Anaerobic bacteremia: Impact of inappropriate therapy on mortality

Jieun Kim, Yangsoon Lee, Yongjung Park, Myungsook Kim, JunYong Choi, DongEun Yong, Seokhoon Jeong, Kyungwon Lee

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background: Investigation on incidence and mortality of anaerobic bacteremia (AB) is clinically relevant in spite of its infrequent occurrence and not often explored, which report varies according to period and institutions. Therefore, it is necessary to analyze the incidence and risk factors related to mortality and assess clinical outcomes of AB in current aspect. Materials and Methods: Characteristics of AB patients and anaerobic bacteria from blood culture at a university hospital in 2012 were reviewed retrospectively. The correlation between risk factors and 28-day patient mortality was analyzed. Results: A total of 70 non-duplicated anaerobic bacteria were isolated from blood of 70 bacteremia patients in 2012. The history of cardiovascular disease as host's risk factor was statistically significant (P = 0.0344) in univariate and multivariate analysis. Although the inappropriate therapy was not statistically significant in univariate and multivariate analysis, the survival rate of bacteremia was significantly worse in patients who had inappropriate therapy compared with those underwent appropriate therapy (hazard ratio, 5.4; 95% confidence interval, 1.7-16.9; P = 0.004). The most frequently isolated organism was Bacteroides fragilis (32 isolates, 46%), followed by Bacteroides thetaiotaomicron (10, 14 %), and non-perfringens Clostridium (7, 10%). Conclusion: The incidence of AB in 2012 was 2.3% (number of AB patients per 100 positive blood culture patients) and the mortality rate in patients with clinically significant AB was 21.4%. In addition, AB was frequently noted in patients having malignancy and the survival rate of AB was significantly worse in patients who received inappropriate therapy compared with those underwent appropriate therapy.

Original languageEnglish
Pages (from-to)91-98
Number of pages8
JournalInfection and Chemotherapy
Volume48
Issue number2
DOIs
Publication statusPublished - 2016 Jan 1

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Bacteremia
Mortality
Therapeutics
Anaerobic Bacteria
Incidence
Multivariate Analysis
Survival Rate
Bacteroides fragilis
Clostridium
Cardiovascular Diseases
History
Confidence Intervals

All Science Journal Classification (ASJC) codes

  • Infectious Diseases
  • Pharmacology (medical)

Cite this

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title = "Anaerobic bacteremia: Impact of inappropriate therapy on mortality",
abstract = "Background: Investigation on incidence and mortality of anaerobic bacteremia (AB) is clinically relevant in spite of its infrequent occurrence and not often explored, which report varies according to period and institutions. Therefore, it is necessary to analyze the incidence and risk factors related to mortality and assess clinical outcomes of AB in current aspect. Materials and Methods: Characteristics of AB patients and anaerobic bacteria from blood culture at a university hospital in 2012 were reviewed retrospectively. The correlation between risk factors and 28-day patient mortality was analyzed. Results: A total of 70 non-duplicated anaerobic bacteria were isolated from blood of 70 bacteremia patients in 2012. The history of cardiovascular disease as host's risk factor was statistically significant (P = 0.0344) in univariate and multivariate analysis. Although the inappropriate therapy was not statistically significant in univariate and multivariate analysis, the survival rate of bacteremia was significantly worse in patients who had inappropriate therapy compared with those underwent appropriate therapy (hazard ratio, 5.4; 95{\%} confidence interval, 1.7-16.9; P = 0.004). The most frequently isolated organism was Bacteroides fragilis (32 isolates, 46{\%}), followed by Bacteroides thetaiotaomicron (10, 14 {\%}), and non-perfringens Clostridium (7, 10{\%}). Conclusion: The incidence of AB in 2012 was 2.3{\%} (number of AB patients per 100 positive blood culture patients) and the mortality rate in patients with clinically significant AB was 21.4{\%}. In addition, AB was frequently noted in patients having malignancy and the survival rate of AB was significantly worse in patients who received inappropriate therapy compared with those underwent appropriate therapy.",
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Anaerobic bacteremia : Impact of inappropriate therapy on mortality. / Kim, Jieun; Lee, Yangsoon; Park, Yongjung; Kim, Myungsook; Choi, JunYong; Yong, DongEun; Jeong, Seokhoon; Lee, Kyungwon.

In: Infection and Chemotherapy, Vol. 48, No. 2, 01.01.2016, p. 91-98.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Anaerobic bacteremia

T2 - Impact of inappropriate therapy on mortality

AU - Kim, Jieun

AU - Lee, Yangsoon

AU - Park, Yongjung

AU - Kim, Myungsook

AU - Choi, JunYong

AU - Yong, DongEun

AU - Jeong, Seokhoon

AU - Lee, Kyungwon

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Background: Investigation on incidence and mortality of anaerobic bacteremia (AB) is clinically relevant in spite of its infrequent occurrence and not often explored, which report varies according to period and institutions. Therefore, it is necessary to analyze the incidence and risk factors related to mortality and assess clinical outcomes of AB in current aspect. Materials and Methods: Characteristics of AB patients and anaerobic bacteria from blood culture at a university hospital in 2012 were reviewed retrospectively. The correlation between risk factors and 28-day patient mortality was analyzed. Results: A total of 70 non-duplicated anaerobic bacteria were isolated from blood of 70 bacteremia patients in 2012. The history of cardiovascular disease as host's risk factor was statistically significant (P = 0.0344) in univariate and multivariate analysis. Although the inappropriate therapy was not statistically significant in univariate and multivariate analysis, the survival rate of bacteremia was significantly worse in patients who had inappropriate therapy compared with those underwent appropriate therapy (hazard ratio, 5.4; 95% confidence interval, 1.7-16.9; P = 0.004). The most frequently isolated organism was Bacteroides fragilis (32 isolates, 46%), followed by Bacteroides thetaiotaomicron (10, 14 %), and non-perfringens Clostridium (7, 10%). Conclusion: The incidence of AB in 2012 was 2.3% (number of AB patients per 100 positive blood culture patients) and the mortality rate in patients with clinically significant AB was 21.4%. In addition, AB was frequently noted in patients having malignancy and the survival rate of AB was significantly worse in patients who received inappropriate therapy compared with those underwent appropriate therapy.

AB - Background: Investigation on incidence and mortality of anaerobic bacteremia (AB) is clinically relevant in spite of its infrequent occurrence and not often explored, which report varies according to period and institutions. Therefore, it is necessary to analyze the incidence and risk factors related to mortality and assess clinical outcomes of AB in current aspect. Materials and Methods: Characteristics of AB patients and anaerobic bacteria from blood culture at a university hospital in 2012 were reviewed retrospectively. The correlation between risk factors and 28-day patient mortality was analyzed. Results: A total of 70 non-duplicated anaerobic bacteria were isolated from blood of 70 bacteremia patients in 2012. The history of cardiovascular disease as host's risk factor was statistically significant (P = 0.0344) in univariate and multivariate analysis. Although the inappropriate therapy was not statistically significant in univariate and multivariate analysis, the survival rate of bacteremia was significantly worse in patients who had inappropriate therapy compared with those underwent appropriate therapy (hazard ratio, 5.4; 95% confidence interval, 1.7-16.9; P = 0.004). The most frequently isolated organism was Bacteroides fragilis (32 isolates, 46%), followed by Bacteroides thetaiotaomicron (10, 14 %), and non-perfringens Clostridium (7, 10%). Conclusion: The incidence of AB in 2012 was 2.3% (number of AB patients per 100 positive blood culture patients) and the mortality rate in patients with clinically significant AB was 21.4%. In addition, AB was frequently noted in patients having malignancy and the survival rate of AB was significantly worse in patients who received inappropriate therapy compared with those underwent appropriate therapy.

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DO - 10.3947/ic.2016.48.2.91

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VL - 48

SP - 91

EP - 98

JO - Infection and Chemotherapy

JF - Infection and Chemotherapy

SN - 2093-2340

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