An NBD-based colorimetric and fluorescent chemosensor for Zn2+ and its use for detection of intracellular zinc ions

Zhaochao Xu, Gun Hee Kim, Su Jung Han, Min Jung Jou, Chongmok Lee, Injae Shin, Juyoung Yoon

Research output: Contribution to journalArticle

137 Citations (Scopus)

Abstract

A new 7-nitrobenz-2-oxa-1,3-diazole (NBD) based colorimetric and fluorescence chemosensor for Zn2+, an ion involved in many biological processes, was designed and synthesized. The NBD-probe 1 displays a red-to-yellow color change and an enhancement of fluorescent intensity in the presence of an aqueous solution of Zn2+ ions (pH 7.2). Internal charge transfer (ICT) and photoinduced electron transfer (PET) mechanisms are responsible for these changes. The practical use of this probe was demonstrated by its application to the biologically relevant detection of Zn2+ ions in pancreatic β-cells.

Original languageEnglish
Pages (from-to)2307-2312
Number of pages6
JournalTetrahedron
Volume65
Issue number11
DOIs
Publication statusPublished - 2009 Mar 14

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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