An integrated photo-thermal sensing system for rapid and direct diagnosis of anemia

Bong Seop Kwak, Hyung Joon Kim, Hyun Ok Kim, Hyo Il Jung

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

This article presents a thermal biosensor to diagnose the anemia without chemical treatments using temperature increase of red blood cells (RBC) when hemoglobin molecules absorb specific wavelength of photons and convert them to thermal energy. For measuring temperature change of red blood cell, the micro-scaled platinum resistance temperature detector (Pt RTD) was developed. For maintenance of constant ambient temperature, we designed and fabricated a thermostat system. The thermostat system consists of a K-type thermocouple and two electric heaters that serve to increase the system temperature, which is monitored by the thermocouple. Both heaters and the thermocouple were connected to a proportional-integral-derivative (PID) controller and enabled to maintain the temperature constant (<±0.1°C). For specific heating of red blood cell, 8.0W/cm2 diode pumped solid state (DPSS) continuous wave (CW) laser module was used with 532nm wavelength. Using this system, we successfully measured the temperature variations (from 66.33±2.72°C to 74.16±2.06°C) of whole blood samples from 10 anemic patients and subsequently determined the concentration of hemoglobin (from 7.2g/dL to 9.8g/dL). The method proposed in this paper requires significantly less amount of whole blood sample (6μl) compared with the conventional methods (175μl) and allows instantaneous diagnosis (3s) of anemia.

Original languageEnglish
Pages (from-to)1679-1683
Number of pages5
JournalBiosensors and Bioelectronics
Volume26
Issue number4
DOIs
Publication statusPublished - 2010 Dec 15

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Biophysics
  • Biomedical Engineering
  • Electrochemistry

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