Abstract Background This phase 2 study investigated the efficacy and safety of dovitinib (TKI258), a receptor tyrosine kinase inhibitor with potent activity against fibroblast growth factor receptor (FGFR) and vascular endothelial growth factor receptor (VEGFR), in locally advanced or metastatic thyroid cancer patients. Patients and methods Patients with advanced thyroid cancer that was refractory or not appropriate for 131I received dovitinib orally, 500 mg once daily for five consecutive days, followed by a 2-day rest every week. The primary end-point was objective response rate. Secondary end-points were progression-free survival (PFS), overall survival (OS), duration of response, changes in tumour markers and safety. Results Between January 2013 and October 2014, a total of 40 patients were enrolled. There were 23 (57.5%) papillary thyroid cancer, 12 (30%) medullary thyroid cancer and 5 (12.5%) follicular thyroid cancer patients. One patient had withdrawn consent before the administration of dovitinib. The overall response rate was 20.5% (8/39) and disease control rate was 69.1% (26/39). Median PFS was 5.4 months (95% confidence interval (CI), 2.0-8.8) and median OS was not reached with 8.4 months follow-up duration. Common treatment-related adverse events were diarrhoea (53.8%), anorexia (35.8%), vomiting (25.6%), fatigue (23%) and nausea (20.5%), most of which were grade 1 or 2. There were no grade 4 events or treatment-related deaths. Dose interruption occurred in 12 (30.7%) patients, and 19 (48.7%) patients experienced dose reduction due to adverse events. Conclusions Dovitinib has a modest activity with manageable toxicity in locally advanced or metastatic thyroid cancer.
Bibliographical noteFunding Information:
This work was supported in part by the National Research Foundation of Korea (NRF) funded by the Korea government (MEST) ( 2012R1A2A2A01046927 to B.C. Cho), and a grant from the Korean Health Technology R&D Project, Ministry of Health & Welfare, Republic of Korea ( HI13C1948 to H.R. Kim).
© 2015 Elsevier Ltd.
All Science Journal Classification (ASJC) codes
- Cancer Research