An orthotopic and osteolytic model with a newly established oral squamous cell carcinoma cell line

Young Sun Hwang, Xianglan Zhang, Kwang Kyun Park, WonYoon Chung

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Objective: Despite the availability of advanced clinical diagnostic systems, the overall 5-year survival rate for patients with oral squamous cell carcinoma (OSCC) has remained relatively poor over the past 2 decades. Appropriate animal models need to be developed according to the specific purpose of cancer research. However, most of the currently available oral cancer cell lines do not precisely reflect the characteristics of bone-invasive OSCC and cannot serve as suitable tools in the development of new therapeutic reagents against bone-invasive OSCC. Here, we assessed the orthotopic and osteolytic mouse model with newly established OSCC cell line. Design: We assessed the orthotopic and osteolytic mouse model using the newly established OSCC cells. In addition, the incidences of tumorigenesis and histopathological results were determined. Results: The newly established YD-39 cell line grows in a monolayer sheet and has highly invasive. The transplanted YD-39 cells developed stable tumours in the tongues and calvaria region of the nude mice. The tumours in nude mice grafted with YD-39 cells had a high incidence of transplantability in both mouse models tested and a similar morphology to their respective original tumour. Therefore, both animal models might be feasible animal models to assess the efficacy of anti-cancer drugs. Conclusions: This type of animal model approach might be has the added advantage of potentially accelerating the biological discovery process.

Original languageEnglish
Pages (from-to)218-225
Number of pages8
JournalArchives of Oral Biology
Volume58
Issue number2
DOIs
Publication statusPublished - 2013 Jan 1

Fingerprint

Squamous Cell Carcinoma
Cell Line
Animal Models
Neoplasms
Nude Mice
Biological Phenomena
Bone and Bones
Mouth Neoplasms
Incidence
Tongue
Skull
Carcinogenesis
Survival Rate
Research
Pharmaceutical Preparations
Therapeutics

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology
  • Dentistry(all)
  • Cell Biology

Cite this

Hwang, Young Sun ; Zhang, Xianglan ; Park, Kwang Kyun ; Chung, WonYoon. / An orthotopic and osteolytic model with a newly established oral squamous cell carcinoma cell line. In: Archives of Oral Biology. 2013 ; Vol. 58, No. 2. pp. 218-225.
@article{25c069e72b4f4393aa6cabb2c96554ab,
title = "An orthotopic and osteolytic model with a newly established oral squamous cell carcinoma cell line",
abstract = "Objective: Despite the availability of advanced clinical diagnostic systems, the overall 5-year survival rate for patients with oral squamous cell carcinoma (OSCC) has remained relatively poor over the past 2 decades. Appropriate animal models need to be developed according to the specific purpose of cancer research. However, most of the currently available oral cancer cell lines do not precisely reflect the characteristics of bone-invasive OSCC and cannot serve as suitable tools in the development of new therapeutic reagents against bone-invasive OSCC. Here, we assessed the orthotopic and osteolytic mouse model with newly established OSCC cell line. Design: We assessed the orthotopic and osteolytic mouse model using the newly established OSCC cells. In addition, the incidences of tumorigenesis and histopathological results were determined. Results: The newly established YD-39 cell line grows in a monolayer sheet and has highly invasive. The transplanted YD-39 cells developed stable tumours in the tongues and calvaria region of the nude mice. The tumours in nude mice grafted with YD-39 cells had a high incidence of transplantability in both mouse models tested and a similar morphology to their respective original tumour. Therefore, both animal models might be feasible animal models to assess the efficacy of anti-cancer drugs. Conclusions: This type of animal model approach might be has the added advantage of potentially accelerating the biological discovery process.",
author = "Hwang, {Young Sun} and Xianglan Zhang and Park, {Kwang Kyun} and WonYoon Chung",
year = "2013",
month = "1",
day = "1",
doi = "10.1016/j.archoralbio.2012.04.023",
language = "English",
volume = "58",
pages = "218--225",
journal = "Archives of Oral Biology",
issn = "0003-9969",
publisher = "Elsevier Limited",
number = "2",

}

An orthotopic and osteolytic model with a newly established oral squamous cell carcinoma cell line. / Hwang, Young Sun; Zhang, Xianglan; Park, Kwang Kyun; Chung, WonYoon.

In: Archives of Oral Biology, Vol. 58, No. 2, 01.01.2013, p. 218-225.

Research output: Contribution to journalArticle

TY - JOUR

T1 - An orthotopic and osteolytic model with a newly established oral squamous cell carcinoma cell line

AU - Hwang, Young Sun

AU - Zhang, Xianglan

AU - Park, Kwang Kyun

AU - Chung, WonYoon

PY - 2013/1/1

Y1 - 2013/1/1

N2 - Objective: Despite the availability of advanced clinical diagnostic systems, the overall 5-year survival rate for patients with oral squamous cell carcinoma (OSCC) has remained relatively poor over the past 2 decades. Appropriate animal models need to be developed according to the specific purpose of cancer research. However, most of the currently available oral cancer cell lines do not precisely reflect the characteristics of bone-invasive OSCC and cannot serve as suitable tools in the development of new therapeutic reagents against bone-invasive OSCC. Here, we assessed the orthotopic and osteolytic mouse model with newly established OSCC cell line. Design: We assessed the orthotopic and osteolytic mouse model using the newly established OSCC cells. In addition, the incidences of tumorigenesis and histopathological results were determined. Results: The newly established YD-39 cell line grows in a monolayer sheet and has highly invasive. The transplanted YD-39 cells developed stable tumours in the tongues and calvaria region of the nude mice. The tumours in nude mice grafted with YD-39 cells had a high incidence of transplantability in both mouse models tested and a similar morphology to their respective original tumour. Therefore, both animal models might be feasible animal models to assess the efficacy of anti-cancer drugs. Conclusions: This type of animal model approach might be has the added advantage of potentially accelerating the biological discovery process.

AB - Objective: Despite the availability of advanced clinical diagnostic systems, the overall 5-year survival rate for patients with oral squamous cell carcinoma (OSCC) has remained relatively poor over the past 2 decades. Appropriate animal models need to be developed according to the specific purpose of cancer research. However, most of the currently available oral cancer cell lines do not precisely reflect the characteristics of bone-invasive OSCC and cannot serve as suitable tools in the development of new therapeutic reagents against bone-invasive OSCC. Here, we assessed the orthotopic and osteolytic mouse model with newly established OSCC cell line. Design: We assessed the orthotopic and osteolytic mouse model using the newly established OSCC cells. In addition, the incidences of tumorigenesis and histopathological results were determined. Results: The newly established YD-39 cell line grows in a monolayer sheet and has highly invasive. The transplanted YD-39 cells developed stable tumours in the tongues and calvaria region of the nude mice. The tumours in nude mice grafted with YD-39 cells had a high incidence of transplantability in both mouse models tested and a similar morphology to their respective original tumour. Therefore, both animal models might be feasible animal models to assess the efficacy of anti-cancer drugs. Conclusions: This type of animal model approach might be has the added advantage of potentially accelerating the biological discovery process.

UR - http://www.scopus.com/inward/record.url?scp=84874106047&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84874106047&partnerID=8YFLogxK

U2 - 10.1016/j.archoralbio.2012.04.023

DO - 10.1016/j.archoralbio.2012.04.023

M3 - Article

C2 - 22621906

AN - SCOPUS:84874106047

VL - 58

SP - 218

EP - 225

JO - Archives of Oral Biology

JF - Archives of Oral Biology

SN - 0003-9969

IS - 2

ER -