Abstract
Purpose To assess the effect of preoperative topical nonsteroidal antiinflammatory drugs (NSAIDs) on postoperative pain after laser-assisted subepithelial keratectomy (LASEK) and to investigate their mechanism. Setting Severance Eye Hospital and Saeyan Eye Clinic, Seoul, South Korea. Design Prospective randomized clinical trial. Methods Participants in 2 related studies were assessed. Study 1 comprised patients scheduled for bilateral LASEK (Group 1) who were randomized to receive an NSAID in 1 eye and a placebo in the fellow eye 30, 20, and 10 minutes before LASEK. Postoperative pain, glare, tearing, and irritation were assessed using a visual analog scale. Study 2 comprised healthy subjects (Group 2) who were randomly divided into subgroups. The participants in these subgroups were randomized to receive ketorolac tromethamine 0.5% in 1 eye and placebo (ofloxacin 0.3%) in the fellow eye (Group 2A), proparacaine hydrochloride 0.5% in 1 eye and placebo in the fellow eye (Group 2B), or ketorolac tromethamine 0.5% in 1 eye and placebo in the fellow eye, followed 10 minutes later by 1 drop of proparacaine hydrochloride 0.5% in both eyes (Group 2C). In all 3 groups, corneal sensitivity was measured after 1, 2, and 6 hours. Results The mean postoperative pain score in the NSAID-pretreated eye was statistically significantly lower than in the placebo-pretreated eye 6, 12, and 24 hours postoperatively (P <.05). The mean corneal sensitivity was statistically significantly lower in the NSAID-treated eye than in the placebo-treated eye at 1 and 2 hours in Groups 2A and 2C (P <.05). Conclusion Preoperative administration of topical NSAIDs before LASEK effectively reduces postoperative pain. Financial Disclosure No author has a financial or proprietary interest in any material or method mentioned.
| Original language | English |
|---|---|
| Pages (from-to) | 749-755 |
| Number of pages | 7 |
| Journal | Journal of Cataract and Refractive Surgery |
| Volume | 41 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2015 Jan 1 |
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All Science Journal Classification (ASJC) codes
- Surgery
- Ophthalmology
- Sensory Systems
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Analgesic effect of preoperative topical nonsteroidal antiinflammatory drugs on postoperative pain after laser-assisted subepithelial keratectomy. / Kim, Se Kyung; Hong, Jin Pyo; Nam, Sang Min; Stulting, Robert Doyle; Seo, KyoungYul.
In: Journal of Cataract and Refractive Surgery, Vol. 41, No. 4, 01.01.2015, p. 749-755.Research output: Contribution to journal › Article
TY - JOUR
T1 - Analgesic effect of preoperative topical nonsteroidal antiinflammatory drugs on postoperative pain after laser-assisted subepithelial keratectomy
AU - Kim, Se Kyung
AU - Hong, Jin Pyo
AU - Nam, Sang Min
AU - Stulting, Robert Doyle
AU - Seo, KyoungYul
PY - 2015/1/1
Y1 - 2015/1/1
N2 - Purpose To assess the effect of preoperative topical nonsteroidal antiinflammatory drugs (NSAIDs) on postoperative pain after laser-assisted subepithelial keratectomy (LASEK) and to investigate their mechanism. Setting Severance Eye Hospital and Saeyan Eye Clinic, Seoul, South Korea. Design Prospective randomized clinical trial. Methods Participants in 2 related studies were assessed. Study 1 comprised patients scheduled for bilateral LASEK (Group 1) who were randomized to receive an NSAID in 1 eye and a placebo in the fellow eye 30, 20, and 10 minutes before LASEK. Postoperative pain, glare, tearing, and irritation were assessed using a visual analog scale. Study 2 comprised healthy subjects (Group 2) who were randomly divided into subgroups. The participants in these subgroups were randomized to receive ketorolac tromethamine 0.5% in 1 eye and placebo (ofloxacin 0.3%) in the fellow eye (Group 2A), proparacaine hydrochloride 0.5% in 1 eye and placebo in the fellow eye (Group 2B), or ketorolac tromethamine 0.5% in 1 eye and placebo in the fellow eye, followed 10 minutes later by 1 drop of proparacaine hydrochloride 0.5% in both eyes (Group 2C). In all 3 groups, corneal sensitivity was measured after 1, 2, and 6 hours. Results The mean postoperative pain score in the NSAID-pretreated eye was statistically significantly lower than in the placebo-pretreated eye 6, 12, and 24 hours postoperatively (P <.05). The mean corneal sensitivity was statistically significantly lower in the NSAID-treated eye than in the placebo-treated eye at 1 and 2 hours in Groups 2A and 2C (P <.05). Conclusion Preoperative administration of topical NSAIDs before LASEK effectively reduces postoperative pain. Financial Disclosure No author has a financial or proprietary interest in any material or method mentioned.
AB - Purpose To assess the effect of preoperative topical nonsteroidal antiinflammatory drugs (NSAIDs) on postoperative pain after laser-assisted subepithelial keratectomy (LASEK) and to investigate their mechanism. Setting Severance Eye Hospital and Saeyan Eye Clinic, Seoul, South Korea. Design Prospective randomized clinical trial. Methods Participants in 2 related studies were assessed. Study 1 comprised patients scheduled for bilateral LASEK (Group 1) who were randomized to receive an NSAID in 1 eye and a placebo in the fellow eye 30, 20, and 10 minutes before LASEK. Postoperative pain, glare, tearing, and irritation were assessed using a visual analog scale. Study 2 comprised healthy subjects (Group 2) who were randomly divided into subgroups. The participants in these subgroups were randomized to receive ketorolac tromethamine 0.5% in 1 eye and placebo (ofloxacin 0.3%) in the fellow eye (Group 2A), proparacaine hydrochloride 0.5% in 1 eye and placebo in the fellow eye (Group 2B), or ketorolac tromethamine 0.5% in 1 eye and placebo in the fellow eye, followed 10 minutes later by 1 drop of proparacaine hydrochloride 0.5% in both eyes (Group 2C). In all 3 groups, corneal sensitivity was measured after 1, 2, and 6 hours. Results The mean postoperative pain score in the NSAID-pretreated eye was statistically significantly lower than in the placebo-pretreated eye 6, 12, and 24 hours postoperatively (P <.05). The mean corneal sensitivity was statistically significantly lower in the NSAID-treated eye than in the placebo-treated eye at 1 and 2 hours in Groups 2A and 2C (P <.05). Conclusion Preoperative administration of topical NSAIDs before LASEK effectively reduces postoperative pain. Financial Disclosure No author has a financial or proprietary interest in any material or method mentioned.
UR - http://www.scopus.com/inward/record.url?scp=84926350186&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84926350186&partnerID=8YFLogxK
U2 - 10.1016/j.jcrs.2014.06.041
DO - 10.1016/j.jcrs.2014.06.041
M3 - Article
C2 - 25840299
AN - SCOPUS:84926350186
VL - 41
SP - 749
EP - 755
JO - Journal of Cataract and Refractive Surgery
JF - Journal of Cataract and Refractive Surgery
SN - 0886-3350
IS - 4
ER -