N2 - Hypertrophic cardiomyopathy (HCM) is a common inherited cardiovascular disease and is characterized by hypertrophy of the left ventricle. We reprogrammed peripheral blood mononuclear cells (PBMCs) from a HCM patient into pluripotent stem cells (iPSC) (YCMi006-A) carrying a heterozygous c.1029C > G mutation in ACTA1. The YCMi006-A cells expressed high levels of pluripotent markers, had a normal 46XX karyotype and demonstrated the capacity to differentiate into derivatives of all three germ layers. This cell line can be a valuable tool for investigating the pathogenesis of HCM.

AB - Hypertrophic cardiomyopathy (HCM) is a common inherited cardiovascular disease and is characterized by hypertrophy of the left ventricle. We reprogrammed peripheral blood mononuclear cells (PBMCs) from a HCM patient into pluripotent stem cells (iPSC) (YCMi006-A) carrying a heterozygous c.1029C > G mutation in ACTA1. The YCMi006-A cells expressed high levels of pluripotent markers, had a normal 46XX karyotype and demonstrated the capacity to differentiate into derivatives of all three germ layers. This cell line can be a valuable tool for investigating the pathogenesis of HCM.

UR - http://www.scopus.com/inward/record.url?scp=85135140302&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85135140302&partnerID=8YFLogxK

U2 - 10.1016/j.scr.2022.102874

DO - 10.1016/j.scr.2022.102874

M3 - Article

C2 - 35917599

AN - SCOPUS:85135140302

SN - 1873-5061

VL - 63

JO - Stem Cell Research

JF - Stem Cell Research

M1 - 102874

ER -

An induced pluripotent stem cell line (YCMi006-A) generated from a patient with hypertrophic cardiomyopathy who carries the ACTA1 mutation p.Ile343Met

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this