Renal impairment (RI) is a relatively common complication of multiple myeloma, which increases in frequency as disease becomes more advanced and recovery of renal function becomes less likely as patients progress through lines of therapy. Clinical trials in the relapsed/refractory multiple myeloma (RRMM) setting have not uniformly included patients with RI or robustly reported their outcomes. Here, we review existing data among patients with RI and RRMM across drug classes (including immunomodulatory agents, proteasome inhibitors, monoclonal antibodies, antibody-drug conjugates, chimeric antigen receptor T-cell therapies, and exportin-1 inhibitor) to provide an improved understanding of available treatment options for this important population. We highlight data from pivotal clinical trials, including data relating to renal response (as defined by the International Myeloma Working Group) and discuss real-world experiences in patients with RI, where applicable. Despite substantial advances in RRMM treatment, the presence of RI remains associated with reduced overall survival. Consistent inclusion of patients with RI, and uniform reporting of their outcomes, should be encouraged in future prospective trials of treatments for RRMM.
|Journal||Therapeutic Advances in Hematology|
|Publication status||Published - 2022 Apr|
Bibliographical noteFunding Information:
Medical writing support was provided by Camile Semighini Grubor, PhD, and Lindsay Gasch, PharmD, of Elevate Medical Affairs, contracted by Sanofi Genzyme for publication support services. Authors were not reimbursed for authorship and had full control over content. The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This review article was funded by Sanofi.
The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This review article was funded by Sanofi.
© The Author(s), 2022.
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